Long Non-coding RNAs Expression in Renal Cell Carcinoma

Taheri, Mohammad; Omrani, Mir Davood; Ghafouri‐Fard, Soudeh

doi:10.15412/j.jbtw.01061201

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…Recent studies have demonstrated that lncRNA signature can be used as biomarker and target of novel treatment strategies in cancer patients [70,71]. LncRNAs participate in principal cancer-related processes, such as cell proliferation, cell migration, and EMT through the modulation of important signal ing pathways includ ing mTOR and MAPK pathways [38].…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Tasharrofi¹,

Ghafouri‐Fard²

2018

Klin Onkol

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Considering the role of this pathway in the pathogenesis of several cancers, alterations in lncRNA expression lead to changes in MAPK pathway resulting in inhibition of apoptosis and induction of cell proliferation and migration. Moreover, some lncRNAs participate in cross-talk between MAPK and other cancer-related pathways, such as PI3K/Akt pathway through regulation of certain shared proteins between these pathways. Based on the availability of certain anticancer drugs that modulate this pathway, identification of lncRNAs that affect this pathway would help in establishment of effective therapies.Key words: RNA - long noncoding - mitogen-activated protein kinases - signal transduction.

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Section: Discussionmentioning

confidence: 99%

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Tasharrofi¹,

Ghafouri‐Fard²

2018

Klin Onkol

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“…Long noncoding RNAs (lncRNAs) are involved in many aspects of cell physiology including DNA repair, cell cycle regulation, cell migration, and cell survival. 1,2 Dysregulation of these processes might lead to the development of cancer. Consequently, several studies aimed at expression profiling of lncRNAs in tumoral tissues compared with non-tumoral tissues of the same origin to find the underlying mechanism of tumorigenesis and identify appropriate biomarkers to predict cancer course.…”

Section: Introductionmentioning

confidence: 99%

Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

Ghafouri‐Fard

Taheri

Oskooei

2019

J of Cellular Biochemistry

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“…Among putative bio markers for lung cancer are long non-coding RNAs (lncRNAs). These heterogeneous types of transcripts have various fundamental functions in gene regulation and are involved in the pathogenesis of human cancers [6][7][8][9][10][11]. A comprehensive study to find the lncRNA and mRNA signature in lung adenocarcinoma samples and normal tissues has identified more than two thousands lncRNAs with differential expression in these two sets of samples [12].…”

Section: Introductionmentioning

confidence: 99%

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

Esfandi¹,

Oskooei²,

Taheri³

et al. 2018

Klin Onkol

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Background: Lung cancer as the most fatal cancer of men has prompted researchers to find bio markers for early detection and prognosis. Among the possible bio markers are a group of non-coding transcripts with sizes more than 200 nucleotides called long non-coding RNAs (lncRNAs). Aims: In the present study, we evaluated the expression levels of the lncRNA OIP5 antisense RNA 1 (OIP5-AS1) in 32 non-small cell lung cancer (NSCLC) samples compared with their corresponding adjacent non-cancerous tissue (ANCTs) by means of real-time polymerase chain reaction. The samples were obtained from patients who were admitted at Labbafi-Nejad Hospital during 2015 and 2016. Results: OIP5-AS expression levels was significantly decreased in tumoral tissues compared with ANCTs in total samples and in male subgroup. However, no association was found between relative expression of OIP5-AS1 and clinicopathological data of patients or history of smoking. Expression levels of this lncRNA were not correlated with patients' age. Conclusions: This lncRNA is possibly a novel bio marker of NSCLC in Iranian patients. Future studies are needed to confirm the results of our study in larger sample sizes. Moreover, based on the difference in lung cancer associated risk factors in different populations, population-based studies are needed to explore the role of this lncRNA in the pathogenesis of cancers in each region to design appropriate targeted therapies for each population.

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Long Non-coding RNAs Expression in Renal Cell Carcinoma

Cited by 8 publications

References 16 publications

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

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