Long non‐coding <scp>RNA <i>CASC8</i></scp> polymorphisms are associated with the risk of esophageal cancer in a Chinese population

Sang, Yonghua; Gu, Heng; Chen, Yongbing; Shi, Yijun; Liu, Chao; Lv, Le; Sun, Yifeng; Zhang, Yongsheng

doi:10.1111/1759-7714.13612

Cited by 7 publications

(5 citation statements)

References 31 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, we verified the clinical significance of the four sARLNRs and found that the expression levels of CASC8 and AC015660.1 were significantly higher in PAAD cell lines and tumor tissues especially in patients with advanced grades and T-stages, while Z97832.2 and PAN3-AS1 were inverse. LncRNA-CASC8 polymorphisms have been demonstrated to increase the risk of esophageal cancer and lung adenocarcinoma [ 32 , 33 ], but the role in PAAD is first revealed in the present study. AC015660.1 was identified as a novel inflammation-related lncRNAs to predict the prognosis of gastric carcinoma patients [ 34 ], furthermore, we demonstrate its potential, as an angiogenesis-related lncRNA, for assessing PAAD prognosis here.…”

Section: Discussionmentioning

confidence: 59%

A novel risk score model based on four angiogenesis long non-coding RNAs for prognosis evaluation of pancreatic adenocarcinoma

Cao¹,

Chang²,

Yang³

et al. 2022

Aging

View full text Add to dashboard Cite

Background: Long non-coding RNAs (lncRNAs) have been reported to play significant roles in tumour angiogenesis which prominently facilitates pancreatic adenocarcinoma (PAAD) progression. Methods: The clinical PAAD data were obtained from TCGA database and clinical specimens of 122 PAAD patients. The Molecular Signatures Database v4.0 was used to identify angiogenesis-related long non-coding RNAs (ARLNRs). Survival-related ARLNRs (sARLNRs) were further validated by univariate and multivariate COX regression analyses. The expressions of CASC8, AC015660.1, Z97832.2 and PAN3-AS1 in PAAD cell lines and tissues were examined by qPCR. The correlations between sARLNRs (CASC8 and AC015660.1) and clinicopathological characteristics of the 122 PAAD patients were analyzed by the chi-square test and Fisher's exact probability method.Results: 590 lncRNAs were identified as ARLNRs, of which four sARLNRs were further used to establish an angiogenesis-related risk score model (ARRS), by which patients in the low-risk group have better survival probabilities than those in the high-risk group. The expression levels of CASC8 and AC015660.1 were significantly higher in PAAD cell lines and tumor tissues especially in patients with advanced grades and T-stages, while Z97832.2 and PAN3-AS1 were inverse. In addition, the higher expression of CASC8 and AC015660.1 prominently associated with the larger tumour size, and the more advanced grade and T-stage. However, the relevance between the sARLNRs (CASC8 and AC015660.1) expression and lymph node metastasis status was not significant. Conclusions: In the study, we illuminate the clinical significance, angiogenesis relevance and prognosis-predictive value of four sARLNRs for PAAD. The results build a bridge between sARLNRs and tumour vascularization, and also establish a reliable and accurate risk scoring model for PAAD antiangiogenic strategy.

show abstract

Section: Discussionmentioning

confidence: 59%

A novel risk score model based on four angiogenesis long non-coding RNAs for prognosis evaluation of pancreatic adenocarcinoma

Cao¹,

Chang²,

Yang³

et al. 2022

Aging

View full text Add to dashboard Cite

show abstract

“…In addition, among central nervous system tumors, LINC01088 exerts pro-oncogenic activities in glioma via binding to SNRPA and regulating SNRPA mRNA transcription [ 37 ]. A previous study has proven the effect of the CASC8 rs1562430 polymorphism on esophageal squamous cell carcinoma (ESCC) susceptibility and discovered that functional polymorphisms in CASC8 rs1562430 A > G may influence an individual’s susceptibility to ESCC [ 38 ]. The USP21/YY1/SNHG16 axis is involved in the proliferation, migration, and invasion of non-small-cell lung cancer (NSCLC) [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Identifying Oxidized Lipid Metabolism-Related LncRNAs as Prognostic Biomarkers of Head and Neck Squamous Cell Carcinoma

Zhang

Kim

Han

et al. 2023

JPM

View full text Add to dashboard Cite

The relationship between oxidized lipid metabolism and the immunological function of cancer is well known. However, the functions and regulatory mechanisms of lncRNAs associated with oxidized lipid metabolism in head and neck squamous cell carcinoma (HNSCC) remain to be fully elucidated. In this study, we established an oxidized lipid metabolism-related lncRNA prognostic signature to assess the prognosis and immune infiltration of HNSCC patients. The HNSCC transcriptome was obtained from The Cancer Genome Atlas. The choice of the target genes with a relevance score greater than 10 was performed via a correlation analysis by GeneCards. Patients were categorized by risk score and generated with multivariate Cox regression, which was then validated and evaluated using the Kaplan–Meier analysis and time-dependent receiver operating characteristics (ROC). A nomogram was constructed by combining the risk score with the clinical data. We constructed a risk score with 24 oxidized lipid metabolism-related lncRNAs. The areas’ 1-, 2-, and 3-year OS under the ROC curve (AUC) were 0.765, 0.724, and 0.724, respectively. Furthermore, the nomogram clearly distinguished the survival probabilities of patients in high- and low-risk groups, between which substantial variations were revealed by immune infiltration analysis. The results supported the fact that oxidized lipid metabolism-related lncRNAs might predict prognoses and assist with differentiating amid differences in immune infiltration in HNSCC.

show abstract

“…In another study, Huang et al ( 51 ) reported that overexpression of LINC01133 was associated with poorer prognosis in patients with PAAD and that the C/EBPβ-LINC01133 axis served an oncogenic function through upregulation of CCNG1. CASC8 was reported to be correlated with the progression of non-small cell lung cancer ( 52 ), retinoblastoma ( 53 ) and several other cancers ( 54 , 55 ). Upregulation of CASC8 was reported to be associated with the poor prognosis of patients with PAAD ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a novel ferroptosis‑related lncRNA prognostic signature for pancreatic adenocarcinoma

Wang

et al. 2023

Mol Med Rep

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) serve a pivotal role in the regulation of cancer cell ferroptosis. However, the prognostic value of ferroptosis-related lncRNAs in pancreatic adenocarcinoma (PAAD) largely remains unclear. We aimed at constructing a lncRNA-based signature to improve the prognosis prediction of PAAD. In the present study, the transcriptome profiling data and clinical information of patients with PAAD were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Gene Consortium (ICGC) databases. Univariate Cox regression analysis of the TCGA cohort demonstrated that 26 ferroptosis-related lncRNAs had significant prognostic value for PAAD (all P<0.01). Least absolute shrinkage and selection operator regression and multivariate Cox proportional hazards regression analyses were performed to construct a prognostic ferroptosis-related lncRNA signature (FRLS) comprising nine ferroptosis-related lncRNAs. The efficacy of this FRLS was verified in the training (TCGA) and validation (ICGC) cohorts. Based on the risk model, high risk scores were significantly correlated with poor overall survival (OS) (hazard ratio, 1.314; 95% confidence interval, 1.218-1.418; P<0.001). The receiver operating characteristic curves and principal component analysis further demonstrated the robust prognostic ability of the FRLS. Furthermore, a nomogram with favorable predictive efficacy for the prediction of OS was constructed based on the FRLS and clinical features. Gene set enrichment analysis demonstrated that the genes in the FRLS participated in a number of cancer-associated immunoregulatory pathways. Importantly, it was demonstrated that immune infiltration and response to cancer immunotherapy differed significantly between the high and low-risk groups according to the FRLS. In conclusion, the risk signature based on the FRLS has potential for the clinical prediction of prognosis and immunotherapy response in patients with PAAD.

show abstract

Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

Cited by 7 publications

References 31 publications

A novel risk score model based on four angiogenesis long non-coding RNAs for prognosis evaluation of pancreatic adenocarcinoma

A novel risk score model based on four angiogenesis long non-coding RNAs for prognosis evaluation of pancreatic adenocarcinoma

Identifying Oxidized Lipid Metabolism-Related LncRNAs as Prognostic Biomarkers of Head and Neck Squamous Cell Carcinoma

Development and validation of a novel ferroptosis‑related lncRNA prognostic signature for pancreatic adenocarcinoma

Contact Info

Product

Resources

About