Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer

Abstract

In recent years, with the development of transcriptomics, the effect of long non-coding RNAs (LncRNAs) on the regulation of biological processes is being elucidated. LncRNAs play an important role in tumor occurrence and development. LncRNA associated with microvascular invasion in hepatocellular carcinoma (LncRNA MVIH) was first identified in hepatocellular carcinoma and is associated with angiogenesis, tumor growth and metastasis upregulation, and poor recurrence-free survival. MVIH has an important role in non-small cell lung cancer, in which it promotes cell proliferation and metastasis, and high MVIH expression indicates poor overall survival. However, the involvement of MVIH in breast cancer is unclear. Our research revealed that the expression levels of MVIH in breast cancer tissues were higher than in adjacent noncancerous tissues, and high MVIH expression was correlated with Ki67 expression. Moreover, breast cancer patients with high MVIH expression levels showed poor overall survival and disease-free survival. Multivariate analysis results indicated that MVIH was an independent prognostic factor in breast cancer. In addition, upregulated MVIH expression levels promoted cell proliferation and cell cycle, and inhibited cell apoptosis, while reduced MVIH expression showed the converse. In summary, our findings suggest that MVIH may have an important role in breast cancer and may serve as a new biomarker and a potential therapeutic target.

Identification of long non‐coding RNA MVIH as a prognostic marker and therapeutic target in acute myeloid leukemia

“…[10][11][12][13][14] For instance, some studies display that lncRNA MVIH expression is elevated in HCC tissues as well as breast cancer tissues than that in adjacent non-cancerous tissues. 11,14 Additionally, a study discloses that lncRNA MVIH expression is positively correlated with Karnofsky performance score and World Health Organization (WHO) grade in glioma patients. 10 The predictive role of lncRNA MVIH for prognosis in solid tumors has also been disclosed in some clinical practices.…”

“…10 The predictive role of lncRNA MVIH for prognosis in solid tumors has also been disclosed in some clinical practices. [10][11][12] For instance, lncRNA MVIH high expression is associated with poor disease-free survival and OS in breast cancer patients. 11 Also, lncRNA MVIH high To explore how lncRNA MVIH regulate cell activities in cancers, some in vitro or in vivo experiments are conducted by previous studies.…”

“…8,9 Among them, lncRNA microvascular invasion in hepatocellular carcinoma (MVIH), located on RPS24 gene and encoding a member of the S24E ribosomal proteins, has been reported to correlate with deteriorative disease progression and predict poor survival profiles in several solid tumors, such as hepatocellular carcinoma (HCC), breast cancer, and non-small cell lung cancer (NSCLC). [10][11][12][13][14] Moreover, some experiments have disclosed the ability of lncRNA MVIH to promote cell proliferation and repress apoptosis in several tumors. 10,11,14 All these data emphasized the oncogenic role of lncRNA MVIH in specific solid tumors; however, no evidence about the role of lncRNA MVIH in any hematological malignancies was found, including AML.…”

“…[10][11][12][13][14] Moreover, some experiments have disclosed the ability of lncRNA MVIH to promote cell proliferation and repress apoptosis in several tumors. 10,11,14 All these data emphasized the oncogenic role of lncRNA MVIH in specific solid tumors; however, no evidence about the role of lncRNA MVIH in any hematological malignancies was found, including AML.…”

Increased Expression of Long Non-Coding RNA BCAR4 Is Predictive of Poor Prognosis in Patients with Non-Small Cell Lung Cancer

“…For instance, lncRNA MVIH was found to be significantly upregulated in breast cancer tissues than in adjacent noncancerous tissues, and patients with high MVIH levels showed poor overall survival and disease-free survival (Lei et al 2016). In vitro study revealed that MVIH could promote cell proliferation and cell cycle, while inhibiting apoptosis of breast cancer cells.…”