Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Kong, Wencheng; Yin, Guowen; Zheng, Shuier; Liu, Xinchun; Zhu, Akao; Zhang, Jian; Shan, Yuqiang; Ying, Rongchao; Jin, Huicheng

doi:10.1016/j.gendis.2021.07.006

Cited by 24 publications

(18 citation statements)

References 103 publications

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“…There are some pivotal lncRNAs that have been identified as promising diagnostic and prognostic biomarkers, such as HOX transcript antisense intergenic RNA (HOTAIR) [17], small nucleolar RNA host gene 1 (SNHG1) [18], and antisense non-coding RNA at the INK4 locus (ANRIL) [19]. Moreover, lncRNAs prognostic value have been well studied in gastric cancer [20,21].…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA AP000695.2 as a Novel Prognostic Biomarker for Gastric Cance

Cheng¹,

Yi²,

Fu³

et al. 2023

Discovery Medicine

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Background: Long non-coding RNA (lncRNA) AP000695.2 (ENSG00000248538) expresses abnormally in various malignancies, what shows its role as oncogene. However, it has not been extensively studied in gastric cancer. The aim of the current study was to explore the clinical value of AP000695.2 to prognose gastric cancer. Methods: The cancer genome atlas (TCGA) and the gene expression profiling interactive analysis (GEPIA) online tool were used to analyze AP000695.2 expression pattern, diagnostic and prognostic role in gastric cancer. Kaplan-Meier and Cox regression analyses were used to assess survival in patients with gastric cancer. Receiver operating curve (ROC) analysis was used to assess AP000695.2 diagnostic capacity. Nomograms were created to predict overall survival (OS) and progression free survival (PFS). Results: LncRNA AP000695.2 was abnormally upregulated in 19 types of malignancy, including gastric cancer. Survival analysis indicated that high expression of AP000695.2 was associated with poor survival of gastric cancer. Multivariate Cox regression analysis verified the independent prognostic value of AP000695.2 to predict OS (HR (hazard ratio): 1.104, 95% CI (confidence interval): 1.035-1.178, p = 0.003) and PFS (HR: 1.170, 95% CI: 1.090-1.256, p < 0.001). ROC analysis indicated a favorable AP000695.2 diagnostic capacity (area under the curve (AUC) = 0.890). Nomograms were also constructed for OS and PFS based on AP000695.2 expression-related risk score. Additionally, AP000695.2 was found to be positively associated with tumor-infiltrating immune cells, including classically activated (M1) macrophages, neutrophils, alternatively activated (M2) macrophages, and natural killer (NK) cells. Conclusions: It was observed that AP000695.2 can be used as a novel biomarker to diagnose or predict survival of gastric patient.

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Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA AP000695.2 as a Novel Prognostic Biomarker for Gastric Cance

Cheng¹,

Yi²,

Fu³

et al. 2023

Discovery Medicine

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“…This radiosensitization is associated with inhibition of GC cell proliferation and promotion of apoptosis (Dragovich and Campen, 2009). Recent studies have shown that a variety of ncRNAs mediate the expression of EGFR in GC, so these ncRNAs can be used as a medium to target and regulate the expression of EGFR, and then promote the apoptosis of GC cells in the process of radiotherapy, thereby improving the sensitivity of GC to radiotherapy (Carlomagno et al, 2017;D'Souza et al, 2020;Kong et al, 2021;Ye et al, 2022;Lazăr et al, 2016) (Figure 2). Therefore, analyzing the regulatory mechanism of ncRNA on EGFR expression is a new direction worth exploring to improve the radiosensitivity of GC, and the EGFR inhibitor derived from this is expected to be a selective and effective radiosensitizer for GC.…”

Section: Activation Of Epidermal Growth Factor Receptor (Egfr) Signal...mentioning

confidence: 99%

Investigations into the impact of non-coding RNA on the sensitivity of gastric cancer to radiotherapy

Usman

Beilerli²,

Sufianov³

et al. 2023

Front. Physiol.

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Non-coding RNAs (ncRNAs) are a newly discovered functional RNA different from messenger RNA, which can participate in regulating the occurrence and development of tumors. More and more research results show that ncRNAs can participate in the regulation of gastric cancer (GC) radiotherapy response, and its mechanism may be related to its effect on DNA damage repair, gastric cancer cell stemness, cell apoptosis, activation of epidermal growth factor receptor signaling pathway, etc. This article summarizes the relevant mechanisms of ncRNAs regulating the response to radiotherapy in gastric cancer, which will be directly important for the introduction of ncRNAs particularly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) into clinical medicine as biomarkers and therapeutic targets.

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“…HOX transcript antisense RNA (HOTAIR) resides within the intergenic region in HOXC cluster on chromosome 12, and acts as a crucial modulator of chromatin re-modeling and transcriptional silencing ( 189 ). As an epigenetic agent, HOTAIR can interact with various factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance ( 190 ). In OA cartilage, HORAIR was upregulated than that of normal samples ( 164 ).…”

Section: Biological Functions Of Lncrnas In Oa Pathogenesismentioning

confidence: 99%

Emerging role of lncRNAs in osteoarthritis: An updated review

2022

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Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The molecular mechanism underlying OA pathogenesis is multifactorial. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with length more than 200 nucleotides. They have various functions such as modulating transcription and protein activity, as well as forming endogenous small interfering RNAs (siRNAs) and microRNA (miRNA) sponges. Emerging evidence suggests that lncRNAs might be involved in the pathogenesis of OA which opens up a new avenue for the development of new biomarkers and therapeutic strategies. The purpose of this review is to summarize the current clinical and basic experiments related to lncRNAs and OA with a focus on the extensively studied H19, GAS5, MALAT1, XIST and HOTAIR. The potential translational value of these lncRNAs as therapeutic targets for OA is also discussed.

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Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Cited by 24 publications

References 103 publications

Long Noncoding RNA AP000695.2 as a Novel Prognostic Biomarker for Gastric Cance

Long Noncoding RNA AP000695.2 as a Novel Prognostic Biomarker for Gastric Cance

Investigations into the impact of non-coding RNA on the sensitivity of gastric cancer to radiotherapy

Emerging role of lncRNAs in osteoarthritis: An updated review

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