Long non-coding RNAs drive metastatic progression in melanoma (Review)

Akhbari, Pouria; Whitehouse, Adrian; Boyne, James R.

doi:10.3892/ijo.2014.2691

Cited by 9 publications

(6 citation statements)

References 72 publications

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“…These non‐protein‐coding transcripts (longer than 200 nucleotides) were shown to be implicated in tumorigenesis; however, their functions and downstream mechanisms are still largely unknown. As summarized in a recent review (Akhbari et al., ), HOTAIR expression is dramatically upregulated in metastatic versus primary melanoma (Tang et al., ). This upregulation leads to increased transcription of the metalloproteinases MMP2 and MMP9, which favor metastatic spread.…”

Section: Micrornas In Melanoma and Melanoma‐subtype‐specific Micrornasmentioning

confidence: 99%

MicroRNAs in melanocyte and melanoma biology

Mione

Bosserhoff

2015

Pigment Cell Melanoma Res

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Summary The importance of microRNAs as key molecular components of cellular processes is now being recognized. Recent reports have shown that microRNAs regulate processes as diverse as protein expression and nuclear functions inside cells and are able to signal extracellularly, delivered via exosomes, to influence cell fate at a distance. The versatility of microRNAs as molecular tools inspires the design of novel strategies to control gene expression, protein stability, DNA repair and chromatin accessibility that may prove very useful for therapeutic approaches due to the extensive manageability of these small molecules. However, we still lack a comprehensive understanding of the microRNA network and its interactions with the other layers of regulatory elements in cellular and extracellular functions. This knowledge may be necessary before we exploit microRNA versatility in therapeutic settings. To identify rules of interactions between microRNAs and other regulatory systems, we begin by reviewing microRNA activities in a single cell type: the melanocyte, from development to disease.

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Section: Micrornas In Melanoma and Melanoma‐subtype‐specific Micrornasmentioning

confidence: 99%

MicroRNAs in melanocyte and melanoma biology

Mione

Bosserhoff

2015

Pigment Cell Melanoma Res

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“…Overexpression of BANCR in MM promotes the activation of the extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) components of the MAPK pathway, while its knockdown affects the migratory capacity of tumour cells [ 75 , 76 ]. A positive feedback mechanism with the V600E mutation is thought to induce BANCR overexpression, subsequent upregulation of chemokines and increase in melanoma cell motility [ 76 , 77 ].…”

Section: Lncrnas Modulate Melanoma Invasion and Metastasismentioning

confidence: 99%

“…A positive feedback mechanism with the V600E mutation is thought to induce BANCR overexpression, subsequent upregulation of chemokines and increase in melanoma cell motility [76,77].…”

Section: Lncrnas Modulate Melanoma Invasion and Metastasismentioning

confidence: 99%

The Non-Coding Landscape of Cutaneous Malignant Melanoma: A Possible Route to Efficient Targeted Therapy

Lazăr

Dinescu

Costache

2020

Cancers

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Considered to be highly lethal if not diagnosed in early stages, cutaneous malignant melanoma is among the most aggressive and treatment-resistant human cancers, and its incidence continues to rise, largely due to ultraviolet radiation exposure, which is the main carcinogenic factor. Over the years, researchers have started to unveil the molecular mechanisms by which malignant melanoma can be triggered and sustained, in order to establish specific, reliable biomarkers that could aid the prognosis and diagnosis of this fatal disease, and serve as targets for development of novel efficient therapies. The high mutational burden and heterogeneous nature of melanoma shifted the main focus from the genetic landscape to epigenetic and epitranscriptomic modifications, aiming at elucidating the role of non-coding RNA molecules in the fine tuning of melanoma progression. Here we review the contribution of microRNAs and lncRNAs to melanoma invasion, metastasis and acquired drug resistance, highlighting their potential for clinical applications as biomarkers and therapeutic targets.

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“…[41, 42] Others have suggested that SPRY4-IT1 manipulates the RAS/ERK pathway given its membership of the Sprouty family of RAS/ERK inhibitor proteins that prevent the formation of active GTP-RAS. [43] However, these hypotheses still need to be confirmed experimentally.…”

Section: Identification Of Lncrnas In Cutaneous Melanoma and Their Momentioning

confidence: 99%

Long non-coding RNAs in cutaneous melanoma: clinical perspectives

et al. 2017

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Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the pathogenesis of cutaneous melanoma through a variety of pathways and molecular interactions. Some of these lncRNAs are possible biomarkers or therapeutic targets for malignant melanoma.

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Long non-coding RNAs drive metastatic progression in melanoma (Review)

Cited by 9 publications

References 72 publications

MicroRNAs in melanocyte and melanoma biology

MicroRNAs in melanocyte and melanoma biology

The Non-Coding Landscape of Cutaneous Malignant Melanoma: A Possible Route to Efficient Targeted Therapy

Long non-coding RNAs in cutaneous melanoma: clinical perspectives

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