Long non‐coding <scp>RNA LOC</scp>554202 modulates chordoma cell proliferation and invasion by recruiting <scp>EZH</scp>2 and regulating miR‐31 expression

Ma, Xiangyi; Qi, Shengjin; Duan, Zhenying; Liao, Hongzhan; Yang, Baohua; Wang, Wenbo; Tan, Jie; Li, Qinghua; Xia, Xuewei

doi:10.1111/cpr.12388

Cited by 57 publications

(66 citation statements)

References 30 publications

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“…A previous study revealed an association with the oncogene RNF144B in chordoma. Specifically, EZH2, a binding protein of LOC554202, was positively regulated by LOC554202, leading to the reduced expression of miR-31 (59). Furthermore, the impaired function of miR-31 restored expression of the RNF144B oncogene and maintained the metastasis-promoting activity in vitro (59).…”

Section: Os ---------------------------------------------------------mentioning

confidence: 99%

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

Xin

et al. 2018

Oncol Rep

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The expression levels of microRNA‑31 (miR‑31) and LOC554202 have been previously investigated in colorectal cancer (CRC) and their oncogenic and/or tumor suppressive roles have been described. The aim of the present study was to examine the role of miR‑31 and its host gene LOC554202 in the prognosis of patients with CRC. Patients with CRC treated with oxaliplatin‑based chemotherapy between June 2005 and March 2010 were recruited to the First Affiliated Hospital of China Medical University. Tumor and adjacent mucosal tissues were collected. The detection of miR‑31 and/or LOC554202 was performed with probe hybridization targeting. Correlation analysis was performed among the expression levels of miR‑31, LOC554202, and their association with clinicopathological parameters and/or survival rates. miR‑31 and LOC554202 were expressed at high levels in CRC (P<0.01) compared with adjacent intestinal mucosa. A linear correlation was noted for the two markers in CRC tissues (P<0.01). The expression of miR‑31 was significantly higher in adenocarcinoma than in the adjacent intestinal mucosa (P<0.01), whereas the expression of LOC554202 was significantly higher in the adenocarcinoma and the rectal cancer tissue regions (P<0.01). The high expression levels of miR‑31 and LOC554202 were associated with high disease‑free survival (DFS) and overall survival (OS) rates (P<0.05). Associations between the increase in DFS and OS and the elevated expression levels of miR‑31 and LOC554202 were present in patients with colon cancer but not in patients with rectal cancer (P<0.05). These data indicated that miR‑31 and LOC554202 may be potential markers for evaluation of the prognosis of patients treated with oxaliplatin‑based chemotherapy.

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Section: Os ---------------------------------------------------------mentioning

confidence: 99%

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

Xin

et al. 2018

Oncol Rep

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“…LncRNA MIR31HG, locating at human chromosome 9p21.3 [40] with transcription regulated by methylation of the promoter region [27], was found aberrantly expressed in several types of cancers. Specifically, MIR31HG was found elevated expressed in breast cancer [13], cervical cancer [28], chordoma [16], osteosarcoma [15], lung cancer [2,23,41], OSCC [4], PDAC [7], VSCC [29] and LSCC [36,42,43]. Nevertheless, the expression levels of MIR31HG was reported down-regulated in triple-negative breast cancer (TNBC) cell lines of basal subtype [27], bladder cancer [26], gastric cancer [25], CRC [32,33], and HCC [6].…”

Section: Discussionmentioning

confidence: 99%

“…As the host gene of miR-31, MIR31HG was firstly identified to co-express or modulate the expression of miR-31 in certain cancers [44]. For example, MIR31HG could enhance proliferation, migration and invasion by up-regulating EZH2/miR-31 and then indirectly activating the oncogene RNF144B in chordoma [16]. Yang et al demonstrated that elevated MIR31HG could inhibit miR-31 expression, and increase RhoA in LSCC, and via which promote cell growth, cell cycle and invasion [43].…”

Section: Discussionmentioning

confidence: 99%

“…Akt protein kinase B, CCND1 cyclin D1, CRC , colorectal cancer, E2F1, E2F transcription factor 1, EGFR epidermal growth factor receptor, EMT Epithelial-mesenchymal transition, ERK extracellular regulated protein kinases, ESCC esophageal squamous cell carcinoma, ETS1, ETS proto-oncogene 1, transcription factor, EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit, FIH-1 hypoxia inducible factor 1 subunit alpha inhibitor, FOXM1 forkhead box M1, GSK-3β glycogen synthase kinase-3β, HCC hepatocellular carcinoma, HIF-1α hypoxia inducible factor 1 subunit alpha, HNSCC head and neck squamous cell carcinoma, IFN-α/γ interferon-α/γ, LSCC laryngeal squamous cell cancer, LUAD lung adenocarcinoma, MMP1 matrix metallopeptidase 1, NSCLC Non-small cell lung cancer, NT5E 5′-nucleotidase ecto, OSCC oral squamous cell carcinoma, PDAC pancreatic ductal adenocarcinoma, PI3K phosphoinositide 3-kinase, RASA1 RAS p21 protein activator 1, RhoA ras homolog gene family, member A, ST7L suppression of tumorigenicity 7 like, TGF-β transforming growth factor-β, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, VSCC vulvar squamous cell carcinoma Gastric cancer ↑ / p21, E-cadherin Cell proliferation, migration [33] Gastric cancer ↓ / E2F1 Cell proliferation [24] CRC ↑ / miR-31-5p, MYC, TNF-α/NF-κB, TGF-β, IFN-α/γ EMT [16] CRC ↓ / / Cell proliferation, apoptosis [18] HCC ↓ / miR-575, ST7L Cell proliferation, metastasis [5] Bladder cancer ↓ / / / [25] epithelial-mesenchymal transition (EMT) phenotype [2]. Jin et al identified that MIR31HG was induced by nuclear translocation of NF-κB, and in turn directly bind to IκBα and participated in NF-κB activation, revealing an interaction between MIR31HG and NF-κB in osteogenic differentiation [46].…”

Section: Table 3 Expression Pattern Of Mir31hg In Cancers and Its Intmentioning

confidence: 99%

“…Recently, an increasing number of studies have been exploring the prognostic association between MIR31HG and cancers. Abnormal expression of MIR31HG has been reported in a diverse range of cancer types, including osteosarcoma [15], chordoma [16], colorectal cancer (CRC) [17][18][19], hepatocellular carcinoma (HCC) [6], lung cancer [2,[20][21][22][23][24], gastric cancer [25], bladder cancer [26], pancreatic ductal adenocarcinoma (PDAC) [7], oral squamous cell carcinoma (OSCC) [4], breast cancer [13,27], cervical cancer [28], vulvar squamous cell carcinoma (VSCC) [29], and esophageal squamous cell carcinoma (ESCC) [30,31]. Furthermore, MIR31HG expression was remarkably associated with survival time, tumor-node metastasis (TNM) stage and carcinogenesis of certain cancers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Ren

et al. 2020

Cancer Cell Int

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Background: Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study. Methods: Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses were conducted to measure the relationship between MIR31HG expression and clinical outcomes. Moreover, GEPIA was applied for validation of prognostic value of MIR31HG in tumor patients in TCGA dataset. Results: Overall, seventeen studies with 2573 patients were enrolled. Compared to counterparts, those patients with high MIR31HG expression tended to have shorter RFS. Notably, MIR31HG overexpression predicted unfavorable OS in lung cancer. By contrast, gastrointestinal cancer patients with elevated MIR31HG expression predicted better OS and disease-free survival. Additionally, MIR31HG overexpression was significantly associated with worse clinicopathological features including advanced tumor stage and LNM in lung cancer, but favorable clinical characteristics in gastrointestinal cancer. Moreover, the positive association between MIR31HG and OS in lung cancer was further confirmed in TCGA dataset. Conclusion: Overexpression of MIR31HG suggested remarkable association with poor prognosis in terms of OS, tumor stage, and LNM in lung cancer, but favorable prognosis in gastrointestinal cancer. Therefore, MIR31HG may serve as a promising prognostic biomarker in multiple cancers.

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HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR‐217 expression

Wang

Qin

Guan

et al. 2018

J of Cellular Biochemistry

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Drug resistance is a big obstacle for clinical anti-tumor treatment outcome. However, the role of HOTAIR in drug resistance in gastric cancer (GC) remains unknown. In this study, we showed that overexpression of HOTAIR enhanced paclitaxel and doxorubicin resistance in GC cells. Furthermore, the expression of HOTAIR was upregulated in GC tissues and higher expression of HOTAIR was associated with late stage. In addition, we showed that miR-217 expression was lower in GC tissues compared with the paired non-tumour tissues and downregulated expression of miR-217 was correlated with late stage. Interestingly, the expression of miR-217 was negatively correlated with HOTAIR expression in GC tissues. Ectopic expression of HOTAIR increased GC cell proliferation, cell cycle, and migration. Elevated expression of HOTAIR suppressed miR-217 expression and enhanced GPC5 and PTPN14 expression. Furthermore, we demonstrated that overexpression of miR-217 suppressed paclitaxel and doxorubicin resistance in GC cells. Ectopic expression of HOTAIR promoted drug resistance and increased GC cell proliferation, cell cycle, and migration by targeting miR-217. These data suggested that overexpression of HOTAIR enhanced paclitaxel and doxorubicin resistance in GC cells through inhibiting miR-217 expression.

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Long non‐coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR‐31 expression

Abstract: Our results suggest that LOC554202 may play an important role in the progression of chordoma by the direct upregulation of EZH2 and indirect promotion of RNF144B via miR-31.

Cited by 57 publications

References 30 publications

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR‐217 expression

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