Long QT syndrome caused by adrenal insufficiency secondary to IgG4-related hypophysitis: a case report and review of the literature

Yaku, Ai; Murakami, Kosaku; Mukoyama, Hiroki; Shibuya, Shinsuke; Nakashima, Ran; Hashimoto, Motomu; Yoshifuji, Hajime; Ohmura, Koichiro; Haga, Hironori; Mimori, Tsuneyo

doi:10.1080/24725625.2019.1569798

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…According to the literature, after the first report of pituitary involvement by IgG4‐RD in 2004, 22 more than 20 histopathological‐documented cases of “IgG4‐related hypophysitis” (IgG4‐RH) have been published till now 23 . More than half of the IgG4‐RH patients develop central DI 24,25 . In our case, however, it was the central DI that primarily presented; then, after 14 years, the IgG4‐RD was diagnosed—a proposed sequence of presentation that, to the best knowledge of the authors, has not yet been reported.…”

Section: Discussionmentioning

confidence: 66%

A challenging case report of IgG4‐related systemic disease involving the heart and retroperitoneum with a literature review of similar heart lesions

et al. 2020

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The IgG4‐related disease is a distinct, steroid‐responsive fibro‐inflammatory disorder of unknown etiology. This multiorgan disease is characterized by tumefactive lesions that contain rich infiltrations of IgG4‐positive plasma cells, with the pancreas, and the salivary and lacrimal glands being the main involved. The more common cardiovascular involvements include inflammatory peri‐aortitis, coronary arteritis, and pericarditis. Intra‐cardiac tumefactive lesions are rarely reported. Herein, we describe a challenging case of IgG4‐related disease with a long‐time lag between initiation of symptoms to proper diagnosis with biopsy‐proven cardiac and retroperitoneal and possible pituitary gland involvement. Concerning the rarity of the cardiac lesion in our case, we conducted a literature review of similar case reports.

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Section: Discussionmentioning

confidence: 66%