Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer

Sun, Xiufa; Du, Ping; Yuan, Wei; Du, Zhifeng; Yu, Miao; Yu, Xingquan; Hu, Tao

doi:10.1038/cddis.2015.269

Cited by 86 publications

(67 citation statements)

References 33 publications

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“…Multiple previous studies have reported that lncRNAs are involved in cancer pathogenesis and may provide novel insight into the biology of this disease (5,6), where they may act as oncogenes or tumor suppressors. A number of previous studies have reported that HOTAIR may possess pro-oncogenic functions and that it is involved in multiple cancers (8)(9)(10)(11)(12). Similarly, a number of studies have demonstrated that HOTTIP may serve as a critical regulator in certain cancers.…”

Section: Discussionmentioning

confidence: 99%

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Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer

Yang

Yan

et al. 2017

Oncology Letters

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Abstract.A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer. However, the clinical value of HOTTIP expression in gastric cancer remains unknown. The present study aimed to investigate HOTTIP expression levels in gastric cancer and to elucidate its clinical significance. Reverse transcription polymerase chain reaction was used to assess the expression level of HOTTIP in gastric cancer cell lines and tissues. In a cohort of 94 patients with gastric cancer, HOTTIP expression was significantly lower in cancer tissues compared with the normal adjacent tissues. In addition, receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of HOTTIP in gastric cancer, and the area under the ROC curve was 0.767. In conclusion, the results of the present study indicated that HOTTIP may be a predictive biomarker for gastric cancer.

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Section: Discussionmentioning

confidence: 99%

“…HOTAIR is a lncRNA of 2,158 nucleotides in length, which is expressed in the HOXC locus of chromosome 12 (7). It has been reported to be a pro-oncogenic factor and a negative prognostic factor in several types of cancer, including breast, pancreatic, gastric, colorectal and bladder cancer (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer

Yang

Yan

et al. 2017

Oncology Letters

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“…Reduced polycomb protein Mel-18 levels can decrease the expression of miR-205 by promoting methylation of the miR-205 gene, thus contributing to the occurrence of breast cancer[25]. Sun s found that a long non-coding RNA, HOX transcript antisense RNA (HOTAIR), can control miR-205 gene expression, and Guan et al reported that HOTAIR can affect the histone modification status of H3K4me3 and H3K27me3 in its promoter region [26]. To determine whether the expression level of miR-205 is correlated with its methylation status in its promoter region, the methylation status and expression level of miR-205 in 10 strains of cancer cells were detected by BCS and qRT-PCR, respectively.…”

Section: Discussionmentioning

confidence: 99%

Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients

Zou

Jie

et al. 2016

Med Sci Monit

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BackgroundThe expression of miR-205 is closely related to the occurrence, development, and prognosis of lung cancer and breast cancer. However, studies show that it plays opposite roles in different tumor types. Because the expression and regulation of miR-205 are primarily confined to epigenetic areas, whether genetic variation of miR-205 is related to the occurrence or to the development of tumors has not been reported. The aim of this study was to screen genetic variation of miR-205 gene and to investigate its association with the risk and development of lung and breast cancer.Material/MethodsGenomic DNA was extracted from cultured tumor cell lines and formalin-fixed and paraffin-embedded lung and breast tissue samples. Bisulfite Clone Sequencing (BCS) and qRT-PCR were employed to detect the DNA methylation status and gene expression of the miR-205 gene, respectively. Genetic variation of miR-205 and miR-205HG were genotyped with PCR-sequencing method. Immunohistochemical analysis for ER, PR, and HER2 was performed on breast tissue samples.ResultsA polymorphism, rs3842530, located downstream of the miR-205 gene and in the fourth exon of the miR-205 host gene (miR-205HG), was screened. rs3842530 had no correlation with the risk of breast cancer, but was associated with the risk of lung cancer (P<0.05).ConclusionsThese results indicate that the functional association of rs3842530 in miR-205HG and lung cancer might provide a possible explanation for the tissue-dependent function of miR-205 in different tumors.

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“…With the identification of long non-coding RNAs (lncRNAs), it has been demonstrated that certain lncRNAs may serve important roles in BC (5,(7)(8)(9)(10). LncRNAs are a category of non-coding RNAs, containing >200 nucleotides with limited translation potential.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA HNF1A-AS1 promotes cell viability and migration in human bladder cancer

Zhang

Wang

2018

Oncol Lett

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Abstract. Bladder cancer is among the most frequent types of genitourinary malignancies and results in high morbidity and mortality. Despite considerable progress in methods of bladder cancer diagnosis and treatment, the detailed underlying molecular mechanisms of bladder cancer remain unclear, and the prognosis of patients remains poor. In the present study, the role of long non-coding (lnc)RNA hepatocyte nuclear factor 1A (HNF1A)-antisense RNA (AS)1 in bladder cancer progression was examined in vitro. HNF1A-AS1 was overexpressed in clinical bladder cancer tissues and cultured bladder cancer cells. Specific short hairpin RNAs against HNF1A-AS1 knocked down the expression of HNF1A-AS1, and thus suppressed the viability and migration/invasion abilities of the cells. Additionally, the depletion of HNF1A-AS1 in bladder cancer T24 and 5637 cell lines also induced cell accumulation in G 0 /G 1 phase with the cell cycle analysis. Overall, these data suggest that lncRNA HNF1A-AS1 may be a potential regulator of bladder cancer tumorigenesis, and provide novel insight into the diagnosis and treatment of bladder cancer. IntroductionBladder cancer (BC) has the second most frequent incidence of cancers of the genitourinary tract worldwide (1). In 2012 alone, 430,000 incident patients with BC and 165,000 BC-associated mortalities were identified (1). Although advances in treatment have been made in previous decades, the recurrence rate of BC is between 15 and 90% within 5 years, and the 5-year-survival-rate is ~75% (2-5). In total, ~15% of patients with papillary BC develop muscle-invasive and metastatic cancer (3). In these patients, long-term medical care is required, with inevitably high personnel and socioeconomic cost (6). Therefore, it is important to identify novel clues to diagnose and treat BC.With the identification of long non-coding RNAs (lncRNAs), it has been demonstrated that certain lncRNAs may serve important roles in BC (5,7-10). LncRNAs are a category of non-coding RNAs, containing >200 nucleotides with limited translation potential. Unlike other non-coding RNAs, including microRNAs, the underlying molecular mechanisms of different lncRNAs involved in human diseases remain largely unknown. To date, lncRNAs have been demonstrated to participate in multiple intracellular and extracellular activities, including gene transcription, mRNA splicing and tumorigenesis (11)(12)(13)(14)(15). For example, the dysregulation of lncRNAs has been demonstrated in different types of cancer including hepatocellular carcinoma-upregulated lncRNA in hepatocellular carcinoma (16), metastasis-associated lung adenocarcinoma transcript 1 in lung cancer (17) and urothelial cancer-associated 1 and ZEB2 natural antisense transcript in BC (18,19).Unfortunately, despite the increasing implications of lncRNAs in bladder tumorigenesis, no lncRNA has been widely recognized as a specific biomarker for the progression or prognosis of BC. This fact, to a certain extent, encourages focus on novel lncRNAs in BC. Hepatocyte nuclear factor 1A (HNF...

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Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer

Cited by 86 publications

References 33 publications

Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer

Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer

Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients

Long non-coding RNA HNF1A-AS1 promotes cell viability and migration in human bladder cancer

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