Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Xie, Chengrong; Wang, Fei; Zhang, Sheng; Wang, Fuqiang; Zheng, Sen; Zhao, Li; Lv, Jie; Qi, He-Qiang; Fang, Qinliang; Wang, Xiaomin; Yin, Zhenyu

doi:10.1016/j.omtn.2017.10.018

Cited by 71 publications

(58 citation statements)

References 35 publications

(39 reference statements)

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“…Similarly, lncRNA HOTAIR may function as a ceRNA to regulate HER2 expression through competition for miR‐331‐3p, thus playing an oncogenic role in gastric pathogenesis . Other studies also showed that ceRNAs were involved in the tumorigenesis of multiple cancer types, including prostate, breast, liver and lung cancers and so on . Although ceRNA research is still in its initial stages, exploration of ceRNA interplay in cancer will provide new insight into mechanisms underlying the pathogenesis of cancers.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Zhang

Yang

et al. 2019

Cancer Science

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Long noncoding RNAs (lncRNAs) are emerging as key regulators in cancer initiation and progression. TP53TG1 is a recently identified lncRNA and several studies have shown that TP53TG1 may play the role of tumor suppressor gene or oncogene in different tumors. Nevertheless, the involvement of TP53TG1 in carcinogenesis of pancreatic ductal adenocarcinoma (PDAC) has not been characterized. In our studies, we identified that TP53TG1 was highly expressed in PDAC and was a novel regulator of PDAC development. Knockdown of TP53TG1 inhibited proliferation, induced apoptosis, and decreased migration and invasion in PDAC cells, whereas enhanced expression of TP53TG1 had the opposite effects. Mechanistically, TP53TG1 could directly bind to microRNA (miR)‐96 and effectively function as a sponge for miR‐96, thus antagonizing the functions of miR‐96 and leading to derepression of its endogenous target KRAS, which is a core oncogene in the initiation and maintenance of PDAC. Taken together, these observations imply that TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR‐96 and regulate KRAS expression, which highlights the importance of the complicated miRNA‐lncRNA network in modulating the progression of PDAC.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Zhang

Yang

et al. 2019

Cancer Science

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“…LncRNA in the cytoplasm could provide a multi-hued palette of regulatory capacities at posttranscriptional level, such as impact on the half-life or translation potential of mRNA (Batista and Chang, 2013). Recently, emerging studies pointed out that cytoplasmic lncRNA could function as 'miRNA sponges' to inhibit miRNA function with high efficiency and specificity Salmena et al, 2011;Song and Yin, 2016;Sun et al, 2017;Xie et al, 2017). To clarify whether LINC01436 could function as miRNA sponges, we started with microarray profiling and TCGA data to detect differentially expressed miRNA in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia‐sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR‐30a‐3p in non‐small cell lung cancer

et al. 2019

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Dysregulation of long noncoding RNA (lncRNA) is known to be involved in numerous human diseases, including lung cancer. However, the precise biological functions of most lnc RNA remain to be elucidated. Here, we identified a novel up‐regulated lnc RNA , LINC 01436 (RefSeq: NR _110419.1), in non‐small cell lung cancer ( NSCLC ). High expression of LINC 01436 was significantly associated with poor overall survival. Notably, LINC 01436 expression was transcriptionally repressed by E2F6 under normoxia, and the inhibitory effect was relieved in a hypoxic microenvironment. Gain‐ and loss‐of‐function studies revealed that LINC 01436 acted as a proto‐oncogene by promoting lung cancer cell growth, migration and invasion in vitro . Xenograft tumor assays in nude mice confirmed that LINC 01436 promoted tumor growth and metastasis in vivo . Mechanistically, LINC 01436 exerted biological functions by acting as a microRNA (miR)‐30a‐3p sponge to regulate the expression of its target gene EPAS 1 . Our findings characterize LINC 01436 as a new hypoxia‐sensitive lnc RNA with oncogenic function in NSCLC , suggesting that LINC 01436 may be a potential biomarker for prognosis and a potential target for treatment.

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“…LncRNAs exert their regulatory functions through various mechanisms, including lncRNA‐miRNA interaction, lncRNA‐mRNA interaction. lncRNA‐protein interaction, and epigenetic silencing . Recently, the lncRNA‐miRNA interaction has attracted a lot of interest.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA TUG1 regulates the migration and invasion of trophoblast‐like cells through sponging miR‐204‐5p

Wang

Gao

et al. 2019

Clin Exp Pharma Physio

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Preeclampsia (PE) is a leading cause of maternal and perinatal death. Accumulated evidence suggests that many long non-coding RNAs (lncRNAs) are abnormally expressed in placentas from PE patients, and they may play functional roles in the development of PE. The present study aimed to investigate the functional role TUG1 in PE and explore the potential molecular mechanisms. Clinically, the expression of TUG1 in placental tissues from PE and normal controls was determined. In vitro, human trophoblast HTR-8/SVneo and JAR cells were employed for loss or gain-offunction assays. Our results demonstrate that TUG1 was downregulated in PE placental tissues compared with normal controls. Moreover, downregulation of TUG1 inhibited the migration and invasion of trophoblast-like cells. Bioinformatics analysisand functional assays showed that TUG1 interacted with miR-204-5p and negatively regulated the expression and function of miR-204-5p in trophoblast cells.Furthermore, TUG1-mediated migration and invasion of trophoblast cells was regulated by miR-204-5p. Together, our results suggested that TUG1 regulates trophoblast migration and invasion partly through sponging miR-204-5p, and the TUG1/ miR-204-5p axis could be a potential therapeutic target for the treatment of PE. K E Y W O R D Sinvasion, lncRNA TUG1, miR-204-5p, MMP9, preeclampsia, trophoblast

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Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Cited by 71 publications

References 35 publications

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

Hypoxia‐sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR‐30a‐3p in non‐small cell lung cancer

Long non‐coding RNA TUG1 regulates the migration and invasion of trophoblast‐like cells through sponging miR‐204‐5p

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