Long non‑coding RNA ADAMTS9‑AS2 inhibits liver cancer cell proliferation, migration and invasion

Li, Hanjun; Hu, Huang; Li, Sha; Mei, Hongliang; Cao, Tingjia; Lu, Qiping

doi:10.3892/etm.2021.9991

Cited by 17 publications

(12 citation statements)

References 38 publications

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“…31 ADAMTS9-AS2 inhibited PI3K/AKT/mTOR signaling pathway and thereby suppressed the proliferation, migration, and invasion of hepatocellular carcinoma cells. 32 In this study, based on GESA, ADAMTS9-AS2 was related to pathways including unwinding of DNA, extrinsic pathway, polo-like kinasemediated events, cori cycle, MCM pathway, proteasome pathway, lagging strand synthesis, PCNA-dependent long patch base excision repair and regulation of gene expression in beta cells.…”

Section: Discussionmentioning

confidence: 94%

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

Lin¹,

Huang²,

Yi³

et al. 2021

IJGM

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Section: Discussionmentioning

confidence: 94%

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

Lin¹,

Huang²,

Yi³

et al. 2021

IJGM

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“…For example, ADAMTS9-AS2 is considered as a tumor suppressor in inhibiting the migration of glioma cells, with the regulation by DNMT1 ( 53 ). ADAMTS9-AS2 upregulation also suppresses cancer cell progression in lung cancer ( 54 ), liver cancer ( 55 ), and gastric cancer ( 56 ). LINC00968 serves as oncogenic or tumor-suppressive roles in different cancer types.…”

Section: Discussionmentioning

confidence: 99%

LncRNA-FAM66C Was Identified as a Key Regulator for Modulating Tumor Microenvironment and Hypoxia-Related Pathways in Glioblastoma

Liú

Wan

et al. 2022

Front. Public Health

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Although the role of hypoxia has been greatly explored and unveiled in glioblastoma (GBM), the mechanism of hypoxia-related long non-coding (lnc) RNAs has not been clearly understood. This study aims to reveal the crosstalk among hypoxia-related lncRNAs, tumor microenvironment (TME), and tumorigenesis for GBM. Gene expression profiles of GBM patients were used as a basis for identifying hypoxia-related lncRNAs. Unsupervised consensus clustering was conducted for classifying samples into different molecular subtypes. Gene set enrichment analysis (GSEA) was performed to analyze the enrichment of a series of genes or gene signatures. Three molecular subtypes were constructed based on eight identified hypoxia-related lncRNAs. Oncogenic pathways, such as epithelial mesenchymal transition (EMT), tumor necrosis factor-α (TNF-α) signaling, angiogenesis, hypoxia, P53 signaling, and glycolysis pathways, were significantly enriched in C1 subtype with poor overall survival. C1 subtype showed high immune infiltration and high expression of immune checkpoints. Furthermore, we identified 10 transcription factors (TFs) that were highly correlated with lncRNA-FAM66C. Three key lncRNAs (ADAMTS9-AS2, LINC00968, and LUCAT1) were screened as prognostic biomarkers for GBM. This study shed light on the important role of hypoxia-related lncRNAs for TME modulation and tumorigenesis in GBM. The eight identified hypoxia-related lncRNAs, especially FAM66C may serve as key regulators involving in hypoxia-related pathways.

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“…Currently, several lincRNAs are signi cantly correlated with cancer diagnosis, prognosis, and the therapeutic development of multitype cancers [54][55][56] . Our data indicated that several lincRNAs could function as potential prognostic biomarkers and have important clinical value, e.g., RFPL1S, ADAMTS9-AS2, IBA57-AS1, and MYOSLID are up-regulated lincRNAs [57][58][59][60][61][62] and MORF4L2-AS1, LINC01278, and LINC00562 63-67 are down-regulated. Importantly, all are related to the occurrence and development of several tumors by modulating "PI3K-Akt signaling", "interferon type II signaling" and the expression of particular genes.…”

Section: Discussionmentioning

confidence: 99%

Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database

Shu

2021

Preprint

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Background Breast cancer has remained the most common malignancy in women over the past two decades. As lifestyle and living environments have changed, alterations to the disease spectrum have inevitably occurred in this time. As molecular profiling has become a routine diagnostic and objective indicator of breast cancer etiology, we analyzed changes in gene expression in breast cancer populations over two decades using The Cancer Genome Atlas (TCGA). Methods We performed Heatmap and Venn diagram analyses to identify constantly up- and down-regulated genes in this cohort. We used Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to visualize associated functional pathways. Results We determined that three oncogenes, PD-L2, ETV5, and MTOR and 113 long intergenic non-coding RNAs (lincRNAs) were constantly up-regulated, whereas two oncogenes, BCR and GTF2I, one tumor suppression gene (TSG) MEN1, and 30 lincRNAs were constantly down-regulated. Up-regulated genes were enriched in “focal adhesion” and “PI3K-Akt signaling” pathways, et al, and down-regulated genes were significantly enriched in “metabolic pathways” and “viral myocarditis”. Eight up-regulated genes exhibited doubled or higher expression, and the expression of three down-regulated genes was halved or lowered and correlated with long-term survival. Conclusions In this study, we determined that genes and molecular pathways are constantly changing, importantly, some altered genes were associated with prognostics and are potential therapeutic targets, suggesting molecular typing technologies must keep pace with this dynamic situation.

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Long non‑coding RNA ADAMTS9‑AS2 inhibits liver cancer cell proliferation, migration and invasion

Cited by 17 publications

References 38 publications

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

LncRNA-FAM66C Was Identified as a Key Regulator for Modulating Tumor Microenvironment and Hypoxia-Related Pathways in Glioblastoma

Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database

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