Long non‐coding <scp>RNAs</scp> in diabetic wound healing: Current research and clinical relevance

Kuai, Le; Jiang, Jingsi; Li, Wei; Li, Bin; Su, Yin

doi:10.1111/iwj.13655

Cited by 21 publications

(12 citation statements)

References 115 publications

(145 reference statements)

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“…Additional studies are necessary to determine whether a compensatory upregulation observed in BCL11B expression in absence of BCL11A is a contributor towards the accelerated healing phenotype. Furthermore, noncoding RNAs such as microRNAs (miRNA) and long noncoding RNAs (lncRNA) have received significant attention recently, owing to their rapidly emerging role in modulating nearly every stage of a healing cascade [75][76][77][78][79]. The characterization of expression of noncoding RNAs in the Bcl11a ep−/− mutant skin might provide additional cues about its mechanistic role in facilitating healing.…”

Section: Discussionmentioning

confidence: 99%

Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo

Bhattacharya

Indra

Ganguli‐Indra

2022

Cells

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Transcriptional regulator BCL11A plays a crucial role in coordinating a suite of developmental processes including skin morphogenesis, barrier functions and lipid metabolism. There is little or no reports so far documenting the role of BCL11A in postnatal adult skin homeostasis and in the physiological process of tissue repair and regeneration. The current study establishes for the first time the in vivo role of epidermal BCL11A in maintaining adult epidermal homeostasis and as a negative regulator of cutaneous wound healing. Conditional ablation of Bcl11a in skin epidermal keratinocytes (Bcl11aep−/−mice) enhances the keratinocyte proliferation and differentiation program, suggesting its critical role in epidermal homeostasis of adult murine skin. Further, loss of keratinocytic BCL11A promotes rapid closure of excisional wounds both in a cell autonomous manner likely via accelerating wound re-epithelialization and in a non-cell autonomous manner by enhancing angiogenesis. The epidermis specific Bcl11a knockout mouse serves as a prototype to gain mechanistic understanding of various downstream pathways converging towards the manifestation of an accelerated healing phenotype upon its deletion.

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Section: Discussionmentioning

confidence: 99%

Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo

Bhattacharya

Indra

Ganguli‐Indra

2022

Cells

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“…103 Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in the pathology of diabetes. 104 The overexpression of lncRNA H19 in DFUs stimulates the synthesis of FN and collagen type I and accelerates wound closure. 105 The negative-pressure wound therapy, that is, the application of subatmospheric pressure to the wound, is beneficial for the healing of DFUs.…”

Section: Treatment Of Diabetic Foot Ulcersmentioning

confidence: 99%

Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: A review

Kanta

Zavaďáková

Sticová

et al. 2022

International Wound Journal

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Metabolism of fibronectin, the protein that plays a key role in the healing of wounds, is changed in the patients with diabetes mellitus. Fibronectin can interact with other proteins and proteoglycans and organise them to form the extracellular matrix, the basis of the granulation tissue in healing wounds. However, diabetic foot ulcers (DFUs) suffer from inadequate deposition of this protein. Degradation prevails over fibronectin synthesis in the proteolytic inflammatory environment in the ulcers. Because of the lack of fibronectin in the wound bed, the assembly of the extracellular matrix and the deposition of the granulation tissue cannot be started. A number of methods have been designed that prevents fibronectin degradation, replace lacking fibronectin or support its formation in non-healing wounds in animal models of diabetes. The aim of this article is to review the metabolism of fibronectin in DFUs and to emphasise that it would be useful to pay more attention to fibronectin matrix assembly in the ulcers when laboratory methods are translated to clinical practice.

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“…However, the specific mechanism of exosomes in skin repair remains unclear. Excessive cell inflammation is a cause of chronic wounds [ 12 ]. Pyroptosis has recently been recognized as a type of programmed cell death.…”

Section: Introductionmentioning

confidence: 99%

Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

Yang

Zhang

et al. 2023

Aging

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Skin wounds caused by diabetes are a major medical problem. Mesenchymal stem cell-derived exosomes hold promise to quicken wound healing due to their ability to transfer certain molecules to target cells, including mRNAs, microRNAs, lncRNAs, and proteins. Nonetheless, the specific mechanisms underlying this impact are not elucidated. Therefore, this research aimed to investigate the effect of MSC-derived exosomes comprising long non-coding RNA (lncRNA) H19 on diabetic skin wound healing. Hair follicle mesenchymal stem cells (HF-MSCs) were effectively isolated and detected, and exosomes (Exo) were also isolated smoothly. Pretreatment with 30 mM glucose for 24 h (HG) could efficiently induce pyroptosis in HaCaT cells. Exosomal H19 enhanced HaCaT proliferation and migration and inhibited pyroptosis by reversing the stimulation of the NLRP3 inflammasome. Injection of exosomes overexpressing lncRNA H19 to diabetic skin wound promoted sustained skin wound healing, whereas sh-H19 exosomes did not have this effect. In conclusion, Exosomes overexpressing H19 promoted HaCaT proliferation, migration and suppressed pyroptosis both in vitro and in vivo . Therefore, HFMSC-derived exosomes that overexpress H19 may be included in strategies for healing diabetic skin wounds.

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Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance

Cited by 21 publications

References 115 publications

Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo

Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo

Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: A review

Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

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