2004
DOI: 10.1073/pnas.0306002101
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Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation

Abstract: Histone acetylation of promoters precedes activation of many genes. In addition, long-range histone acetylation patterns can be established over many kilobases of the chromatin of linked families of genes that are under common transcriptional control. It is not known whether establishment of long-range histone acetylation patterns is limited to gene families or is a common feature of many genes. The Ifng gene is not known to be a member of a gene family but exhibits complex strain-, cell lineage-, and stimulus… Show more

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Cited by 60 publications
(58 citation statements)
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“…As examples, promoters of both the Ifng and Il4 genes are histone hyperacetylated during active transcription by Th1 and Th2 cells, respectively (27,28). We have investigated alterations in histone hyperacetylation along the Ifng gene region in CD8 ϩ T cells as they differentiate into effector Tc1 cells that actively transcribe the Ifng gene and effector Tc2 cells that do not actively transcribe the Ifng gene (12). The Ifng gene region acquires extensive histone acetylation across the Ϸ140-kb region both 5Ј and 3Ј of the Ϸ5-kb Ifng gene during Tc1 differentiation and active gene transcription.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As examples, promoters of both the Ifng and Il4 genes are histone hyperacetylated during active transcription by Th1 and Th2 cells, respectively (27,28). We have investigated alterations in histone hyperacetylation along the Ifng gene region in CD8 ϩ T cells as they differentiate into effector Tc1 cells that actively transcribe the Ifng gene and effector Tc2 cells that do not actively transcribe the Ifng gene (12). The Ifng gene region acquires extensive histone acetylation across the Ϸ140-kb region both 5Ј and 3Ј of the Ϸ5-kb Ifng gene during Tc1 differentiation and active gene transcription.…”
Section: Discussionmentioning
confidence: 99%
“…Long-range, nonuniform histone hyperacetylation patterns are also formed across the Ifng gene region, a gene not known to be a member of a gene family, during the differentiation processes that lead to tissue-specific transcription in CD8 ϩ T cells (12). One question raised by these studies is whether establishment of long-range histone hyperacetylation patterns across the Ifng gene region reflects a developmental process that is necessary for active gene transcription, a nuclear signaling process that is required for efficient transcription, or both.…”
mentioning
confidence: 99%
“…It was then maintained at high levels in Th1 cells, but gradually lost in Th2 cells. Several reported studies have examined histone modifications at the IFN-␥ gene and the Th2 cytokine gene cluster (12,20,24,(37)(38)(39)(40). These studies examined histone modifications in Th1 and Th2 cells differentiated over a short period time.…”
Section: Discussionmentioning
confidence: 99%
“…Recent published reports have suggested the existence of regulatory sequences at regions 50 kb upstream, and downstream beyond the region of IFNG itself -far more distal than what has been previously assumed. 4 In addition, histone hyperacetylation patterns and alterations in chromatin structure have been demonstrated within 24 kb of IFNG, as cells progress from naive T helper (Th) 0 to IFN-gproducing Th1 cells. 4,5 Inappropriate overexpression of IFN-g by activated mucosal T cells is an important contributory factor in the pathogenesis of inflammatory bowel disease (IBD).…”
Section: Introductionmentioning
confidence: 99%
“…4 In addition, histone hyperacetylation patterns and alterations in chromatin structure have been demonstrated within 24 kb of IFNG, as cells progress from naive T helper (Th) 0 to IFN-gproducing Th1 cells. 4,5 Inappropriate overexpression of IFN-g by activated mucosal T cells is an important contributory factor in the pathogenesis of inflammatory bowel disease (IBD). [6][7][8] In fact, disease severity is correlated with the level of IFN-g expression.…”
Section: Introductionmentioning
confidence: 99%