Long Non-coding RNA LOXL1-AS1 Facilitates Colorectal Cancer Progression via Regulating miR-1224-5p/miR-761/HK2 Axis

Guo, Tao; Peng, Shihao; Liu, Defeng; Li, Yangyang

doi:10.1007/s10528-022-10226-3

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Further studies have revealed that LOXL1-AS1 enhances the proliferation, migration, invasion and progression of CRC through sponge miR-708-5p regulating CD44-EGFR signal pathway [ 22 ]. Guo et al [ 23 ] found that knocking down LOXL1-AS1 inhibits the CRC cells proliferation, migration, invasion and glycolysis and induces apoptosis in vitro. Silencing LOXL1-AS1 can inhibit CRC tumor growth in vivo.…”

Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

“…In the model of RB xenotransplantation, knocking down LOXL1-AS1 can also significantly inhibit tumor growth and promote tumor cell apoptosis, indicating that LOXL1-AS1 is expected to be the basis for clinical treatment of RB [ 68 ]. LOXL1-AS1 inhibition using shRNA reduce the motor ability of CRC cells and significantly prevent tumor growth in vivo [ 23 ]. As an emerging lncRNA, the research on LOXL1-AS1 is still in pre-clinical stage and more large sample and multicenter studies are needed.…”

Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

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Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Fu,

Ji,

Tang

et al. 2024

Clin Exp Med

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Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides. Despite their inability to code proteins, multiple studies have identified their important role in human cancer through different mechanisms. LncRNA lysyl oxidase like 1 antisense RNA 1 (LOXL1-AS1), a newly discovered lncRNA located on human chromosome 15q24.1, has recently been shown to be involved in the occurrence and progression of various malignancies, such as colorectal cancer, gastric cancer, hepatocellular carcinoma, prostate cancer, non-small cell lung cancer, ovarian cancer, cervical cancer, breast cancer, glioma, thymic carcinoma, pancreatic carcinoma. LOXL1-AS1 acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-374b-5p, miR-21, miR-423-5p, miR-589-5p, miR-28-5p, miR-324-3p, miR-708-5p, miR-143-3p, miR-18b-5p, miR-761, miR-525-5p, miR-541-3p, miR-let-7a-5p, miR-3128, miR-3614-5p, miR-377-3p and miR-1224-5p to promote tumor cell proliferation, invasion, migration, apoptosis, cell cycle, and epithelial–mesenchymal transformation (EMT). In addition, LOXL1-AS1 is involved in the regulation of P13K/AKT and MAPK signaling pathways. This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.

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Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Fu,

Ji,

Tang

et al. 2024

Clin Exp Med

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“…Guo et al ( 23 ) revealed that the levels of LOXL1-AS1 and HK2 were elevated in CRC tissues and cells, while the levels of miR-1224-5p and miR-761 were reduced. Additionally, knocking down LOXL1-AS1 inhibited the proliferation, invasion, migration, and glycolysis of CRC cells and induced apoptosis.…”

Section: Loxl1-as1 and Digestive System Tumoursmentioning

confidence: 99%

Involvement of long non-coding RNA LOXL1-AS1 in the tumourigenesis and development of malignant tumours: a narrative review

Wang,

Liu,

et al. 2024

Transl Cancer Res

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Background and Objective Long noncoding RNAs (lncRNAs) are involved in a wide variety of physiological and pathological processes in organisms. LncRNAs play a significant role as oncogenic or tumour-suppressing factors in various biological processes associated with malignant tumours and are closely linked to the occurrence and development of malignancies. Lysyl oxidase like 1 antisense RNA 1 (LOXL1-AS1) is a recently discovered lncRNA. It is upregulated in various malignant tumours and is associated with pathological characteristics such as tumour size, tumour node metastasis (TNM) staging, lymph node metastasis, and tumour prognosis. LOXL1-AS1 exerts its oncogenic role by competitively binding with multiple microRNAs (miRs), thereby regulating the expression of downstream target genes and controlling relevant signalling pathways. This article aims to explore the structure and the function of LOXL1-AS1, and the relationship between LOXL1-AS1 and the occurrence and development of human malignant tumours to provide a reference for further clinical research. Methods English literature on LOXL1-AS1 in the occurrence and development of various malignant tumours was searched in PubMed. The main search terms were “LOXL1-AS1”, “tumour”. Key Content and Findings This article mainly summarizes the biological processes in which LOXL1-AS1 is involved in various human malignant tumours and the ways in which this lncRNA affects malignant biological behaviours such as proliferation, metastasis, invasion, and apoptosis of tumour cells through different molecular regulatory mechanisms. This article also explores the potential clinical significance and application prospects of LOXL1-AS1, aiming to provide a theoretical basis and reference for the clinical diagnosis, treatment, and screening of prognostic markers for malignant tumours. Conclusions LOXL1-AS1 acts as a competing endogenous RNA (ceRNA), binding to miRs to regulate downstream target genes and exert its oncogenic effects. LOXL1-AS1 may become a novel molecular biomarker for cancer diagnosis and treatment in humans, and it may also serve as an independent prognostic indicator.

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Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis

Yang

Liu

2022

Mol Biotechnol

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Long Non-coding RNA LOXL1-AS1 Facilitates Colorectal Cancer Progression via Regulating miR-1224-5p/miR-761/HK2 Axis

Cited by 6 publications

References 36 publications

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Involvement of long non-coding RNA LOXL1-AS1 in the tumourigenesis and development of malignant tumours: a narrative review

Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis

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