Long noncoding RNA ENST00000455974 plays an oncogenic role through up-regulating JAG2 in human DNA mismatch repair-proficient colon cancer

Lao, Yueqiong; Li, Qian; Li, Nanshan; Liu, Hong; Liu, Kuiliang; Jiang, Guojun; Wu, Nan; Wang, Canghai; Wang, Yadan; Wu, Jing

doi:10.1016/j.bbrc.2018.11.088

Cited by 13 publications

(14 citation statements)

References 29 publications

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“…In a recent publication, Lao et al have described the gradual elevation of expression of a novel lncRNA, AC123023.1-201 (ENST0000455974) along the colonic normal-adenoma-dysplasia-carcinoma-metastasis sequence[111]. High levels of this lncRNA were found to be significantly associated with poor survival of DNA mismatch repair proficient (pMMR) CRC patients.…”

Section: Lncrna Expression Alterations In Colorectal Adenoma and Cancmentioning

confidence: 99%

“…High levels of this lncRNA were found to be significantly associated with poor survival of DNA mismatch repair proficient (pMMR) CRC patients. In vitro studies suggest that AC123023.1-201 might exert an oncogenic role in the pathomechanism of pMMR CRC via promoting JAG2-mediated Notch signaling[111].…”

Section: Lncrna Expression Alterations In Colorectal Adenoma and Cancmentioning

confidence: 99%

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Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

Galamb¹,

Barták²,

Kalmár³

et al. 2019

WJG

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Long non-coding RNAs (lncRNAs) are members of the non-protein coding RNA family longer than 200 nucleotides. They participate in the regulation of gene and protein expression influencing apoptosis, cell proliferation and immune responses, thereby playing a critical role in the development and progression of various cancers, including colorectal cancer (CRC). As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality, its screening and early detection are crucial, so the identification of disease-specific biomarkers is necessary. LncRNAs are promising candidates as they are involved in carcinogenesis, and certain lncRNAs (e.g., CCAT1, CRNDE, CRCAL1-4) show altered expression in adenomas, making them potential early diagnostic markers. In addition to being useful as tissue-specific markers, analysis of circulating lncRNAs (e.g., CCAT1, CCAT2, BLACAT1, CRNDE, NEAT1, UCA1) in peripheral blood offers the possibility to establish minimally invasive, liquid biopsy-based diagnostic tests. This review article aims to describe the origin, structure, and functions of lncRNAs and to discuss their contribution to CRC development. Moreover, our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC.

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Section: Lncrna Expression Alterations In Colorectal Adenoma and Cancmentioning

confidence: 99%

Section: Lncrna Expression Alterations In Colorectal Adenoma and Cancmentioning

confidence: 99%

Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

Galamb¹,

Barták²,

Kalmár³

et al. 2019

WJG

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show abstract

“…Long noncoding RNAs (lncRNAs) are a kind of non-coding RNAs of over 200 nucleotides and have little or no protein-coding ability [ 6 ]. Abnormal expression of particular lncRNAs has been demonstrated to be related with development of human diseases.…”

Section: Introductionmentioning

confidence: 99%

LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis

Lin

et al. 2020

J Transl Med

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Background Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to play an essential role in non-alcoholic fatty liver disease. However, the role of NEAT1 in regulation of alcoholic steatohepatitis (ASH) remains largely unknown. This study aims to explore the role of NEAT1 in ASH by mediating microRNA-129-5p (miR-129-5p) targeting suppressor of cytokine signaling 2 (SOCS2). Methods NEAT1, miR-129-5p and SOCS2 expression in serum of ASH patients were assessed. In the in vitro cellular experiment, we transfected siRNAs, oligonucleotides or plasmids into ethanol-induced AML-12 mouse hepatocytes to alter NEAT1 and miR-129-5p expression, and inflammatory factors and lipid content were determined. In the in vivo animal experiment, we injected lentiviruses carrying siRNAs, oligonucleotides or plasmids onto ASH mice (ASH induced by feeding mice a Lieber-DeCarli ethanol diet) to alter NEAT1 and miR-129-5p expression through the tail vein. Serum liver function, blood lipids and inflammatory factors were detected; liver histopathology, liver cell apoptosis, and fibrosis were observed. The relationship between NEAT1 and miR-129-5p, or between miR-129-5p and SOCS2 was verified. Results MiR-129-5p was reduced while NEAT1 and SOCS2 were elevated in ASH. Inhibited NEAT1 or elevated miR-129-5p suppressed the elevated lipid metabolism and restrained inflammation reaction in ethanol-stimulated AML-12 cells. The promoted miR-129-5p and inhibited NEAT1 could improve the liver function and repress blood lipid, inflammation reaction, hepatocyte apoptosis and liver fibrosis in ethanol-induced ASH mice. Furthermore, NEAT1 could negatively regulate miR-129-5p to target SOCS2. Conclusion We have found that the inhibited NEAT1 could suppress liver fibrosis in ASH mice by promoting miR-129-5p and restraining SOCS2, thereby decelerating the development of ASH.

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“…The expression levels of LncRNAs were determined using quantitative real-time polymerase chain reaction (qRT-PCR). Seven types of lncRNAs were recognized as tumor promoters [10,11,13,14,[21][22][23][24][25] and six were tumor suppressors [7,9,[26][27][28][29] in CRC patients. The associations between lncRNAs and clinicopathologic parameters in CRC patients are shown in Table 1.…”

Section: Study Parameters and Study Qualitymentioning

confidence: 99%

“…Diagnostic accuracy differed greatly between different lncRNAs. We found that ENST00000455974 detection had the highest sensitivity (95.6%) with a specificity of 81.2% [23] and CRNDE-h detection had the highest specificity (91.5%) with a sensitivity of 70.3% [13]. QUADAS-2 checklist was used to systematically assess the quality of all the included studies.…”

Section: Study Parameters and Study Qualitymentioning

confidence: 99%

Clinical diagnostic value of long non-coding RNAs in Colorectal Cancer: A systematic review and meta-analysis

Bi¹,

Zhang²,

Fan³

et al. 2020

J. Cancer

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Background: Histopathological diagnosis remains the gold standard for the diagnosis of cancer, including colorectal cancer, but it is infeasible when tumor tissue is not available. With the recognition of long non-coding RNAs (lncRNAs), the expression of lncRNAs in serum or tissue samples has been reported as a diagnosis method for some cancers, however, the diagnostic value of lncRNAs for colorectal cancer remains unclear. Methods: A systematic review and meta-analysis were conducted. Eligible studies were identified through a comprehensive literature search in PubMed, PubMed Central, Web of Science, Embase, and Cochrane Library (up to May 05, 2020) according to the selection criteria. Meta-DiSc, Review Manager and STATA were used to analyze the association between lncRNAs expression and the diagnosis of colorectal cancer. Results: Fifteen studies that analyzed the expression of 15 lncRNAs in 1434 CRC patients were included. The summary area under the curve (AUC) of lncRNA for the diagnosis efficacy between patients with and without CRC was estimated to be 0.8629, corresponding to a weighted sensitivity of 0.75 (95% CI: 0.72-0.77), specificity of 0.80 (95%CI: 0.78-0.82). Subgroup analysis illustrated that the AUC of blood-based detection of lncRNA showed 0.8820, pooled DOR: 18.57, while tissue-based analysis showed 0.8203, pooled DOR: 10.47. Blood-based tests were then divided into two categories, plasma-based and serum-based lncRNA testing. Results revealed that the AUC of serum-based detection was 0.9077, pooled DOR: 26.64, and plasma-based detection was 0.5000, pooled DOR: 11.80. Conclusions: This meta-analysis indicates that the aberrantly expressed lncRNAs might serve as potential diagnostic biomarkers for CRC patients and blood-based lncRNA analysis is of higher diagnostic accuracy than tissue-based testing. Moreover, serum-based lncRNA testing achieved higher diagnostic efficacy than plasma-based analysis.

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Long noncoding RNA ENST00000455974 plays an oncogenic role through up-regulating JAG2 in human DNA mismatch repair-proficient colon cancer

Cited by 13 publications

References 29 publications

Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis

Clinical diagnostic value of long non-coding RNAs in Colorectal Cancer: A systematic review and meta-analysis

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