Long-lived and short-lived reactive species produced by a cold atmospheric pressure plasma jet for the inactivation of Pseudomonas aeruginosa and Staphylococcus aureus

Kondeti, V. S. Santosh K.; Phan, Chi Q.; Wende, Kristian; Jablonowski, Helena; Gangal, Urvashi; Granick, Jennifer L.; Hunter, Ryan C.; Bruggeman, Peter

doi:10.1016/j.freeradbiomed.2018.05.083

Cited by 152 publications

(110 citation statements)

References 64 publications

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“…Due to the difficulties in selective induction of atomic oxygen into liquids, its reactions in aqueous solutions are largely unknown. One of such reactions is the oxidation of Cl − , which was recently proposed by Kondeti et al [39].…”

Section: Studying the Reaction Between Atomic O And CL − In The Liquimentioning

confidence: 99%

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Applications of the COST Plasma Jet: More than a Reference Standard

Gorbanev

Golda

Gathen

et al. 2019

Plasma

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The rapid advances in the field of cold plasma research led to the development of many plasma jets for various purposes. The COST plasma jet was created to set a comparison standard between different groups in Europe and the world. Its physical and chemical properties are well studied, and diagnostics procedures are developed and benchmarked using this jet. In recent years, it has been used for various research purposes. Here, we present a brief overview of the reported applications of the COST plasma jet. Additionally, we discuss the chemistry of the plasma-liquid systems with this plasma jet, and the properties that make it an indispensable system for plasma research.

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Section: Studying the Reaction Between Atomic O And CL − In The Liquimentioning

confidence: 99%

“…Cold plasma medicine is one of the most extensive fields of CAP research. It comprises many applications, from cosmetic dentistry and biomedical materials production [1,9,29] to bacterial deactivation [39,44] and anti-cancer therapy [38,45].…”

Section: Biomedical Researchmentioning

confidence: 99%

Applications of the COST Plasma Jet: More than a Reference Standard

Gorbanev

Golda

Gathen

et al. 2019

Plasma

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“…A more in‐depth look demonstrates the capacities of CAP with respect to promoting wound healing, accelerating blood coagulation, killing pathogenic microorganisms, and even killing tumour cells selectively in vitro with little damage to normal cells . Current literature shows that CAP has an effect on common resistant pathogenic microorganisms on human skin, such as Staphylococcus aureus and fungi . CAP has demonstrated an excellent eradicating effect on these pathogenic microorganisms, but with no impact on normal tissue.…”

Section: Introductionmentioning

confidence: 99%

Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Gao

Wang

Xia

et al. 2019

International Wound Journal

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Superficial skin erosion wounds are very common in the clinic, and conventional treatments are not always effective; thus, effective and novel therapy is needed. Cold atmospheric plasma (CAP) has been recognised as a promising approach to wound healing. The purpose of this study is to show the potential clinical application of CAP for the healing of different kinds of superficial skin wounds. Seven patients with different kinds of superficial skin wounds (two patients with pyoderma gangrenosum, two patients with trauma would, one patient with giant genital wart, one patient with diabetic foot, and one patient with chronic eczema) were recruited to this study. All patients accepted and received CAP treatment every other day till the wound healed. The expected results were complete wound healing after CAP treatment. All patients achieved complete wound healing after several rounds (range from two to eight) of CAP treatment, and there was no side effect observed. CAP may provide a new and effective choice to solve the problem of the healing of superficial wounds that are not only caused by trauma but also because of eczema. CAP has certain value in the treatment of superficial skin diseases in the future.

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“…They reported on the synergy of H 2 O 2 and NO 2 − on killing cancer cells with PAM in which the antitumor effect is not observed when H 2 O 2 and NO 2 − are separately applied . In an argon plasma jet in contact with liquid, Kondeti et al showed that short‐lived species such as OH and superoxide (O 2 − ) are involved in the inactivation of bacteria in saline solution.…”

Section: Introductionmentioning

confidence: 99%

Helium plasma jet interactions with water in well plates

Mohades

Lietz

Kruszelnicki

et al. 2019

Plasma Processes & Polymers

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Plasma activation of liquids or cell cultures is a method for investigating the consequences of plasma produced reactive oxygen and nitrogen species (RONS) on living systems. The reproducible transfer of RONS, ions, electrons, and photons to the liquid is critical for determining reaction mechanisms and biological outcomes, and depends strongly on system parameters. A common in vitro method of plasma treatment of cells is a plasma jet directed into a well plate filled (or partially filled) with a liquid cell growth media. This method of treatment intrinsically has several environmental and geometrical factors that could lead to variability in the activation of the media. Uncontrolled or unreported geometrical and environmental factors that affect this transfer can, therefore, influence the reproducibility of measurements. In this paper, results from a numerical modeling investigation of a pulsed helium plasma jet interacting with water in a well plate are discussed while varying the height of the well‐plate rim. The height of the rim changes gas flow patterns, the ratio of He‐to‐air, and the water vapor content in the gas layer above the liquid. With a low rim, gas flowing from the jet stagnates on‐axis and flows radially outward with few vortices that recirculate reactants. With high rims, the gas flow is dominated by vortices and recirculation. With a low rim, the ionization wave (IW) from the jet strikes the liquid and proceeds as a surface IW across the water. With higher rims, the densities of helium and water vapor are higher above the liquid, which results in a volumetric propagation of the IW, initially producing higher densities of H2, HO2, OH, and H2O2. The end result is that for otherwise identical conditions, the densities of solvated H2O2aq and select reactive nitrogen species increase with rim height due to the vortices that recirculate reactants.

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Long-lived and short-lived reactive species produced by a cold atmospheric pressure plasma jet for the inactivation of Pseudomonas aeruginosa and Staphylococcus aureus

Cited by 152 publications

References 64 publications

Applications of the COST Plasma Jet: More than a Reference Standard

Applications of the COST Plasma Jet: More than a Reference Standard

Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Helium plasma jet interactions with water in well plates

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