Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells

Niu, Hongyu; Hu, Zhaoyang; Liu, Hui; Hu, Guoliang; Yang, Bo; Wu, Shixiu; Li, Fang

doi:10.1007/s13277-015-4350-x

Cited by 22 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LncRNAs play important roles in various types of cancer and exert multiple functions in cancer cell proliferation, apoptosis, migration, and invasion. [13][14][15] LncRNA HNF1A-AS1 is a novel identied singleexon gene with 2455 nucleotides and localized at the chromosome 12q24.31.…”

Section: -10mentioning

confidence: 99%

MiR-320d suppresses the progression of breast cancervialncRNA HNF1A-AS1 regulation and SOX4 inhibition

Shi

et al. 2018

RSC Adv.

View full text Add to dashboard Cite

MicroRNA-320d (miR-320d) is a novel cancer-related miRNA and functions as a tumor suppressor in human cancers. However, the expression pattern and function of miR-320d in breast cancer remain largely unknown. In the present study, we found that the expression level of miR-320d in breast cancer tissues and cells was significantly lower than in non-tumor tissues and MCF-10A cells. Decreased miR320d was associated with poor overall survival in patients with breast cancer. Overexpression of miR320d inhibited proliferation, migration, and invasion and promoted apoptosis of breast cancer cells. In addition, the long non-coding RNA, HNF1A antisense RNA 1 (HNF1A-AS1) was up-regulated in both breast cancer tissues and cell lines. HNF1A-AS1 suppressed the expression and function of miR-320d.Moreover, SRY-related HMG-box 4 (SOX4) was speculated and confirmed as a target of miR-320d. We also demonstrated that HNF1A-AS1 may function as a sponge competitive endogenous RNA for miR320d, and thus regulate the expression of SOX4. Taken together, our study has identified a novel signaling pathway through which miR-320d exerts its anti-carcinogenic roles and suggested that the HNF1A-AS1/miR-320d/SOX4 may be a potential target for the therapy of breast cancer.

show abstract

Section: -10mentioning

confidence: 99%

MiR-320d suppresses the progression of breast cancervialncRNA HNF1A-AS1 regulation and SOX4 inhibition

Shi

et al. 2018

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…In a study conducted in gastric cancer, Cai et al demonstrated that FRLnc1 overexpression could promote cancer cell migration and metastasis and identified TGF-β1 and Twist as the downstream effectors of FRLnc1 [132]. In CRC, Niu et al revealed that AK027294 downregulation significantly inhibited CRC cell migration and promoted cell apoptosis by regulating Twist, caspase-3, caspase-8, Bcl-2, MMP12, MMP9 expression [133]. In gallbladder cancer, LincRNA-ROR and AFAP1-AS1 are also reported to regulate Twist expression to promote EMT process [134,135].…”

Section: Twist and Lncrnasmentioning

confidence: 99%

Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena

Wang

Yang

Jia

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues. Recently, accumulating evidence indicates that long non-coding RNAs (lncRNAs) represent some of the most differentially expressed transcripts between primary and metastatic cancers. LncRNAs including MALAT1, HOTAIR, H19, LncRNA-ATB, and LincRNA-ROR have been reported to be involved in the process of EMT, mainly through cross-talking with master regulators of EMT. Thus, understanding the different and precise molecular mechanisms by which functional lncRNAs switch EMT on and off is important for opening up new avenues in lncRNA-directed diagnosis, prognosis, and therapeutic intervention against cancer.

show abstract

“…Previous studies have indicated that H19 exhibits dysregulated expression in GC (13,14), hepatocellular carcinoma (15), bladder cancer (16), breast cancer (17) and esophageal cancer (18), and that itmay cause tumor promoting and suppressing effects (19). Niu et al (20) screened lncRNA expression profilesfrom colorectal cancer and adenoma samples, and identified a novel lncRNA, AK027294, which was associated with cell proliferation, migration and apoptosis in colorectal cancer cells. Li et al (21) and Song et al (22) investigated the lncRNA expression patterns in GC with a microarray, and identified 135 differentially expressed lncRNAs in GC tissues compared with non-tumor adjacent tissues (NATs).…”

Section: Introductionmentioning

confidence: 99%

Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells

et al. 2017

View full text Add to dashboard Cite

Abstract. Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target.

show abstract

Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells

Cited by 22 publications

References 23 publications

MiR-320d suppresses the progression of breast cancervialncRNA HNF1A-AS1 regulation and SOX4 inhibition

MiR-320d suppresses the progression of breast cancervialncRNA HNF1A-AS1 regulation and SOX4 inhibition

Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena

Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells

Contact Info

Product

Resources

About