Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

Quinodoz, Sofia A.; Guttman, Mitchell

doi:10.1016/j.tcb.2014.08.009

Cited by 298 publications

(233 citation statements)

References 136 publications

(259 reference statements)

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“…Long non-coding RNAs (lncRNAs) are enriched within the chromatin-associated fraction, and many have been implicated in the recruitment of chromatin-modifying complexes, such as polycomb repressive complex 2 (PRC2), as well as 3D nuclear organisation [51]. Using the iCLIP assay, we have found that SAFB1 binds to several lncRNA transcripts (MALAT1, NEAT1, TUG1 and XIST), which have been linked to regulation of gene expression [43].…”

Section: Binding To Non-coding Rnamentioning

confidence: 99%

The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins

Norman

Rivers

Lee

et al. 2016

Biochemical Journal

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RNA-binding proteins play a central role in cellular metabolism by orchestrating the complex interactions of coding, structural and regulatory RNA species. The SAFB (scaffold attachment factor B) proteins (SAFB1, SAFB2 and SAFB-like transcriptional modulator, SLTM), which are highly conserved evolutionarily, were first identified on the basis of their ability to bind scaffold attachment region DNA elements, but attention has subsequently shifted to their RNA-binding and protein-protein interactions. Initial studies identified the involvement of these proteins in the cellular stress response and other aspects of gene regulation. More recently, the multifunctional capabilities of SAFB proteins have shown that they play crucial roles in DNA repair, processing of mRNA and regulatory RNA, as well as in interaction with chromatin-modifying complexes. With the advent of new techniques for identifying RNA-binding sites, enumeration of individual RNA targets has now begun. This review aims to summarise what is currently known about the functions of SAFB proteins.

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Section: Binding To Non-coding Rnamentioning

confidence: 99%

The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins

Norman

Rivers

Lee

et al. 2016

Biochemical Journal

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“…74 In fact, functional studies have revealed that lncRNAs participate in a variety of biological processes, including transcriptional regulation by recruiting chromatin regulatory proteins to specific genomic locations, genomic imprinting, organization of protein complexes, and shaping distinct nuclear structures. 75,76 Recent RNA sequencing studies in mouse and human hearts revealed that lncRNAs are dynamically regulated during disease. 11,[77][78][79] In human hearts, a total number of 18 480 lncRNAs were detected, of which ≈600 were differentially expressed in failing hearts with either ischemic or non-ischemic origin.…”

Section: Lncrnas As New Players In Cardiac Biologymentioning

confidence: 99%

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis

Creemers

Rooij

2016

Circulation Research

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Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is the transformation of fibroblasts into myofibroblasts, which secrete large amounts of extracellular matrix proteins. Although the function of proteincoding genes in myofibroblast activation and fibrosis have been a topic of investigation for a long time, it has become clear that noncoding RNAs also play key roles in cardiac fibrosis. This review discusses the involvement of microRNAs and long noncoding RNAs in cardiac fibrosis and summarizes the issues related to translating these findings into real-life therapies. (Circ Res. 2016;118:108-118.

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“…113 Both Bvht and Fendrr seem to interact with PRC2 to regulate target gene expression during cardiac development. 46,47 Bvht was shown to interact with the catalytic SUZ12 component of PRC2 by in vitro RNA pulldown or RNA-immunoprecipitation experiments in both ESCs and in vitro differentiated cardiac progenitor cells.…”

Section: Interactions With Histone Modifying Complexesmentioning

confidence: 99%

Lnc ing Epigenetic Control of Transcription to Cardiovascular Development and Disease

Rizki

Boyer

2015

Circulation Research

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Transcriptional and epigenetic regulation is critical for proper heart development, cardiac homeostasis, and pathogenesis. Long noncoding RNAs have emerged as key components of the transcriptional regulatory pathways that govern cardiac development as well as stress response, signaling, and remodeling in cardiac pathologies. Within the past few years, studies have identified many long noncoding RNAs in the context of cardiovascular biology and have begun to reveal the key functions of these transcripts. In this review, we discuss the growing roles of long noncoding RNAs in different aspects of cardiovascular development as well as pathological responses during injury or disease. In addition, we discuss diverse mechanisms by which long noncoding RNAs orchestrate cardiac transcriptional programs. Finally, we explore the exciting potential of this novel class of transcripts as biomarkers and novel therapeutic targets for cardiovascular diseases. ( Rizki and Boyer Long Noncoding RNAs in Cardiovascular Biology 193of fetal cardiac and stress response genes. 6,8,9 Despite these findings, transcriptional and epigenetic reprogramming of the failing heart is a complex process and the full spectrum of molecular determinants of these responses are waiting to be identified. Similar to developmental control mechanisms, noncoding RNAs are emerging players in post injury response cascades. In this review, we focus on the surge of recent studies that have begun to uncover the critical roles of lncRNAs in many different aspects of cardiovascular development, physiology, and disease.

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Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

Cited by 298 publications

References 136 publications

The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins

The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis

Lnc ing Epigenetic Control of Transcription to Cardiovascular Development and Disease

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