2021
DOI: 10.1101/2021.10.12.464082
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Long-range migration of centrioles to the apical surface of the olfactory epithelium

Abstract: Olfactory sensory neurons (OSNs) in vertebrates detect odorants using multiple cilia, which protrude from the end of the dendrite and require centrioles for their formation. In mouse olfactory epithelium, the centrioles originate in progenitor cells near the basal lamina, often 50 to 100 μm from the apical surface. It is unknown how centrioles traverse this distance or mature to form cilia. Using high-resolution expansion microscopy, we found that centrioles migrate together, with multiple centrioles per group… Show more

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“…In multi-ciliated cells hundreds of centrioles are produced which must then migrate to the cell cortex to function as basal bodies (Spassky and Meunier, 2017;Jord et al, 2019;Ching et al, 2021). If centriole migration is impaired, then cilia formation is effected, which can result in a range of disorders termed ciliopathies (Reiter and Leroux, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…In multi-ciliated cells hundreds of centrioles are produced which must then migrate to the cell cortex to function as basal bodies (Spassky and Meunier, 2017;Jord et al, 2019;Ching et al, 2021). If centriole migration is impaired, then cilia formation is effected, which can result in a range of disorders termed ciliopathies (Reiter and Leroux, 2017).…”
Section: Introductionmentioning
confidence: 99%