Long-term Administration of Cannabis sativa Impairs Learning and Memory in CD1 Mice

Abstract

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Effect of n-butanol extract of Cannabis sativa L. extract on the cerebral cortex of adult Wistar rats

“…All these changes observed could be a result of the presence of the psychoactive compounds in the plants. Okon et al (2014) also reported a similar result to this study, the dose of 10 and 20 mg/kg body weight of ethanol extract of C. sativa L. for 28 days; they observed decrease locomotor activity compared with the control that received normal saline. Therefore, since a lower dose (10 and 20 mg/kg) of the extract is liable of causing motor impairment it is no doubt that 250 and 500 mg/kg of n-butanol extract of C. sativa L. would cause motor deficit as seen in the foot fault scoring.…”

Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice

“…The results of users' cannabis range from euphoric, anxious and increased risk of depression to paranoia, anxiety and elevated ( Kardash et al, 2019 ). It has also been confirmed that cannabis sativa is one of the causes of personal schizophrenia, and that taking cannabis sativa in the long term reduces motor activity and exploration and increases fear ( Okon et al, 2014 ), or increase the causes of anxiety. Some research shows that some male genital parameters such as testosterone secretion, sperm production, motility and vitality have fallen and that the production of LH has fallen.…”

“…Pot, weed, grass, ganja, and skunk are some of the terms commonly used to describe the dried leaves of the Cannabis plant ( Okon et al, 2014 ). Cannabis ( Table 1 ) is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax, found in warm and tropical regions.…”

“…Cannabis ( Table 1 ) is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax, found in warm and tropical regions. It is 5 m long with a resin ring, and the leaves are 10 cm long and 1.5 cm wide ( Okon et al, 2014 , Alagbonsi and Olayaki, 2016 ). Cannabis is the world's most common illicit substance.…”

Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca L. (Musaceae)

“…Arm entry was only defined when an animal (the mouse mass center) was at least 3 cm on an arm to differentiate entries from stretched attend postures into the arms. 14 …”