Long-live euthymic BALB/c-nu mice. I. Survival study suggests body weight as a life span predictor

Piantanelli, L.; Alimazighi, Zaïa; Rossolini, G.; Piantanelli, Anna; Basso, Andrea; Anisimov, Vladimir N.

doi:10.1016/s0047-6374(00)00256-6

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…This finding was unexpected given the body of literature demonstrating cognitive, hearing and lifespan benefits of caloric restriction (Sohal and Weindruch, 1996, Someya, et al, 2007). Under normal conditions, body weight increases with age in mice, but then drifts downward at the oldest ages (Goodrick, et al, 1990, Miller, et al, 2002, Piantanelli, et al, 2001, Samorajski, et al, 1985). Although lower body weights at mid-life may predict better late-life health outcomes in rodents, this relationship weakens for body weights measured once animals are senescent (Miller, et al, 2002, Piantanelli, et al, 2001) and shows variability based on strain and specific health outcomes measured (Anisimov, et al, 2004).…”

Section: 0 Discussionmentioning

confidence: 99%

“…Under normal conditions, body weight increases with age in mice, but then drifts downward at the oldest ages (Goodrick, et al, 1990, Miller, et al, 2002, Piantanelli, et al, 2001, Samorajski, et al, 1985). Although lower body weights at mid-life may predict better late-life health outcomes in rodents, this relationship weakens for body weights measured once animals are senescent (Miller, et al, 2002, Piantanelli, et al, 2001) and shows variability based on strain and specific health outcomes measured (Anisimov, et al, 2004). Therefore, one potential explanation of these data is that older, lighter animals may be generally less healthy, manifesting in lowered body weight, worsened hearing, and higher hippocampal redox ratios.…”

Section: 0 Discussionmentioning

confidence: 99%

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The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging

Stebbings

Choi

Ravindra

et al. 2016

Neurobiology of Aging

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The relationships between oxidative stress in the hippocampus and other aging-related changes such as hearing loss, cortical thinning or changes in body weight are not yet known. We measured the redox ratio in a number of neural structures in brain slices taken from young and aged mice. Hearing thresholds, body weight and cortical thickness were also measured. We found striking aging-related increases in the redox ratio that were isolated to the stratum pyramidale, while such changes were not observed in thalamus or cortex. These changes were driven primarily by changes in FAD, not NADH. Multiple regression analysis suggested that neither hearing threshold nor cortical thickness independently contributed to this change in hippocampal redox ratio. However, body weight did independently contribute to predicted changes in hippocampal redox ratio. These data suggest that aging-related changes in hippocampal redox ratio are not a general reflection of overall brain oxidative state, but are highly localized, while still being related to at least one marker of late aging, weight loss at the end of life.

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Section: 0 Discussionmentioning

confidence: 99%

Section: 0 Discussionmentioning

confidence: 99%

The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging

Stebbings

Choi

Ravindra

et al. 2016

Neurobiology of Aging

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“…[8][9][10] Long-lived mice have less cancer. 11,12 Centenarians, who age slowly, are endowed with a peculiar resistance to cancer. 13 Also, cancer and other age-related diseases are associated.…”

Section: Why Common Cancer Is An Age-related Disease?mentioning

confidence: 99%

Prevention of cancer by inhibiting aging

Blagosklonny¹

2008

Cancer Biology & Therapy

105

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Aging is associated with cancer, in particular with breast, prostate, colon, lung, stomach, bladder and skin cancer. This article discusses how aging predisposes one to cancer. In principle, inhibition of aging should delay cancer. But is it possible to slow aging? As recently proposed, the nutrient-sensing TOR (target of rapamycin) pathway is involved in cellular and organismal aging. In rodents, certain conditions that interfere with the TOR pathway slow aging and prevent cancer. Retrospective analysis of clinical data reveals that inhibitors of TOR prevent cancer in humans. This article envisions a potential clinical use of TOR inhibitors in order to slow aging and delay cancer.

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“…Consistent with a systemic link between aging and cancer, calorie restriction is known to both slow aging and delay cancer in rodents. [15][16][17][18] Likewise, long-lived mice have a lower incidence of cancer compared to shorter-lived mice, 19,20 and centenarians, people who age slowly, are generally remarkably cancer-free. 21 Indeed, many interventions that slow aging also delay cancer, and many interventions that accelerate aging (e.g., many progeroid syndromes) also increase the cancer incidence.…”

Section: Cancer Is An Age-related Diseasementioning

confidence: 99%

Cancer and aging: More puzzles, more promises?

Blagosklonny¹,

Campisi²

2008

Cell Cycle

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In this issue of Cell Cycle, a new paper shows that metformin, an oral antidiabetic drug that activates AMP-activated protein kinase, prolongs both mean and maximal life span and prevents reproductive aging of female mice. Unexpectedly, metformin did not decrease the incidence of cancer in this mice strain. Here, we discuss the relationship between aging and cancer, the mechanism of metformin action, and the prospects of using this compound for life span extension in humans.

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Long-live euthymic BALB/c-nu mice. I. Survival study suggests body weight as a life span predictor

Cited by 15 publications

References 25 publications

The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging

The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging

Prevention of cancer by inhibiting aging

Cancer and aging: More puzzles, more promises?

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