Long-term (15 mo) dietary supplementation with pomegranates from Oman attenuates cognitive and behavioral deficits in a transgenic mice model of Alzheimer's disease

Subash, Selvaraju; Braidy, Nady; Essa, Musthafa Mohamed; Zayana, Al Buraiki; Vaishnav, Ragini; Al-Adawi, Samir; Al‐Asmi, Abdullah; Guillemin, Gilles J.

doi:10.1016/j.nut.2014.06.004

Cited by 56 publications

(39 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We recently reported that chronic dietary term supplementation of fruits could be beneficial for behavior and oxidative stress related changes in AD transgenic mice[59606162] which also support our present findings.…”

Section: Discussionsupporting

confidence: 91%

Pomegranate from Oman Alleviates the Brain Oxidative Damage in Transgenic Mouse Model of Alzheimer’s Disease

Subash

Essa

Al‐Asmi

et al. 2014

Journal of Traditional and Complementary Medicine

Self Cite

View full text Add to dashboard Cite

Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Pomegranates (石榴 Shí Liú) contain very high levels of antioxidant polyphenolic substances, as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in different model systems. Here, the effects of the antioxidant-rich pomegranate fruit grown in Oman on brain oxidative stress status were tested in the AD transgenic mouse. The 4-month-old mice with double Swedish APP mutation (APPsw/Tg2576) were purchased from Taconic Farm, NY, USA. Four-month-old Tg2576 mice were fed with 4% pomegranate or control diet for 15 months and then assessed for the influence of diet on oxidative stress. Significant increase in oxidative stress was found in terms of enhanced levels of lipid peroxidation (LPO) and protein carbonyls. Concomitantly, decrease in the activities of antioxidant enzymes was observed in Tg2576 mice treated with control diet. Supplementation with 4% pomegranate attenuated oxidative damage, as evidenced by decreased LPO and protein carbonyl levels and restoration in the activities of the antioxidant enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione (GSH), and Glutathione S transferase (GST)]. The activities of membrane-bound enzymes [Na+ K+-ATPase and acetylcholinesterase (AChE)] were altered in the brain regions of Tg2576 mouse treated with control diet, and 4% pomegranate supplementation was able to restore the activities of enzymes to comparable values observed in controls. The results suggest that the therapeutic potential of 4% pomegranate in the treatment of AD might be associated with counteracting the oxidative stress by the presence of active phytochemicals in it.

show abstract

Section: Discussionsupporting

confidence: 91%

Pomegranate from Oman Alleviates the Brain Oxidative Damage in Transgenic Mouse Model of Alzheimer’s Disease

Subash

Essa

Al‐Asmi

et al. 2014

Journal of Traditional and Complementary Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…A hipótese do "estresse oxidativo" defende que a prevalência de radicais livres é uma das principais causas da neurotoxicidade do peptídeo βA na DA (SUBASH et al, 2015).…”

Section: Estresse Oxidativounclassified

“…A quantificação de MDA vem sendo relatada em trabalhos científicos para determinar o grau de peroxidação lipídica em amostras biológicas (ANTUNES NETO et al, 2008;SUBASH et al, 2015).…”

Section: Peroxidação Lipídicaunclassified

“…Foi detectado um aumento de 18.45% nos níveis de TNF-α nos animais do grupo βA quando comparado ao grupo Ctrl (1.01 ± 0.10 pg/mL, P < 0.05). Esta quantidade superior pode ser um reflexo das alterações inflamatórias ativas que caracterizam uma resposta à deposição de placas senis no cérebro dos animais através da infusão do peptídeo βA (ROJANATHAMMANEE et al, 2013;ESSA et al, 2015).…”

Section: Quantificação De Tnf-αunclassified

“…As pesquisas têm demonstrado o papel significativo da polpa de romã como um neuroprotetor na DA (HARTMAN et al, 2006;CHOI et al, 2011;ROJANATHAMMANEE et al, 2013;SUBASH et al, 2015). Os compostos fenólicos presentes nesta polpa, especialmente punicalagina (ROJANATHAMMANEE et al, 2013), seriam os responsáveis por este efeito neuroprotetor.…”

Section: Introductionunclassified

See 2 more Smart Citations