Long lasting effects of chronic heavy cannabis abuse

Nestoros, Joannis N.; Vakonaki, Elena; Tzatzarakis, Manolis; Alegakis, Athanasios; Skondras, Markos; Tsatsakis, Aristidis

doi:10.1111/ajad.12529

Cited by 22 publications

(14 citation statements)

References 41 publications

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“…If this hypothesis explains our results, it would be plausible that acute cannabis use in CCUs may indeed hide an underlying impairment in cerebellar-dependent motor adaptation. Although our results show very subtle alterations compared to ataxic patients, these might be the first signs of a future clinically significant impairment that will only manifest with continuous heavy use [41]. Future longitudinal studies will clarify whether these early cerebellar alterations prelude long-term clinical symptoms.…”

Section: Discussionmentioning

confidence: 73%

Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task

Herreros

Miquel

Blithikioti

et al. 2019

JCM

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Background—The cerebellum has been recently suggested as an important player in the addiction brain circuit. Cannabis is one of the most used drugs worldwide, and its long-term effects on the central nervous system are not fully understood. No valid clinical evaluations of cannabis impact on the brain are available today. The cerebellum is expected to be one of the brain structures that are highly affected by prolonged exposure to cannabis, due to its high density in endocannabinoid receptors. We aim to use a motor adaptation paradigm to indirectly assess cerebellar function in chronic cannabis users (CCUs). Methods—We used a visuomotor rotation (VMR) task that probes a putatively-cerebellar implicit motor adaptation process together with the learning and execution of an explicit aiming rule. We conducted a case-control study, recruiting 18 CCUs and 18 age-matched healthy controls. Our main measure was the angular aiming error. Results—Our results show that CCUs have impaired implicit motor adaptation, as they showed a smaller rate of adaptation compared with healthy controls (drift rate: 19.3 +/− 6.8° vs. 27.4 +/− 11.6°; t(26) = −2.1, p = 0.048, Cohen’s d = −0.8, 95% CI = (−1.7, −0.15)). Conclusions—We suggest that a visuomotor rotation task might be the first step towards developing a useful tool for the detection of alterations in implicit learning among cannabis users.

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Section: Discussionmentioning

confidence: 73%

Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task

Herreros

Miquel

Blithikioti

et al. 2019

JCM

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“…While less common, acute psychosis, including hallucinations and delusions, can occur when taken in high doses (Nestoros et al., 2017). More typically, the user may feel relaxed or calm and in what is described as a “dreamlike state,” disconnected from reality and may show difficulty having a coherent conversation.…”

Section: Cannabis and Psychological Functioningmentioning

confidence: 99%

A perspective review of cannabis use and sexual offenses

Erickson¹,

Vorwerk²

2022

Behavioral Sci & The Law

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Substance abuse is an established risk factor for crime and violence, including sexual violence. Nevertheless, the link between cannabis use and sexual offenses remains poorly understood. Cannabis use has a broad effect on sexual functioning and can have both acute and lasting adverse effects on psychological functioning, which in turn can elevate the risk of sexual offending behavior. Yet there is a scarcity of studies that have examined the link between cannabis use and sexual offending. To help fill the gap, this perspective review investigates the link between substance use and crime with a particular emphasis on cannabis use and its effects on sexual and psychological functioning. It then explores how these mechanisms may contribute to sexual offenses and recidivism, with a final discussion on how cannabis use should be conceptualized as a risk factor for sexual violence.

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“…A nivel cerebral está correlacionado con modificaciones anatómicas, como adelgazamiento de la corteza o daños sobre el hipocampo 7,8 , lo que se podría asociar a problemas de memoria e impulsividad 9 . Como síntomas neurológicos asociados al consumo los que más se destacan son: alucinaciones, principalmente auditivas, menor calidad del sueño con adormecimiento diurno, delirios, alteración en funciones visual-motoras y percepción y memoria visual de evocación inmediata 10,11 .…”

Section: Consecuencias Negativas Del Consumo De Cannabisunclassified

Cannabis medicinal en Argentina: perspectiva desde la salud pública

Agnese

López

Vicenti

et al. 2019

Evid actual pract ambul

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Esta revisión analiza la situación actual de la utilización del como herramienta terapéutica dentro del ámbito de la salud en Argentina, haciendo referencia a los distintos actores involucrados y dilemas futuros que pueden presentarse. Paracomprender en su totalidad el marco social, cultural e histórico, se desarrollan distintos aspectos, como la descripción química y biológica del , evolución del consumo a través de la historia, las repercusiones del consumo y las distintas aplicaciones que tiene en el campo de la medicina. También se describen las diferentes realidades que hay en el mundo, así como las legislaciones de otros países y la comparación de estas con la que tenemos en nuestro país. Finalmente se mencionan los desafíos pendientes y sus posibles abordajes.

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Long lasting effects of chronic heavy cannabis abuse

Cited by 22 publications

References 41 publications

Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task

Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task

A perspective review of cannabis use and sexual offenses

Cannabis medicinal en Argentina: perspectiva desde la salud pública

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