Long non‐coding RNAs: Emerging roles in periodontitis

Xu, Jingchen; Yin, Yuanyuan; Lin, Yao; Tian, Mi; Liu, Ting; Song, Chen

doi:10.1111/jre.12910

Cited by 14 publications

(8 citation statements)

References 119 publications

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“…In recent years, long non-coding RNA (lncRNA) has been proven that participated in the progression of periodontitis [ 15 ]. LncRNAs are a class of transcripts longer than 200 nucleotides that do not encode protein.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

He,

Zheng,

et al. 2023

BMC Oral Health

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Background Periodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its poor prognosis is related to the complex immune response. The progression of periodontitis is closely related to necroptosis, but there is still no systematic study of long non-coding RNA (lncRNA) associated with necroptosis for diagnosis and treatment of periodontitis. Material and methods Transcriptome data and clinical data of periodontitis and healthy populations were obtained from the Gene Expression Omnibus (GEO) database, and necroptosis-related genes were obtained from previously published literature. FactoMineR package in R was used to perform principal component analysis (PCA) for obtaining the necroptosis-related lncRNAs. The core necroptosis-related lncRNAs were screened by the Linear Models for Microarray Data (limma) package in R, PCA principal component analysis and lasso algorithm. These lncRNAs were then used to construct a classifier for periodontitis with logistic regression. The receiver operating characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the model. The CIBERSORT method and ssGSEA algorithm were used to estimate the immune infiltration and immune pathway activation of periodontitis. Spearman’s correlation analysis was used to further verify the correlation between core genes and periodontitis immune microenvironment. The expression level of core genes in human periodontal ligament cells (hPDLCs) was detected by RT-qPCR. Results A total of 10 core necroptosis-related lncRNAs (10-lncRNAs) were identified, including EPB41L4A-AS1, FAM30A, LINC01004, MALAT1, MIAT, OSER1-DT, PCOLCE-AS1, RNF144A-AS1, CARMN, and LINC00582. The classifier for periodontitis was successfully constructed. The Area Under the Curve (AUC) was 0.952, which suggested that the model had good predictive performance. The correlation analysis of 10-lncRNAs and periodontitis immune microenvironment showed that 10-lncRNAs had an impact on the immune infiltration of periodontitis. Notably, the RT-qPCR results showed that the expression level of the 10-lncRNAs obtained was consistent with the chip analysis results. Conclusions The 10-lncRNAs identified from the GEO dataset had a significant impact on the immune infiltration of periodontitis and the classifier based on 10-lncRNAs had good detection efficiency for periodontitis, which provided a new target for diagnosis and treatment of periodontitis.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

He,

Zheng,

et al. 2023

BMC Oral Health

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show abstract

“…Most lncRNAs have been studied in relation to processes such as carcinogenesis, osteogenesis, diabetes, neurological diseases, and cardiovascular diseases [ 98 ], suggesting their important role as regulators in the interaction between pathogens and hosts. Emerging evidence has suggested that long non-coding RNAs (lncRNAs) are linked to alterations in immune-related genes and cell subpopulations, including regulating T cells through FOXP3 [ 99 ], controlling dendritic cell differentiation through STAT3 binding to lncDC [ 100 ], and activating the differentiation of CD4+ and CD8+ T cells [ 101 ]. Their involvement in immune response make them valuable diagnostic, prognostic, and therapeutic targets for several inflammatory diseases.…”

Section: Epigenetic Regulations In the Pathophysiology Of Periodontal...mentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

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Periodontal disease (PD) is one of the most common oral conditions affecting both youths and adults. There are some research works suggesting a high incidence of PD in pregnant women. As an inflammatory disease of bacterial origin, PD may result in the activation of the pathways affecting the course and the pregnancy outcome. The authors, based on the literature review, try to answer the PICO question: Does maternal periodontitis (exposure) influence the incidence of complications rates in pregnancy and the development of systemic diseases in childhood and adult offspring (outcome) in the humans of any race (population) compared to the offspring of mothers with healthy periodontium (comparison)? The authors try to describe the molecular pathways and mechanisms of these interdependencies. There is some evidence that maternal periodontitis may affect the pregnancy course and outcome, resulting in preeclampsia, preterm delivery, vulvovaginitis and low birth weight. It can be suggested that maternal periodontitis may affect offspring epigenome and result in some health consequences in their adult life.

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“…The first is according to the diagnostic information requested, such as predictive, initial diagnostic, prognostic and maintenance biomarkers [ 92 ]. The second one is in the function of the biological type, where it is currently known that there are different types of inflammatory mediators, tissue degradation products, bone resorption markers, microbial agents, proteolytic enzymes [ 91 , 93 ], non-coding RNAs [ 93 , 94 , 95 , 96 ] and single nucleotide polymorphisms (SNPs) [ 97 ] ( Figure 2 ).…”

Section: Oral Biomarkersmentioning

confidence: 99%

Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review

et al. 2023

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The success of a prosthetic treatment is closely related to the periodontal health of the individual. The aim of this article was to review and present the importance of prosthetic restorative materials on the condition of the periodontium, the changes that occur in the composition of the subgingival microbiota and the levels of inflammatory markers in gingival crevicular fluid. Articles on the influence of different prosthetic restorative materials on subgingival microbiota and proinflammatory cytokines were searched for using the keywords “prosthetic biomaterials”, “fixed prosthesis”, “periodontal health”, “subgingival microbiota”, “periodontal biomarkers” and “gingival crevicular fluid” in PubMed/Medline, Science Direct, Scopus and Google Scholar. The type of material used for prosthesis fabrication together with poor marginal and internal fit can result in changes in the composition of the subgingival microbiota, as well as increased accumulation and retention of dentobacterial plaque, thus favoring the development of periodontal disease and prosthetic treatment failure. Biological markers have helped to understand the inflammatory response of different prosthetic materials on periodontal tissues with the main purpose of improving their clinical application in patients who need them. Metal-free ceramic prostheses induce a lower inflammatory response regardless of the fabrication method; however, the use of CAD/CAM systems is recommended for their fabrication. In addition, it is presumed that metal-ceramic prostheses cause changes in the composition of the subgingival microbiota producing a more dysbiotic biofilm with a higher prevalence of periodontopathogenic bacteria, which may further favor periodontal deterioration.

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Long non‐coding RNAs: Emerging roles in periodontitis

Cited by 14 publications

References 119 publications

RETRACTED ARTICLE: Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

RETRACTED ARTICLE: Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review

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