Long-Lasting, Patient-Controlled, Procedure-Free Contraception: A Review of Annovera with a Pharmacist Perspective

Abstract

Annovera (segesterone acetate and ethinyl estradiol vaginal system) is a US Food and Drug Administration FDA-approved long-lasting, reversible contraceptive that is fully administered by the user and does not require a procedure for insertion or removal. The vaginal system is in the shape of a ring and contains low doses of a novel progestin, egesterone acetate, and ethinyl estradiol. It is made of silicone and is fully pliable and flexible. The vaginal system is reusable for 13 cycles, using a 21 days in/7 days out regimen, providing women with the ability to control their fertility. Particularly now during the COVID-19 pandemic when access to contraception has been further reduced, patients may benefit from a method that is both long-lasting and patient-controlled.

Update on current contraceptive options: A case-based discussion of efficacy, eligibility, and use

“…16 No backup contraception is needed if the intravaginal ring is reinserted within 2 hours of expulsion. 17 This may not be an appropriate method for those with diffi culty or pain using the vaginal ring, such as those with arthritis of the hands, pelvic fl oor dysfunction, vaginismus, preference to avoid intravaginal placement, or other limitations for correct use.…”

Preparation of Solid Dispersion of Polygonum Cuspidatum Extract by Hot Melt Extrusion to Enhance Oral Bioavailability of Resveratrol

“…Continuous extrusion processes are controlled by the hot melt extruder panel, and the extrudate could be pelletized, milled, mixed and 3D printed to dosage forms such as tablets, film, granules, capsules, and so on, which promotes the scalability of this technology. Several HME commercial products approved by the Food and Drug Administration (FDA), currently available in the market with different release targets, prove the potential and success of this technology [ 24 , 25 , 26 , 27 ].…”