Long Non-Coding RNAs and Their Roles in Non-Small-Cell Lung Cancer

Wei, Mingming

doi:10.1016/j.gpb.2016.03.007

Cited by 114 publications

(100 citation statements)

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“…Accumulating biological roles of lncRNAs have been reported in lung cancer progression . For example, MALAT1 serves as an important regulator of lung cancer .…”

Section: Discussionmentioning

confidence: 99%

LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN

et al. 2020

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Long intergenic nonprotein coding RNA p53‐induced transcript (LINC‐PINT) has been reported to participate in various cancers. Here, we investigated the effects of LINC‐PINT on lung cancer progression. Firstly, in our study, we implied that LINC‐PINT was obviously decreased in NSCLC. Thereafter, in A549 and H1299 cells, LINC‐PINT was upregulated via transfecting LV‐LINC‐PINT. As exhibited, LINC‐PINT repressed cell proliferation and cell colony formation of A549 and H1299 cells. Subsequently, flow cytometry evidenced that A549 and H1299 cell apoptosis was obviously triggered and the cell cycle was arrested in G1 phase. Then, migration and transwell invasion experiments were carried out to detect the cell migration and invasion capacity. We found A549 and H1299 cell migration and invasion capacity were restrained by the upregulation of LINC‐PINT. Meanwhile, we predicted that miR‐543 could function as the target of LINC‐PINT and the association was verified. Moreover, we exhibited that miR‐543 was remarkably increased in lung cancer, which could be regulated by LINC‐PINT negatively. Furthermore, PTEN could act as the downstream target of miR‐543 and upregulation of miR‐543 repressed PTEN, which was reversed by LV‐PINT in A549 and H1299 cells. Finally, xenografts were utilized to confirm the function of LINC‐PINT on lung cancer. All these findings concluded that LINC‐PINT exerted crucial biological roles in NSCLC through sponging miR‐543 and inducing PTEN.

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“…Accumulating biological roles of lncRNAs have been reported in lung cancer progression . For example, MALAT1 serves as an important regulator of lung cancer .…”

Section: Discussionmentioning

confidence: 99%

LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN

et al. 2020

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“…Intronic lncRNAs initiate inside an intron in either direction and terminate without overlapping exons. Finally, the bidirectional lncRNAs are less than 1000 base pairs downstream from the transcription initiation site and are on the complementary strand of protein-coding genes [29-31]. LncRNAs are predominately located in the nucleus, and the functional mechanisms of lncRNAs have not yet well elucidated.…”

Section: Lncrnas In Npcmentioning

confidence: 99%

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Hann²

2018

Cell Physiol Biochem

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Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx and occurring at high frequency in South-eastern Asia and North Africa. Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA molecules and key regulators of developmental, physiological, and pathological processes in humans. Emerging studies have shown that lncRNAs play critical roles in tumorgenicity and cancer prognosis. With the development of deep sequencing analyses, an extensive amount of functional lncRNAs have been discovered in nasopharyngeal carcinoma tissues and cell lines. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of NPC are not fully understood. In this review, we briefly illustrate the concept, identification, functional characterization, and summarize recent advancements of biological functions of lncRNAs with heterogeneous mechanistic characterization and their involvement in NPC. Then, we describe individual lncRNAs that have been associated with tumorgenesis, growth, invasion, cancer stem cell differentiation, metastasis, drug resistance and discuss the strategies of their therapeutic manipulation in NPC. We also review the emerging insights into the role of lncRNAs and their potential as biomarkers and therapeutic targets for novel treatment paradigms. Finally, we highlight the up-to-date of clinical information involving lncRNAs and future directions in the linking lncRNAs to potential gene therapies, and how modifications of lncRNAs can be exploited for prevention and treatment of NPC.

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“…Accumulating evidence suggests that abnormal lncRNA expression is often observed in various cancers and contributes to the initiation and development of several cancers 6,7. For NSCLC, some lncRNAs have been identified to function as oncogenes or tumor suppressors and have potential as diagnostic or prognostic markers for patients with NSCLC 8,9…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132)

Zhang¹,

Yang²,

Qu³

et al. 2018

OTT

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BackgroundLong noncoding RNA (lncRNA) Sox2 overlapping transcript (SOX2OT) has been reported to be upregulated in various types of cancers, including non-small-cell lung cancer (NSCLC). However, the biological role and underlying mechanism of SOX2OT activity in NSCLC remain largely unknown. This study aims to investigate the function and possible molecular mechanisms of SOX2OT in NSCLC.Materials and methodsQuantitative real-time polymerase chain reaction was used to detect SOX2OT expression, and cellular proliferation, migration, and invasion were measured using cell counting kit-8, wound healing, and Transwell invasion assays, respectively. Western blotting was used to determine protein expression. Starbase 2.0 and luciferase reporter assay were utilized to identify the molecular target of SOX2OT.ResultsHere, we discovered that SOX2OT was markedly upregulated in NSCLC tissues and cell lines. Knockdown of SOX2OT inhibited the proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) process in NSCLC cells. Moreover, we explored the regulatory mechanism of SOX2OT and found that SOX2OT directly bound microRNA 132 (miR-132) in NSCLC cells. Importantly, miR-132 inhibition partially reversed the SOX2OT knockdown-mediated inhibitory effect on cell proliferation, migration, invasion, and EMT process. We also found that SOX2OT could regulate zinc finger E-box-binding homeobox 2 (a target of miR-132) expression, which played crucial roles in tumor cell proliferation and invasion.ConclusionThese findings indicated that SOX2OT was a noncoding oncogene that exerted important regulatory functions in NSCLC via sponging miR-132 and might represent a novel strategy for overcoming this disease.

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Long Non-Coding RNAs and Their Roles in Non-Small-Cell Lung Cancer

Cited by 114 publications

References 100 publications

LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN

LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132)

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