Long‐term absence of sensitization to mepivacaine as assessed by a diagnostic protocol including patch testing

Astarita, C.; Gargano, Domenico; Romano, Ciro; Cutajar, M.; Manguso, Francesco; Montanaro, Domenico; Napolitano, A.; Pezzuto, F.; Schiavo, M. Lo; Altucci, P; Abbate, Gianfranco

doi:10.1046/j.1365-2222.2001.01226.x

Cited by 16 publications

(8 citation statements)

References 31 publications

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“…Patient 8 had a negative patch test to parabens, whereas patient 5, who had an immediate reaction, was not tested. Other allergies, such as allergy to latex (5) or chlorhexidine (6, 7) should also be considered when appropriate.…”

Section: Reported Reactions In 48 Patients Figures In Brackets Are Nmentioning

confidence: 99%

Hypersensitivity to local anaesthetics

Jacobsen

Borch

Bindslev‐Jensen

2005

Allergy

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Section: Reported Reactions In 48 Patients Figures In Brackets Are Nmentioning

confidence: 99%

Hypersensitivity to local anaesthetics

Jacobsen

Borch

Bindslev‐Jensen

2005

Allergy

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“…The universality of latex products, and their presence in most medical and dental procedures, can lead to developing an allergy in almost everyone. None of the authors, however, has unequivocally commented on routinely performing allergic tests with latex proteins in patients suspected of allergy to local anaesthetics [4,15]. In type I mechanism, the symptoms are reported after 30 min from administering the drug, but they can also appear after a few hours.…”

Section: Discussionmentioning

confidence: 99%

The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners

Janas-Naze

Osica

2019

Int J Occup Med Environ Health

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Objectives: Local anesthetics are some of the most common drugs used in dentistry and about 6 million people daily around the world are subjected to their effect in procedures performed by a similar number of dentists who, in turn, are usually not aware of the fact of being allergic to this group of medications. Assuming that dentists are also patients, and that in their daily practice the contact with the allergen is very frequent, it is essential to assess the incidence of allergy to lidocaine in general dental practitioners. Material and Methods: The authors evaluated a group of 100 general dental practitioners in whom adverse reactions similar to anaphylaxis occurred after local anesthesia. The study included individuals who, in their thorough medical history, had experienced episodes of such reactions regarding the skin, airways, gastrointestinal tract and other areas. Results: The relations between type I hypersensitivity and certain symptoms, time from exposure to their appearance, as well as time from the last episode were investigated. Allergy to lidocaine was detected in 17 subjects-type I hypersensitivity was diagnosed in 13 cases (skin prick test-7; intradermic test-6) and 4 subjects had IgE-independent allergy (patch test). In the group where type I hypersensitivity was detected, urticaria, angioedema and rhinitis were indicated as inclusion criteria more often than among other subjects. According to the results, the occurrence of angioedema increased the risk of detection of type I hypersensitivity 68.8 times, and 1 year longer period from the last episode decreased this risk by circa 55%. Conclusions: The most important, from the clinical practice point of view, was to show the relation between the medical history indicating the anaphylactic nature of the lidocaine intolerance, and an allergy confirmed by skin tests.

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“…Allergic reactions after an intravenous injection of local anesthetic include contact dermatitis, which most often shows cutaneous signs such as erythema, pruritus, urticaria, or eczema that occur between 6 hours and 1 month after administration 5. True type I allergic reactions are reported in <1% of local anesthetic adverse drug reactions 6,7. In a large French survey reporting the incidence of anaphylaxis during anesthesia over a 2-year period, local anesthetics were involved in only one case (0.2%).…”

Section: Discussionmentioning

confidence: 99%

“…Contact dermatitis is the most commonly reported allergic reaction to several amide-type local anesthetics 5-7. Adverse local anesthetic-induced reactions through an IgE-mediated allergic mechanism (type I reaction) are still debated 5-8.…”

Section: Introductionmentioning

confidence: 99%

Bronchospasm and Anaphylactic Shock Following Lidocaine Aerosol Inhalation in a Patient with Butane Inhalation Lung Injury

Lee

Park

Yeo

et al. 2011

Allergy Asthma Immunol Res

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Allergic reactions to local anesthetics are very rare and represent <1% of all adverse local anesthetics reactions. A 54-year-old man was admitted to the hospital in the winter because of shortness of breath. The patient reportedly had an inhalation lung injury due to butane gas fuel. On the fifth day, he developed an asthmatic attack and anaphylactic shock immediately after lidocaine aerosol administration to prepare for bronchoscopy to confirm an acute inhalational lung injury diagnosis. Cardiopulmonary resuscitation was performed immediately after respiratory arrest, and the patient was admitted to the intensive care unit intubated and on a ventilator. He was extubated safely on the third post-cardiopulmonary resuscitation day. These observations suggest that aerosol lidocaine anesthesia may cause airway narrowing and anaphylactic shock. Practitioners should be aware of this potential complication. We report on this case with a brief review of the literature.

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Long‐term absence of sensitization to mepivacaine as assessed by a diagnostic protocol including patch testing

Cited by 16 publications

References 31 publications

Hypersensitivity to local anaesthetics

Hypersensitivity to local anaesthetics

The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners

Bronchospasm and Anaphylactic Shock Following Lidocaine Aerosol Inhalation in a Patient with Butane Inhalation Lung Injury

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