Offshore structure heavy lifts, such as drilling platforms, large port machinery, etc., are currently mostly transported by semi-submersible ships over long distances. Due to the effect of the marine environment, the heavy structures carried by ships need to be securely fastened to the carrying ships. The rolling of structures caused by the movement of ships during transportation is an important factor affecting their lashing and reinforcement. At this stage, there are two commonly used inertial force calculation methods. The paper simulates and calculates the motion and load response of the ship during the navigation process based on the joint distribution frequency of the significant wave height and period of two typical waves in the sea area. During the numerical simulation of sailing, the roll response of the ship under different waves is calculated. In order to reduce the roll amplitude, it is recommended that the ship keep the top wave or the inclined top wave within 40° of the unilateral wave direction from 180° to 140° when sailing in the middle and high latitude harsh sea areas. Expanded to 60° range from 180° to 120°.