Long non-coding RNA TPTEP1 exerts inhibitory effects on hepatocellular carcinoma by impairing microRNA-454-3p-mediated DLG5 downregulation

Dong, Yuandi; Wang, Qingshan; Sun, Jianmin; Liu, Haishi; Wang, Haiyang

doi:10.1016/j.dld.2021.04.014

Cited by 10 publications

(10 citation statements)

References 37 publications

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“…Violin plots, showing the differential expression of each modulated miR, are reported in Supplementary Figure S3 . Of these, several, including miR-483-5p [ 15 ], mir122-5p [ 16 , 17 ], miR-454-3p [ 18 , 19 ], miR-376c-3p [ 20 , 21 ], miR-145-5p [ 22 , 23 ], miR-324-5p [ 24 , 25 ] and miR-342 [ 26 ], are considered to be biomarkers of HCC and are involved in HCC growth, metastasis or resistance to chemotherapy. Moreover, miR-122-5p, miR-103-3p and miR-27b-3p have been associated with the signaling pathways relevant in glucose and lipid metabolism.…”

Section: Resultsmentioning

confidence: 99%

Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients

Resaz

Cangelosi

Segalerba

et al. 2021

IJMS

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Glycogen storage disease type Ia (GSDIa) is an inherited metabolic disorder caused by mutations in the enzyme glucose-6-phosphatase-α (G6Pase-α). Affected individuals develop renal and liver complications, including the development of hepatocellular adenoma/carcinoma and kidney failure. The purpose of this study was to identify potential biomarkers of the evolution of the disease in GSDIa patients. To this end, we analyzed the expression of exosomal microRNAs (Exo-miRs) in the plasma exosomes of 45 patients aged 6 to 63 years. Plasma from age-matched normal individuals were used as controls. We found that the altered expression of several Exo-miRs correlates with the pathologic state of the patients and might help to monitor the progression of the disease and the development of late GSDIa-associated complications.

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Section: Resultsmentioning

confidence: 99%

Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients

Resaz

Cangelosi

Segalerba

et al. 2021

IJMS

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“…Studies on prostate cancer cells reported the concurrent involvement of DLG5 in cell proliferation induction and migration suppression, suggesting that DLG5 may act both as an oncogene and a tumor suppressor in the same cancer type (Table 1, Ref. [7][8][9][17][18][19][20][21][22][23][24][25]). Increased DLG5 expression was detected in some advanced-stage hepatocellular carcinoma (HCC) and prostate cancer tissues [9,26], suggesting a cancer-promoting role of DLG5.…”

Section: The Controversial Role Of Dlg5 In Cancermentioning

confidence: 99%

“…Recent studies have explored the involvement of DLG5 in HCC (Table 2, Ref. [19,21,23,24,26]), one of the most frequent cancers worldwide [39]. Analysis of DLG5 expression in HCC tissue samples evidenced the higher expression in non-tumor tissues, meanwhile, only 28% of HCCs expressed DLG5, mainly at TNM stage I-II [19].…”

Section: Dlg5 Role In Hepatocellular Carcinomamentioning

confidence: 99%

“…4), resulting in invadopodia formation [19,41]. Another recent study identified a DLG5 regulatory pathway involving non-coding RNAs (ncRNAs) [24]. The long non-coding RNA (lncRNA) Transmembrane Phosphatase With Tensin Homology Pseudogene 1 (TPTEP1), was shown to be downregulated in the tumor compared to the adjacent non-tumoral tissue [24].…”

Section: Dlg5 Role In Hepatocellular Carcinomamentioning

confidence: 99%

“…Another recent study identified a DLG5 regulatory pathway involving non-coding RNAs (ncRNAs) [24]. The long non-coding RNA (lncRNA) Transmembrane Phosphatase With Tensin Homology Pseudogene 1 (TPTEP1), was shown to be downregulated in the tumor compared to the adjacent non-tumoral tissue [24]. The lncRNA TPTEP1 sponges miR-454-3p, a microRNA (miRNA) able to promote proliferation, invasion, and EMT, by targeting DLG5.…”

Section: Dlg5 Role In Hepatocellular Carcinomamentioning

confidence: 99%

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Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma

Andolfi¹,

Tiribelli²,

Pascut³

2022

Front. Biosci. (Landmark Ed)

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Discs large MAGUK scaffold protein 5 (DLG5) is a multi-domain member of membrane-associated guanylate kinase (MAGUK) family, which plays a major role in the maintenance of cell epithelial polarity being part of the SCRIB-LGL-DLG complex. Although polarity proteins have been generally considered tumor suppressors, recent discoveries led to reconsidering their role in cancer. This is also true for DLG5 in different cancer types, including hepatocellular carcinoma (HCC). In this cancer, DLG5 was negatively associated with malignant characteristics, however recent findings associated DLG5 expression with advanced stages of HCC. In vitro studies evidenced its possible role in sustaining cell growth and migration by the interaction with several intracellular pathways, such as Hippo, Hedgehog, and PI3K/AKT signaling pathways. In this review, we summarize the recent finding on the dual role of DLG5 and other polarity proteins in cancers. What emerges is a still undefined role of those proteins in cancers, especially in HCC, one of the most frequent cancers worldwide, where the function of DLG5 and other polarity proteins is still largely unexplored.

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Oncogenic roles of LINC01234 in various forms of human cancer

Kong

Zheng

et al. 2022

Biomedicine & Pharmacotherapy

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Long non-coding RNA TPTEP1 exerts inhibitory effects on hepatocellular carcinoma by impairing microRNA-454-3p-mediated DLG5 downregulation

Cited by 10 publications

References 37 publications

Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients

Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients

Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma

Oncogenic roles of LINC01234 in various forms of human cancer

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