1999
DOI: 10.1046/j.1365-2826.1999.00350.x
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Long‐Lasting Deficient Dexamethasone Suppression of Hypothalamic‐Pituitary‐Adrenocortical Activation Following Peripheral CRF Challenge in Socially Defeated Rats

Abstract: The present study focuses on the long-term changes in the regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis following two short-lasting episodes of intensive stress in the rat stress model of social defeat and the possible similarities with HPA functioning in human affective disorders. Male Wistar rats experienced social defeats on 2 consecutive days by an aggressive male conspecific. The long-term effect of these defeats on resting and ovine corticotropin-releasing factor (oCRF; intravenous (… Show more

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Cited by 124 publications
(70 citation statements)
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“…Preclinical studies have shown that the development of receptor alterations after intense social stress is time-dependent. 50,51 In a clinical design, significant correlations between the time passed since the traumatic event and in vivo DEX sensitivity have been reported. 52 In line with these observations, it is important to highlight that our results are strengthened by the inclusion of a homogeneous population in type of trauma, moment of trauma in lifespan and the time passed since the traumatic event.…”
Section: Discussionmentioning
confidence: 99%
“…Preclinical studies have shown that the development of receptor alterations after intense social stress is time-dependent. 50,51 In a clinical design, significant correlations between the time passed since the traumatic event and in vivo DEX sensitivity have been reported. 52 In line with these observations, it is important to highlight that our results are strengthened by the inclusion of a homogeneous population in type of trauma, moment of trauma in lifespan and the time passed since the traumatic event.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, stress induced by social defeat has been found to prompt long-lasting changes in the regulation of the HPA system in rats, in that the ACTH response to CRH after DEX administration was significantly greater in defeated rats than in controls (Buwalda et al 1999). These changes were reflected in temporal dynamic alterations in hippocampal, hypothalamic and pituitary GR and MR binding.…”
Section: Involvement Of Glucocorticoid and Mineralocorticoid Receptorsmentioning
confidence: 99%
“…In the resident/ intruder test, the intruder is repeatedly subjected to attacks and threats from the dominant resident, and these attacks often persist even after the intruder signals defeat by displaying behavioral submission, similar to victims of bullying who are harassed and assaulted even though they do their utmost to avoid provoking the bully (Bjorkqvist, 2001;Vidal et al, 2007;Watt et al, 2009). The social defeat paradigm has been used successfully in adult laboratory rodents to elucidate some of the relevant neurobiological, physiological and behavioral changes caused by acute or chronic social defeat experience (Tornatzky and Miczek, 1993;Meerlo et al, 1996;Buwalda et al, 1999). In adult males, these effects have been demonstrated to persist long after the original defeat experience when the experimental intruder animals are singly housed following the defeat (Meerlo et al, 1996;Buwalda et al, 1999).…”
Section: Introductionmentioning
confidence: 99%
“…The social defeat paradigm has been used successfully in adult laboratory rodents to elucidate some of the relevant neurobiological, physiological and behavioral changes caused by acute or chronic social defeat experience (Tornatzky and Miczek, 1993;Meerlo et al, 1996;Buwalda et al, 1999). In adult males, these effects have been demonstrated to persist long after the original defeat experience when the experimental intruder animals are singly housed following the defeat (Meerlo et al, 1996;Buwalda et al, 1999). As for the beneficial aspect of the social environment such as social support during stress, adult laboratory rodents have been shown to respond positively to the presence of a non-hostile companion much like humans respond to the presence and support from a good friend during hardship (Ruis et al, 1999;Wilson, 2001;de Jong et al, 2005;Nakayasu and Ishii, 2008;Hennessy et al, 2009;Cherng et al, 2010;Macone et al, 2011).…”
Section: Introductionmentioning
confidence: 99%