Long noncoding RNA as a potential diagnostic tool for prostate cancer: a systematic review and meta-analysis

Li, Yexin; Wei, Chunmeng; Huang, Caihong; Qiang, Lei; Zhang, Lulu; Huang, Shengzhu; Liao, Naikai; Liang, Weixia; Cheng, Jian; Wang, Fubo; Mo, Linjian; Li, Longman

doi:10.1080/1354750x.2022.2142293

Cited by 4 publications

(2 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interesting, different pathways are related to cancer. Different genes, coding and non‐coding RNA “are shared” between neurodegeneration and cancer, as already demonstrated 37–39 . Other pathways found deregulated both in PBMCs and LCLs in all ALS patients were “Longevity regulating pathway” and pathways related to viral and bacterial infections such as “Herpes simplex virus 1 infection”, “Human T‐cell leukemia virus 1 infection”, “Human cytomegalovirus infection”, “Pathogenic Escherichia coli infection” and “Shigellosis”.…”

Section: Resultssupporting

confidence: 52%

“…Different genes, coding and non-coding RNA "are shared" between neurodegeneration and cancer, as already demonstrated. [37][38][39] Other pathways found deregulated both in PBMCs and LCLs in all ALS patients were "Longevity regulating pathway" and pathways related to viral and bacterial infections such as "Herpes simplex virus 1 infection", "Human T-cell leukemia virus 1 infection", "Human cytomegalovirus infection", "Pathogenic Escherichia coli infection" and "Shigellosis". Moreover, "Ether lipid metabolism" was deregulated only in TARDBP patients and "Mannose type O-glycan biosynthesis" only in SOD1 patients.…”

Section: Comparison With Pbmc Datamentioning

confidence: 99%

See 1 more Smart Citation

RNA expression profiling in lymphoblastoid cell lines from mutated and non‐mutated amyotrophic lateral sclerosis patients

Garau,

Garofalo,

Dragoni

et al. 2024

The Journal of Gene Medicine

View full text Add to dashboard Cite

BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of upper and lower motor neurons with an unknown etiology. The difficulty of recovering biological material from patients led to employ lymphoblastoid cell lines (LCLs) as a model for ALS because many pathways, typically located in neurons, are also activated in these cells.MethodsTo investigate the expression of coding and long non‐coding RNAs in LCLs, a transcriptomic profiling of sporadic ALS (SALS) and mutated patients (FUS, TARDBP, C9ORF72 and SOD1) and matched controls was realized. Thus, differentially expressed genes (DEGs) were investigated among the different subgroups of patients. Peripheral blood mononuclear cells (PBMCs) were isolated and immortalized into LCLs via Epstein–Barr virus infection; RNA was extracted, and RNA‐sequencing analysis was performed.ResultsGene expression profiles of LCLs were genetic‐background‐specific; indeed, only 12 genes were commonly deregulated in all groups. Nonetheless, pathways enriched by DEGs in each group were also compared, and a total of 89 Kyoto Encyclopedia of Genes and Genomes (KEGG) terms were shared among all patients. Eventually, the similarity of affected pathways was also assessed when our data were matched with a transcriptomic profile realized in the PBMCs of the same patients.ConclusionsWe conclude that LCLs are a good model for the study of RNA deregulation in ALS.

show abstract

Section: Resultssupporting

confidence: 52%

Section: Comparison With Pbmc Datamentioning

confidence: 99%

RNA expression profiling in lymphoblastoid cell lines from mutated and non‐mutated amyotrophic lateral sclerosis patients

Garau,

Garofalo,

Dragoni

et al. 2024

The Journal of Gene Medicine

View full text Add to dashboard Cite

show abstract

An emerging link between lncRNAs and cancer sex dimorphism

Naciri,

Andrade-Ludena,

Yang

et al. 2023

Hum. Genet.

View full text Add to dashboard Cite

The prevalence and progression of cancer differ in males and females, and thus, sexual dimorphism in tumor development directly impacts clinical research and medicine. Long non-coding RNAs (lncRNAs) are increasingly recognized as important players in gene expression and various cellular processes, including cancer development and progression. In recent years, lncRNAs have been implicated in the differences observed in cancer incidence, progression, and treatment responses between men and women. Here, we present a brief overview of the current knowledge regarding the role of lncRNAs in cancer sex dimorphism, focusing on how they affect epigenetic processes in male and female mammalian cells. We discuss the potential mechanisms by which lncRNAs may contribute to sex differences in cancer, including transcriptional control of sex chromosomes, hormonal signaling pathways, and immune responses. We also propose strategies for studying lncRNA functions in cancer sex dimorphism. Furthermore, we emphasize the importance of considering sex as a biological variable in cancer research and the need to investigate the role lncRNAs play in mediating these sex differences. In summary, we highlight the emerging link between lncRNAs and cancer sex dimorphism and their potential as therapeutic targets.

show abstract