Long-lasting delayed hyperalgesia after subchronic swim stress

Quintero, Luis; Moreno, M. P. N.; Avila, Carla; Arcaya, José Luis; Maixner, William; Suárez-Roca, Heberto

doi:10.1016/s0091-3057(00)00374-9

Cited by 179 publications

(163 citation statements)

References 22 publications

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“…Therefore, this is not a very satisfactory method of animal classifi cation, as it is based on a short lasting reaction and not on an enduring feature. The infl uence of trait anxiety on pain processing could be explained by: 1) possible differences on opioidergic and serotonergic activities between animals with high and low anxiety levels (Quintero et al, 2000;Torres et al, 2003;Gameiro et al, 2006); 2) possible differences in the levels of prostaglandins released during the infl ammatory response between animals with high and low anxiety levels (Morimoto et al, 1991); 3) possible glucocorticoid-resistence in animals with high anxiety levels (Miller et al, 2002); 4) possible differences on NK1 receptor expression between animals with high and low levels of anxiety (Ramos et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between anxiety and pain is a common experience in both preclinical (Quintero et al, 2000;Torres et al, 2001;Gameiro et al, 2006;Wilson et al, 2007) and clinical studies (Brown, 1990;Grachev et al, 2001;Dersh et al, 2002;McWilliams et al, 2003;Bonjardim et al, 2005). Preclinical investigations have confirmed the enhancing effect of anxiety on nociception for different components and measures, including nociception intensity (Al Absi and Rokke, 1991), nociception threshold (Rhudy and Meagher, 2000), and nociception discrimination (Schumacher and Velden, 1984).…”

Section: Introductionmentioning

confidence: 99%

“…So far, the general approach of preclinical studies to assess the relationship between anxiety and nociception has been to expose an animal to a stressor and examine the impact of this stressor on a nociception measure, or to evaluate alterations in anxiety processing following exposure to nociceptive stimuli (Takahashi and Kaneto 1999;Quintero et al, 2000;Torres et al, 2001;Gameiro et al, 2006;Boccalon et al, 2006). To the best of our knowledge, until now, only two studies have been aimed at evaluating the infl uence of baseline levels of anxiety (high and low) on pain processing (Ramos et al, 2002;Wilson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Trait anxiety affects the orofacial nociceptive response in rats

et al. 2011

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The aims of the present study were to assess the infl uence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Fortyfour rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profi les. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait anxiety when presenting values below the 1st quartile, or above the 3rd quartile, respectively. A week later, formalin-1.5% was injected into the upper lip of each animal. The behavioural nociceptive response, characterized by increased orofacial rubbing (OR), was quantifi ed for 30 minutes, as follows: Total time OR (0-30 minutes: total pain), 1st phase OR (0-6 minutes: neurogenic pain), and 2nd phase OR (12-30 minutes: infl ammatory pain). Immediately after this test, but still under the effect of formalin, the rats were submitted to the Elevated Plus-maze test (EPM). The results showed that the high trait anxiety individuals presented higher frequency of OR than the low trait anxiety ones, except during the neurogenic pain period. However, no correlation was found between OR frequency and levels of state anxiety presented on the EPM. In conclusion, the animals presenting higher anxiety profi les were the most susceptible to orofacial pain, nevertheless, orofacial pain did not infl uence state anxiety.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trait anxiety affects the orofacial nociceptive response in rats

et al. 2011

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“…The overall effect of these drugs is to enhance sleep and coping; reduce anxiety, and catastrophizing, all of which impact upon the neuromatix and ameliorate the pain experience. [5,13,42,43,48] In addition, TCAs are also thought to have a beneficial neuro-hormonal impact, and potentiate endogenous opioids. [42] Opioids and Tramadol The use of opioids for chronic pain is open to some controversy.…”

Section: Therapymentioning

confidence: 99%

Central Sensitization: Clinical Implications for Chronic Head and Neck Pain

Roberts¹

2012

CMD

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Chronic clinical pain associated with CS, is a potentially progressive, devastating, multimodal disease with a significant worldwide economic and social burden. Effective intervention is dependent upon recognizing the fundamental differences in acute and chronic pain, the effects on and by the neuromatrix upon the biopsychosocial health of the individual patient, and integrating that knowledge into a comprehensive multidisciplinary therapeutic plan.

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“…In the inflammation initial phases, central and peripheral opioid receptors are involved in the antinociceptive effects, and receptors located in peripheral nervous terminals may be activated by exogenous and endogenous opioids, expressed in immune cells to produce significant antinoniception 5,6 . Although physical exercise is frequently recommended for patients with chronic pain 7 and exercises in water be commonly prescribed for those who should avoid activities of weight discharge, the literature is still controverse 8,9 . Thus, the aim of this research was to evaluate whether resistance exercise produces alterations on the nociceptive episodes and if it suffers interferences by the application of an opioid inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Uso do exercício resistido antagonizado por naloxone como fator de analgesia em sinovite aguda de joelho de ratos Wistar

Bertolini

Rosa

Silva

et al. 2012

Rev Bras Med Esporte

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Analgesia arising from exercising can occur via release of endogenous opioids in the central nervous system and periphery. However, the literature remains controversial about exercise ways and actions in pain. Thus, the aim of this study was to evaluate whether resistance exercise produces changes on the nociception and suffers interference by applying an opioid inhibitor. 18 rats divided into three groups were used: G1 -hyperalgesia on right knee and untreated; G2 -hyperalgesia and treated with jump sin water; G3-hyperalgesia with previous injection of naloxone and subsequent jumps. To produce hyperalgesia,100µl of 5% formalin was injected in the tibio femoral joint space. Pain was assessed using a digital von Frey filament on the right medial tibiofemoral joint. The evaluation periods were: pre-injury (EV1) after 15 minutes (EV2) and 30 minutes (EV3) and one hour (EV4). The applied exercise was jumpingin water and it occurred after EV2. The animal performed 4 sets of 5 jumps, with an interval of 3 minutes and overload of 50% of body weight. In G1, nociceptive increase was observed, with significant decrease and return to initial baseline values in AV4; G2 showed threshold restoration after exercise and return to baseline; G3 reduced thresholds, without restoration or significant increase in them. We concluded that there was analgesia withuse of exercise and that it was altered by blocking beta-endorphin.

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Long-lasting delayed hyperalgesia after subchronic swim stress

Cited by 179 publications

References 22 publications

Trait anxiety affects the orofacial nociceptive response in rats

Trait anxiety affects the orofacial nociceptive response in rats

Central Sensitization: Clinical Implications for Chronic Head and Neck Pain

Uso do exercício resistido antagonizado por naloxone como fator de analgesia em sinovite aguda de joelho de ratos Wistar

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