2023
DOI: 10.1016/j.trsl.2022.09.004
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Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

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Cited by 21 publications
(22 citation statements)
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“…However, the mechanisms of HSIL + and LSIL-are different. The mechanism of HSIL + is the persistent infection of HR-HPV, the integration of virus DNA into the human cell genome, and the persistently high expression of E6 and E7 in the host genome [19]. The mechanism of LSIL-is that low-risk HPV E6 and E7 proteins play a less important role in blocking the function of p53 and pRb than HR-HPVE6 and E7 proteins [20].…”
Section: Discussionmentioning
confidence: 99%
“…However, the mechanisms of HSIL + and LSIL-are different. The mechanism of HSIL + is the persistent infection of HR-HPV, the integration of virus DNA into the human cell genome, and the persistently high expression of E6 and E7 in the host genome [19]. The mechanism of LSIL-is that low-risk HPV E6 and E7 proteins play a less important role in blocking the function of p53 and pRb than HR-HPVE6 and E7 proteins [20].…”
Section: Discussionmentioning
confidence: 99%
“…Hence, a possible mechanism underlying this difference is that there are significantly more HPV‐integrated cells in s‐CIN 3 than in s‐VaIN 3. The integration of HPV and host cells is a prerequisite for progression to cancer 31 . Consequently, this difference might explain why the possibility of vaginal intraepithelial neoplasia progressing to vaginal cancer is much lower than that of cervical lesions progressing to cervical cancer.…”
Section: Discussionmentioning
confidence: 99%
“…The formation of a Brd4‐dependent super‐enhancer from tandem repeats integration mechanism has also been reported after HPV 16 infection 18 . Generally, after the integration, spliced viral‐cellular transcripts are mostly produced, being more stable than the viral ones and leading to increased protein expression 17,19 . E6 and E7 act at different levels to induce pro‐tumoral changes in the host cells.…”
Section: Overview Of Key Oncogenic and Immune‐suppressing Mechanisms ...mentioning
confidence: 93%
“…18 Generally, after the integration, spliced viral-cellular transcripts are mostly produced, being more stable than the viral ones and leading to increased protein expression. 17,19 E6 and E7 act at different levels to induce pro-tumoral changes in the host cells. E6 targets p53 and inhibits p53-dependent apoptosis.…”
Section: Overview Of Key Oncogenic and Immune-suppressing Mechanisms ...mentioning
confidence: 99%