Long term administration of gentamicin affects hemato-biochemical parameters and liver architecture of Swiss albino mice

Jannat, Nure; Amin, Tanjina; Sultana, Nasrin; Jahan, Mir Rubayet; Islam,

doi:10.5455/jabet.2018.d6

Cited by 6 publications

(4 citation statements)

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“…Our findings are in contrary to the results of Dinev et al, (2005) who reported that there is tendency toward a decrease of TEC, haemoglobin concentration and haematocrit percentage after 5 days intramuscular administration with amikacin (10 mg/kg bwt) in healthy female goats. Contrary result also observed by Jannat et al, (2018), who reported significantly reduced the TEC, TLC and Hb after gentamicin administration. Another findings were reported by Lijana and Williams (1986) after a long term exposure of aminoglycosides in high dose affects the haemopoietic cells in the bone marrow and decrease erythrocyte production.…”

Section: Resultscontrasting

confidence: 79%

Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin

Kumar¹,

Singh²,

Shakya³

et al. 2021

Int.J.Curr.Microbiol.App.Sci

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Section: Resultscontrasting

confidence: 79%

Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin

Kumar¹,

Singh²,

Shakya³

et al. 2021

Int.J.Curr.Microbiol.App.Sci

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“…Hepar adalah kelenjar terbesar di tubuh dan memainkan fungsi paling penting tidak hanya dalam penyimpanan dan pelepasan nutrisi tetapi juga dalam netralisasi dan eliminasi berbagai zat beracun. Ginjal merupakan organ kadang menerima dampak yang tidak dinginkan akibat dari penggunaan obat, seperti toksisitas terhadap nefron (Jannat et al, 2018). Organofosfat dapat meningkatkan stres oksidatif, pembentukan ROS, menginduksi cedera seluler dan nekrosis melalui penurunan tingkat aktivitas enzim antioksidan non-enzimatik dan enzimatik yang mengarah pada produksi berlebihan ROS, sehingga dapat menyebabkan kerusakan pada lipid membran, protein dan asam nukleat, yang menyebabkan toksisitas, disfungsi, dan cedera pada hepar (Galaly et al, 2014;Almohawes, 2017;Rashid dan Khan, 2017).…”

Section: Pendahuluanunclassified

The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure

et al. 2023

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This study aimed to determine the effect of black cumin extract (Nigella sativa) on the histopathological of the liver and kidneys in albino rats exposed to organophosphates. This study used 20 male mice divided into five treatment groups, i.e. (K-) without organophosphate and black cumin, (K+) induced by organophosphate 40 mg/kg BW, treatment group induced by organophosphate 40 mg/kg BW and black cumin extract as therapy (P1 ) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. Organophosphate administration for eight weeks and black seed extract therapy was given for three weeks then the mice were euthanized, the liver and kidney organs were taken for histopathological observation using Haematoxylin-Eosin (HE). Data were analyzed using OneWay ANOVA test followed by Tukey test. The results showed that there were significant differences between the treatment groups for liver and kidney damage (p<0,05). Hepatic degeneration and necrosis in the P2 and P3 groups differed from K+ with an average of 2,24±0,9, in the kidneys with an average of 2,52±0,8. It can be concluded that black cumin extract has a significant effect on improving the liver and kidneys in groups P3 (600 mg/kgBW).

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“…Following proper fixation, samples were processed for histopathological examination. For histopathology, the Hematoxylin and Eosin staining protocol was performed according to Jannat et al (2018).…”

Section: Gross and Histopathological Studiesmentioning

confidence: 99%

Effects of Dietary Supplementation With Soybean And Canola Oil on Lipid Profiles and Heart in Swiss Albino Mice

Sarif

Akter

Haque

et al. 2022

Ann. Bangladesh Agric.

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Soybean and canola oil are two of the most widely used cooking oils on the planet. The experiment was conducted to study the dose dependent toxicity of dietary supplementation of soybean and canola oil on heart of Swiss albino mice. In the study, 30 male Swiss albino mice aged 6 weeks were randomly assigned to one of five equivalent groups: Group A was considered as control by feeding rat pellet only, group B1 and B2 were supplemented with 25 and 35 ml soybean oil/kg pellet and group C1 and C2 were provided with 25 and 35 ml canola oil/kg pellet, respectively for 60 days, adopting established research procedure. After conducting the experimental period, blood and organ (heart) samples were collected from control and oil supplemented mice through deep anesthesia. The biochemical study of blood revealed that maximum total cholesterol, triglycerides and high density lipoprotein values (153.85 ± 0.44, 88.82 ± 0.37 and 105.50 ± 0.33 mg/dl) were found statistically significant (P<0.05) in soybean oil supplemented group (B2) as compared to other groups (B1, C2, C1 and A). Gross study revealed that highest mean weight of heart (0.41 ± 0.01 g) was recorded in soybean oil supplemented group (B2) significantly (P<0.05) in comparison to other experimental groups B1, C2, C1 and A. Histopathological study revealed that marked lymphocytic infiltration was found in the ventricular wall of the heart of high dose supplemented groups. So, it may conclude that dietary supplementation of soybean and canola oil have adverse effects on blood lipid profiles and heart of mice.Ann. Bangladesh Agric. (2021) 25 (2) : 87-95

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Long term administration of gentamicin affects hemato-biochemical parameters and liver architecture of Swiss albino mice

Cited by 6 publications

References 0 publications

Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin

Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin

The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure

Effects of Dietary Supplementation With Soybean And Canola Oil on Lipid Profiles and Heart in Swiss Albino Mice

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