Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression

Cai, Sheng; Zhou, Yi; Pan, Ying; Liu, Pengpeng; Yu, Kai-Jie; Chen, Shuzheng

doi:10.1007/s13577-021-00554-8

Cited by 10 publications

(7 citation statements)

References 36 publications

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“…Bai et al [ 11 ] observed that A1BG-AS1 level was down-regulated in hepatocellular carcinoma, and that its enforced expression inhibited tumor cell proliferation, migration, and invasion in vitro, whereas the knockdown promoted the malignant behavior of cells. Cai et al [ 31 ] found that A1BG-AS1 was high-expressed in breast cancer, and A1BG-AS1 removal accelerated cancer cell apoptosis and inhibited metastasis. Han et al .…”

Section: Discussionmentioning

confidence: 99%

Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification

Yang,

Luo,

Zhang

et al. 2024

Cell Div

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Background Exosome-derived long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) modifications of lncRNAs have been shown crucial functions in prostate cancer (PCa). Herein, we aim to investigate the detailed mechanism of exosome-derived lncRNA A1BG-AS1 in PCa process. Methods PCa cell exosomes were extracted, exosomal marker proteins (CD63, CD9) were detected utilizing western blotting, and exosomes with overexpressing A1BG-AS1 were co-cultured with targeted PCa cells. qRT-PCR was used to detect A1BG-AS1 expression and m6A methyltransferase ZC3H13 in PCa. Transwell, colony formation and CCK-8 assays were utilized to assess the invasion, migration, and proliferation ability of PCa cells. Then, we performed actinomycin D and MeRIP assays to analyze the regulatory effect of ZC3H13 on A1BG-AS1 mRNA stability and m6A modification level. Results We observed that A1BG-AS1 and ZC3H13 expression was restricted in PCa tumors. The invasion, proliferation and migratory capacities of PCa cells could be inhibited by up-regulating A1BG-AS1 or by co-culturing with exosomes that up-regulate A1BG-AS1. Additionally, ZC3H13 promoted stable A1BG-AS1 expression by regulating the m6A level of A1BG-AS1. Conclusion Exosomal A1BG-AS1 was m6A-modified by the m6A methyltransferase ZC3H13 to stabilize expression and thus prevent PCa cell malignancy. These findings offer a possible target for clinical therapy of PCa.

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Section: Discussionmentioning

confidence: 99%

Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification

Yang,

Luo,

Zhang

et al. 2024

Cell Div

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“…LncRNA LOXL1-AS1 attenuates the in ammatory response of epicardial adipose tissue in coronary artery disease via the sponge uptake of miR-3614 [32]. LncRNA A1BG-AS1 increases FLOT1 expression and promotes breast cancer development by sponging microRNA-485-5p [33]. The co-expression network showed the association of A1BG-AS1 and DBH-AS1 with CIITA and SLAMF1.…”

Section: Discussionmentioning

confidence: 98%

Bioinformatics analysis of the inflammation-associated lncRNA- mRNA co-expression network in type 2 diabetes

Huang

Xiong

Liu

et al. 2022

Preprint

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Background The present study mined key lncRNAs and their functions related to inflammation in type 2 diabetes by constructing a lncRNA-mRNA co-expression network based on bioinformatics technology to discover new markers or therapeutic targets. Results We finally obtained 12 genes, including A1BG-AS1, AC084125.4, RAMP2-AS1, FTX, DBH-AS1, LOXL1-AS1, LINC00893, LINC00894, PVT1, RUSC1-AS1, HCG25, and ATP1B3-AS1. RT-qPCR verified that A1BG-AS1, HCG25, and LOXL1-AS1 were upregulated in the HG + LPS-induced THP-1 cell model, and DBH-AS1 was downregulated in the HG + LPS-induced THP-1 cell model. Conclusions LncRNAs and mRNAs are extensively linked and form a co-expression network, and lncRNAs may influence the development of type 2 diabetes by regulating the corresponding mRNAs. The four key genes obtained may become biomarkers of inflammation in type 2 diabetes in the future.

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“…KCNQ1DN' s DNA methylation is associated with aging ( Koch and Wagner, 2011 ) and its lncRNA was found downregulated in renal cell carcinoma in a in vitro study ( Yang et al, 2019 ). Similarly, A1BG-AS1 is overexpressed in different cancers, including hepatocellular and breast carcinoma ( Bai et al, 2019 ; Cai et al, 2021 ). Other than a specific underlying mechanism of identified signals in the effects of prenatal exposure to green space on cancerogenesis, we speculate that these results may indicate a possible involvement in cell proliferation occurring during the normal development of the offspring.…”

Section: Discussionmentioning

confidence: 99%

Epigenome-wide analysis of maternal exposure to green space during gestation and cord blood DNA methylation in the ENVIRONAGE cohort

Alfano

Bijnens

Langie

et al. 2023

Environmental Research

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Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression

Cited by 10 publications

References 36 publications

Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification

Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification

Bioinformatics analysis of the inflammation-associated lncRNA- mRNA co-expression network in type 2 diabetes

Epigenome-wide analysis of maternal exposure to green space during gestation and cord blood DNA methylation in the ENVIRONAGE cohort

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