Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis

Wang, Po-Shun; Liu, Zulong; Sweef, Osama; Xie, Jie; Chen, Jing; Zhu, Haining; Zeidler-Erdely, Patti C.; Yang, Chengfeng; Wang, Zhishan

doi:10.1016/j.envint.2024.108494

Cited by 7 publications

(1 citation statement)

References 55 publications

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“…2 ). The functions of lncRNAs in the nucleus include: i) Providing scaffolding for DNA ( 33 ), RNAs and proteins ( 34 ); ii) recruiting chromatin-remodelling complexes to remodel the chromatin ( 35 ); iii) preventing RNA polymerase II from attaching to the gene promoter and interfering with transcription ( 36 ); and iv) alternative splicing ( 37 ). The functions of lncRNAs in the cytoplasm include the following: i) Recruiting proteins that promote mRNA degradation and affect the stability of mRNAs ( 13 ); ii) sequestering specific miRNAs through the competing endogenous RNA (ceRNA) mechanism to regulate translation ( 38 ); iii) interfering with post-translational modifications; and iv) affecting the structure and function of proteins ( 39 ).…”

Section: Introduction To Lncrnasmentioning

confidence: 99%

Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)

Ma,

Liu,

Zhang

et al. 2024

Mol Med Rep

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Spinal diseases, including intervertebral disc degeneration (IDD), ankylosing spondylitis, spinal cord injury and other non-infectious spinal diseases, severely affect the quality of life of patients. Current treatments for IDD and other spinal diseases can only relieve symptoms and do not completely cure the disease. Therefore, there is an urgent need to explore the causes of these diseases and develop new treatment approaches. Long non-coding RNA (lncRNA), a form of non-coding RNA, is abundant in diverse sources, has numerous functions, and plays an important role in the occurrence and development of spinal diseases such as IDD. However, the mechanism of action of lncRNAs has not been fully elucidated, and significant challenges remain in the use of lncRNAs as new therapeutic targets. The present article reviews the sources, classification and functions of lncRNAs, and introduces the role of lncRNAs in spinal diseases, such as IDD, and their therapeutic potential.

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