A highly sensitive torsion sensor can be constructed by combining a twisted photonic crystal fiber with a liquid-filled waveguide in its air-hole cladding. The torsion sensitivity of this type of sensor is determined directly by the phase-matching conditions between the fiber core mode and the liquid waveguide mode, which can be improved by tuning the helicity (denoted by the initial twist rate, α 0 ) of the twisted photonic crystal fiber. The enhancement mechanism of α 0 on the sensitivity of the proposed torsion sensor is investigated theoretically, followed by experimental verifications, and a torsion sensitivity as high as 446 nm·mm·rad −1 can be obtained by tailoring these parameters. Experimental results show that the torsion sensitivity increases with α 0 decreasing from 3.142 to 3.925 rad/mm, which are in consistence with that of the numerical predictions. The demonstrated torsion sensor is expected to contribute to the development of highly sensitive torsion-related photonic crystal fiber devices.