There is a large number of grid-based climate datasets available which differ in terms of their data source, estimation procedures, and spatial and temporal resolutions. This study evaluates the performance of diverse meteorological datasets in terms of representing spatio-temporal climate variabilities based on a national-scale domain over South Korea. Eleven precipitation products, including six satellite-based data (CMORPH, MSWEP, MERRA, PERSIANN, TRMM, and TRMM-RT) and five reanalysis-based data (ERA5, JRA-55, CPC-U, NCEP-DOE, and K-Hidra) and four temperature products (MERRA, ERA5, CPC-U, and NCEP-DOE) are investigated. In addition, the hydrological performance of forty-four input combinations of climate datasets are explored by using the Variable Infiltration Capacity (VIC) macroscale model. For this analysis, the VIC model is independently calibrated for each combination of input and the response to each combination is then evaluated with in situ streamflow data. Our results show that the gridded datasets perform differently particularly in representing precipitation variability. When a diverse combination of the datasets are used to represent spatio-temporal variability of streamflow through the hydrological model, K-Hidra and CPC-U performed best for precipitation and temperature, followed by the MERRA and ERA5 datasets, respectively. Lastly, we obtain only marginal improvement in the hydrological performance when utilizing multiple climate datasets after comparing it to a single hydrological simulation with the best performing climate dataset. Overall, our results indicate that the hydrological performance may vary considerably based on the selection of climate datasets, emphasizing the importance of regional evaluation studies for meteorological datasets.