Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa

Abstract

Objective: The research paid close attention to the function of lncRNA-related endogenous competitive RNAs (ceRNAs) network in endometrial cancer (EC). Methods: 45 primary endometrial cancer tissues (EC) and 45 normal endometrium (NE) were included in the research. The online software StarbaseV2.0 was made use of forecasting the lncRNA which most likely contained microRNA-200c-3p combining sites and could interact with microRNA-200c-3p. Subsequently, we chose lncRNAs which were consistent with the characteristics of polyadenylation of lncRNAs and lower expression in EC than that of NE. After that, lncRNAs, which were related with the microRNA-200c-3p-noxa network, were identified. Results: Rp11-379k17.4, a new gene related to endometrial cancer, was identified as noncoding RNA. It was a more effective ceRNA associated with the microRNA-200c-3p-noxa network. Conclusion: LncRNAs possess microRNA response elements (MREs) and give scope to significant roles in the post-transcriptional mechanism in EC.

lncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity

“…A previous study by the authors demonstrated that miR-205-5p targets the lncRNA LA16c-313D11.11, with one conserved target site in EC. LA16c-313D11.11 may inhibit the expression and activity of miR-205-5p in normal and cancer tissues via this post-transcriptional binding (18). In the present study, LA16c-313D11.11 was shown to modulate a miR-205-5p-PTEN axis in EC.…”

“…A previous study by the authors demonstrated that LA16c-313D11.11 was associated with the nosogenesis of EC and was shown to be a non-coding RNA. LA16c-313D11.11 is an effective ceRNA which is associated with a miRNA-205-5p-PTEN network (18). To further elucidate the molecular mechanisms through which LA16c-313D11.11 may be involved in endometrial cancer, in the present study, 60 primary endometrial cancer tissues, 20 EAH tissues and 20 normal endometrium tissues were obtained for analysis.…”

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

“…Recently, numerous studies have proposed that lncRNAs function a critical role in modulating gene expression at both transcriptional and posttranscriptional levels [ 31 ]. Increasing evidence supported that lncRNAs were implicated in various cancers involving EC development [ 32 ]. For example, lnc-PICSAR affected REV3L expression and improved DDP resistance in cutaneous squamous cell carcinoma [ 24 ].…”

Long Non-coding RNA RP11-395G23.3 Acts as a Competing Endogenous RNA of miR-124-3p to Regulate ROR1 in Anaplastic Thyroid Carcinoma

“…At first, we investigated the detailed function of RP11-395G23.3 in ATC. lncRNA RP11-395G23.3, with the length of 1318 bp, is mapped to the site of 106270144-106272899 of chromosome 8, and is rarely studied, only one research indicates that RP11-395G23.3 plays a crucial role in endometrial carcinogenesis by acting as an endogenous sponge RNA to capture miR-205-5p (Xin et al, 2015), however, the relative research on other cancers is lacking. Here we showed that RP11-395G23.3 level was significantly upregulated in ATC cells compared to control cells, which suggested that RP11-395G23.3 expression is involved in the progression of ATC.…”