Long non‐coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies of the head and neck. It arises from the nasopharynx epithelium and is associated with high morbidity and mortality. Long non‐coding RNA (lncRNA) have been reported to regulate gene interaction and play critical roles in carcinogenesis and progression. LncRNA‐ROR, a recently identified lncRNA, has been shown to be involved in initiation, progression and metastasis of several tumors, including hepatocellular carcinoma, breast cancer and glioma. However, whether lncRNA‐ROR is associated with the progression of NPC remains unknown. Resistance to radiotherapy and chemotherapy is the primary cause of NPC patients’ death. In this study, we found that lncRNA‐ROR was significantly upregulated in NPC tissues compared with normal tissues. Next, our study proved that lncRNA‐ROR was highly associated with the proliferation, metastasis and apoptosis of NPC. The enrichment of lncRNA‐ROR played a critucal functional role in chemoresistance. The mechanism by which NPC resists chemotherapy might be that lncRNA‐ROR suppress p53 signal pathway. Taken together, these data suggested that lncRNA‐ROR played an important role in the progression of NPC; thereby it might become a therapeutic target and reduce chemoresistance for NPC.

Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena

“…High expression of LincRNA-ROR is observed in multiple cancer types, including breast, bladder, and nasopharyngeal carcinoma [57][58][59]. Ectopic expression of LincRNA-ROR in cancer cells was associated with enhanced migration, invasion and EMT in vitro and metastasis in vivo.…”

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

“…This study demonstrated that lncRNA CCAT1 affected the sensitivity of paclitaxel in NPC cells through miR-181a/CPEB2 associated signaling cascade [75]. LncRNA-regulator of reprogramming (ROR), a recently identified lncRNA, has been shown to be involved in initiation, progression and metastasis of several tumors including NPC [47, 76-78]. LncRNA-ROR, located at chromosome 18q21.31, was first discovered in induced pluripotent stem cells (iPSCs) and was directly regulated by stem cell (SC) markers SOX2, OCT4, NONOG, which were crucial for progression of various human malignancies including NPC [79].…”

“…LncRNA-ROR, located at chromosome 18q21.31, was first discovered in induced pluripotent stem cells (iPSCs) and was directly regulated by stem cell (SC) markers SOX2, OCT4, NONOG, which were crucial for progression of various human malignancies including NPC [79]. LncRNA-ROR was reported to be highly associated with the proliferation and metastasis of NPC [47]. Importantly, the enrichment of lncRNA-ROR played a key role in chemoresistance through mechanism by which lncRNA-ROR suppressed p53 signal pathway [47].…”

The Research Progress of Long Noncoding RNAs in Nasopharyngeal Carcinoma

“…Li et al [51] found that LncRNA-ROR overexpression in human nasopharyngeal carcinoma and nasopharyngeal carcinoma cell lines and found that lncRNA-ROR expression levels were detected by RT-PCR The expression of lncRNA-ROR in nasopharyngeal carcinoma (CNE2, CNE1, 5-8F, 6-10B) was also higher than that in normal nasopharyngeal epithelium NP69 high. Study further demonstrated that lncRNA-ROR by regulating the cell cycle and promote the proliferation of nasopharyngeal carcinoma cells by affecting the epithelial mesenchymal transition and promote cell migration and invasion of nasopharyngeal carcinoma, the study discovers the lncRNA-ROR through the P53 pathway to produce chemotherapy resistance in nasopharyngeal carcinoma cells.…”

“…It shows the characteristics lncRNA-ROR Tissue, cell Invasion, metastasis, chemotherapy-resistant Up-regulation [51] of paternally imprinted, selective expression of the maternal allele, the differentially methylated region is mainly affected by the upstream 4000 bp rich CpG island methylation regulation (DMR). H19 can regulate the growth and development of the embryo, but the expression of H19 is inhibited in the majority of tissues and organs after birth.…”