Long Non-coding RNAs Diversity in Form and Function: From Microbes to Humans

Toomer, Gabriela; Gan, Huachen; Sztuba-Solińska, Joanna

doi:10.1007/978-3-030-44743-4_1

Cited by 2 publications

(1 citation statement)

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“…By combining next-generation sequencing epitranscriptomic mapping with direct RNA sequencing (using nanopores) and a quantitative reverse transcription and ligation-assisted PCR analysis, Sztuba-Solinska's group was able not only to dissect the exact position of m 6 A and Ψ on PAN RNA but also to quantify the fraction of PAN transcripts that carry these marks. 26,27 They noted that the PAN RNA epitranscriptomic patterns for both signatures vary and depend on the stage of viral replication. Using RNA affinity capture, mass spectrometry, and immunoblotting, they also delineated the cellular epitranscriptomic machinery involved in the installation of m 6 A and Ψ on PAN RNA, which include specific m 6 A writers and erasers and pseudouridine synthase.…”

Section: Rna Chemistry Modifications and Modulationmentioning

confidence: 99%

The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field

et al. 2021

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The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an annual meeting series focused on presenting the latest research achievements involving RNA-based therapeutics and strategies, aiming to expand their current biomedical applications while overcoming the remaining challenges of the burgeoning field of RNA nanotechnology. The most recent online meeting hosted a series of engaging talks and discussions from an international cohort of leading nanotechnologists that focused on RNA modifications and modulation, dynamic RNA structures, overcoming delivery limitations using a variety of innovative platforms and approaches, and addressing the newly explored potential for immunomodulation with programmable nucleic acid nanoparticles. In this Nano Focus, we summarize the main discussion points, conclusions, and future directions identified during this two-day webinar as well as more recent advances to highlight and to accelerate this exciting field.

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