Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). The associations of alcohol intake with DR risk have demonstrated contradictory results. Relevant studieswere identified by searching electronic databases (Medline, EMBASE and Web of Science) until May 2016. We identified a total of 12,875 DR cases among 37,285 participants in 15 observational studies. The pooled estimation of all the included observational studies was 0.91 (95% CI, 0.79 to 1.06) in a random-effect model. Analyses stratified by study design showed no significant association between alcohol intake and DR incidence in cohort, case control or cross-sectional studies. In the subgroup analyses, neither beer nor spirits intake were associated with DR risk. Furthermore, it was interesting to find that protective effects were detected in the wine (OR = 0.77, 95% CI = 0.64 to 0.92) and sherry (OR = 0.22, 95% CI = 0.05 to 0.95) groups. In conclusion, this current meta-analysis demonstrated that alcohol intake was not associated with risk of DR. Subgroup analysis by alcoholic beverage types showed that wine consumption would reduce the incidence of DR. In the future, more large-scale prospective studies with detailed alcohol subtypes and contents are still warranted to clarify the association.Diabetes mellitus (DM) is now regarded as one of the most challenging public health problems worldwide 1 . Both the economic burden and loss of health caused by complications of DM indicate the importance of primary prevention and early intervention in the management of DM 2, 3 . Diabetic retinopathy (DR) is a common microvascular complication of DM and a major preventable cause of visual impairment in the working-age population 4 . Accordingly, early detection of DR in the DM population is crucial. The mechanisms of DR development and progression are still not fully understood 5,6 . Previous epidemiological studies indicated that longer DM duration, older age, aging and cardiovascular events were risk factors for DR incidence 7,8 .Alcohol intake is reported to be a risk factor for several kinds of diseases, including cancers, gastrointestinal diseases, respiratory disorders and infections [9][10][11] . A quantitative review of 26 epidemiological studies reported an inverse association between alcohol intake and risk of type 2 DM (T2DM) in a non-linear dose-response manner. It was found that light and moderate alcohol consumption was associated with a lower risk of T2DM, whereas heavy alcohol consumption demonstrated no protective effect against T2DM risk 12 . Furthermore, in an advanced study, specific types of alcoholic beverage consumption demonstrated modified influences on T2DM risk. In a meta-analysis of 13 prospective studies, compared with beer or spirits, wine was associated with a more significant inverse risk of DM 13 .In previous studies, the associations of alcohol intake with DR risk demonstrated contradictory results. Alcohol intake, which was regarded as an unhealthy lifestyle behavior, was previously regarded a...