Long noncoding RNA CCAT2 can predict metastasis and poor prognosis: A meta-analysis

Fan, Yanghua; Fang, Hua; Ji, Chenxing; Xie, Huan; Xiao, Bing; Zhu, Xingen

doi:10.1016/j.cca.2017.01.016

Cited by 42 publications

(31 citation statements)

References 29 publications

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“…Although these results are consistent with those of previous meta-analyses (40)(41)(42), the present study still has several strengths through careful retrieval and in-depth statistical analysis. To our knowledge, this study is the most comprehensive meta-analysis evaluating the relationship between CCAT2 and cancers in the Chinese population, including assessing the associations between increased CCAT2 levels, clinicopathological data and OS.…”

Section: Discussionsupporting

confidence: 92%

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Tian

2017

Int J Biol Markers

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Section: Discussionsupporting

confidence: 92%

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Tian

2017

Int J Biol Markers

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“…Colon cancer-associated transcript 2 (CCAT2), a novel lncRNA first identified by Ling et al (4), encompasses the rs6983267 single nucleotide polymorphism (SNP) and is highly overexpressed in microsatellite-stable colorectal cancer. A meta-analysis demonstrated that high expression of CCAT2 may serve as a novel biomarker of poor prognosis and metastasis in various cancer types (5). Two previous experimental studies examining the association of CCAT2 and GC confirmed that a high expression of CCAT2 was closely associated with a higher incidence of lymph node and distant metastases, as well as shorter overall and progression-free survival rates (6,7).…”

Section: Introductionmentioning

confidence: 99%

Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells

Lee

et al. 2017

Oncol Lett

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The role of long non-coding RNAs (lncRNAs) in the carcinogenesis and progression of tumors has been receiving increasing attention. Colon cancer-associated transcript 2 (CCAT2), a type of oncogenic lncRNA, is regarded as a novel biomarker of poor prognosis and metastasis in various types of cancer. However, the molecular contributions of CCAT2 to gastric cancer (GC) progression remain largely unclear. The aim of the present study was to demonstrate the effect of silencing CCAT2 on the biological behavior of GC BGC-823 cells and illustrate the potential underlying molecular mechanisms. A short hairpin RNA interference plasmid pRNAT-U6.1-CCAT2 targeting CCAT2 was successfully constructed. At 48 h after transfection with the interference plasmid, the survival rate of BGC-823 cells was significantly decreased, as determined by the MTT assay. In addition, RT-qPCR results revealed that CCAT2 gene expression was effectively suppressed by the transfection, while POU domain class 5 transcription factor 1B (POU5F1B) gene expression was significantly decreased. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay further revealed that the apoptotic index was significantly higher in the interference group. Western blot analysis also demonstrated that the expression of beclin-1 protein was significantly increased, whereas the expression levels of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) proteins were downregulated in the interference group. In conclusion, CCAT2 was able to positively regulate the expression of POU5F1B gene. Furthermore, silencing of CCAT2 gene inhibited the proliferation of BGC-823 cells, as well as induced apoptosis and autophagy in BGC-823 cells, by suppression of the PI3K/mTOR signaling pathways.

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“…Some lncRNAs play a vital role in cancer progression, affecting proliferation, invasion and metastasis [ 9 – 10 ]. This suggests LncRNAs may be a useful marker of cancer prognosis and metastasis [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA TUG1 as a potential prognostic biomarker in human cancers: a meta-analysis

Guan

et al. 2017

Oncotarget

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LncRNA taurine upregulated gene 1 (TUG1) is reportedly dysregulated in various cancers. We performed this meta-analysis to clarify the usefulness of TUG1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Jan 11, 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between TUG1 expression and overall survival (OS). Odds ratios (ORs) were calculated to assess the association between TUG1 expression and pathological parameters. Thirteen original studies covering 1,274 cancer patients were included in this meta-analysis. The pooled HR suggested that high TUG1 expression correlated with poor OS (pooled HR=1.41, 95% CI: 1.01-1.98) in cancer types other than non-small cell lung cancer. TUG1 expression was also related to distant metastasis (OR=3.24, 95% CI: 1.18-8.93), large tumor size (OR=4.07, 95% CI: 1.08-15.28) and advanced tumor stage (OR=3.45, 95% CI: 2.19-5.44). Begg’s funnel plot and Egger’s test showed no evidence of obvious asymmetry for overall survival or tumor stage. Thus high TUG1 expression appears predictive of poor OS, distant metastasis, advanced tumor stage and large tumor size. This suggests TUG1 expression could serve as a biomarker for poor prognosis in cancers.

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Long noncoding RNA CCAT2 can predict metastasis and poor prognosis: A meta-analysis

Cited by 42 publications

References 29 publications

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells

Long non-coding RNA TUG1 as a potential prognostic biomarker in human cancers: a meta-analysis

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