Long-term administration of progesterone to the female beagle dog

Capel-Edwards, K.; Hall, D.E.; Fellowes, K. P.; Vallançe, D. K.; Davies, Michael J.; Lamb, D. R.; Robertson, W. B.

doi:10.1016/0041-008x(73)90054-9

Cited by 36 publications

(10 citation statements)

References 10 publications

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“…Similar changes have been produced in the female dog by using naturally occurring hormone progesterone [3,7,8, 201. The causal relationship of cystic glandular hyperplasia to the synthetic progestogen, medroxyprogesterone acetate, is well documented [l, 21.…”

Section: Absrructmentioning

confidence: 77%

“…The dog is sensitive to progesterone derivatives such as chlormadinone acetate and much less sensitive to 19-nortestosterone derivatives such as norethindrone [12]. Progesterone caused many of the same changes [3] as megestrol acetate and chlormadinone acetate.…”

Section: Discussionmentioning

confidence: 89%

“…The causal relationship of cystic glandular hyperplasia to the synthetic progestogen, medroxyprogesterone acetate, is well documented [l, 21. Clinical descriptions of mammary development and secretion are occasionally included in these reports [3,4], but most are for the uterus with no reference to the histologic changes in the other genital organs. …”

mentioning

confidence: 99%

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Progestogen-Related Gross and Microscopic Changes in Female Beagles

Nelson

Kelly

1976

Vet Pathol

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Absrruct.Long-term studies of megestrol acetate and chlormadinone acetate in 100 female dogs are in progress. Doses of zero, one, 10 and 25 times the expected human dose of megestrol acetate and 25 times the expected human dose of chlormadinone acetate (on a milligram per kilogram body weight basis) are being given daily. During the first 4 years, eight dogs from each of the five groups were killed. The principal gross findings included enlarged uteri with mucoid material in the lumina, mammary development in dogs given middle and high doses of megestrol acetate and chlormadinone acetate, and thickened gallbladder walls in dogs given high doses of each. Histologic evaluation showed inhibition of ovulation for progestogen-treated dogs and suppression of ovarian follicular development with the high doses. Cystic endometrial hyperplasia was slight in the low-dose dogs and moderate to severe in most of the high-dose dogs; a few also had ulcerative endometritis and pyometra. The mammary glands of dogs given the middle and high doses produced lobules, acini, and secretion exceeding natural metestrus. Slight to marked cystic mucinous hyperplasia occurred in the gallbladders of most dogs given the high doses. Two high-dose megestrol dogs had clinical signs and microscopic pancreatic, renal, and ocular changes indicative of diabetes mellitus.Uterine cystic glandular hyperplasia and pyometra have been known to be related to endocrine imbalances in female dogs for many years [5,6,23]. Similar changes have been produced in the female dog by using naturally occurring hormone progesterone [3,7,8, 201. The causal relationship of cystic glandular hyperplasia to the synthetic progestogen, medroxyprogesterone acetate, is well documented [l, 21. Clinical descriptions of mammary development and secretion are occasionally included in these reports [3,4], but most are for the uterus with no reference to the histologic changes in the other genital organs.

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Section: Absrructmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 89%

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Progestogen-Related Gross and Microscopic Changes in Female Beagles

Nelson

Kelly

1976

Vet Pathol

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“…Production of FSH and LH hormones by the anterior pituitary gland is inhibited by progesterone, thereby preventing follicular growth, maturation, secretion, and ovulation 1 . Larger doses or chronic oral administration of progestogens have been reported to produce various pathogenic effects in addition to estrus prevention in female dogs 2,3 . The pathologic changes include mammary development with subsequent mammary tumor 4 , cystic hyperplasia of endometrium with subsequent pyometra 2 , and atrophy of adrenal cortex 5 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Immunohistochemical Studies in Female Beagle Dogs during Four Years Treatment with Implantation of Chlormadinone Acetate(CMA).

et al. 2001

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Abstract:The histopathological changes related to chlormadinone acetate (CMA) implantation were examined using female beagle dogs given 10 mg/kg for four years. Estrus was completely inhibited in the CMA-implanted animals. In contrast, all control animals showed sign of estrus during the experiment, with periods of anestrus of normal duration. Histopathlogically, uterine sections from the CMA-implanted animals showed cystic glandular hyperplasia, but no histologic evidence of endometritis, myometritis, and pyometra was found. In the ovaries of the CMA-implanted animals, developing ovarian follicles were observed but no mature follicles were noted in addition to an absence of corpus luteum. No remarkable changes were observed in liver, adrenal, mammary gland, gallbladder, and implanted site. Furthermore, the intensity of staining and number of adrenocorticotropic hormone (ACTH)-and luteininzing hormone (LH)-positive cells in the pituitary sections of CMA-implanted animals were not different from the control animals. It was concluded, therefore, that subcutaneous implantation of CMA (10 mg/kg) is nearly equivalent to the minimal ovulation-suppressing dose. (J Toxicol Pathol 2001; 14: 9-12)

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“…Experimental studies using beagles treated with anticonceptional progestins show that bitches treated with moderate or high doses are especially prone to develop hyperplastic, benign neoplastic or even malignant lesions (4,8,17,20,22,31,32,39). Even relatively low doses of progestins seem to stimulate development of hyperplasias and benign tumours in the canine mammary gland (18).…”

mentioning

confidence: 99%

Canine mammary tumours: Protective effect of late ovariectomy and stimulating effect of progestins

Misdorp

1988

Veterinary Quarterly

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Long-term administration of progesterone to the female beagle dog

Cited by 36 publications

References 10 publications

Progestogen-Related Gross and Microscopic Changes in Female Beagles

Progestogen-Related Gross and Microscopic Changes in Female Beagles

Histopathological and Immunohistochemical Studies in Female Beagle Dogs during Four Years Treatment with Implantation of Chlormadinone Acetate(CMA).

Canine mammary tumours: Protective effect of late ovariectomy and stimulating effect of progestins

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