Long‐term antibiotic use for the treatment of hidradenitis suppurativa consistent with guideline recommendations

Kitts, Sarah; Govea, R.; Maczuga, Steve; Kirby, Joslyn

doi:10.1111/ced.14512

Cited by 10 publications

(8 citation statements)

References 6 publications

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“…Antibiotics, both topical and systemic, are often used as a first line therapy in treating HS. Systemic tetracycline therapy is amongst the most prescribed therapy along with clindamycin, rifampin, and dapsone ( 166 ). These classes of antibiotics have well documented anti-inflammatory action that, along with their antibacterial activity, is crucial in treating HS.…”

Section: Treatment Strategiesmentioning

confidence: 99%

Innate immunity and microbial dysbiosis in hidradenitis suppurativa – vicious cycle of chronic inflammation

et al. 2022

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Hidradenitis Suppurativa (HS) is a chronic multifactorial inflammatory skin disease with incompletely understood mechanisms of disease pathology. HS is characterized by aberrant activation of the innate immune system, resulting in activation of pathways that aim to protect against pathogenic microorganisms, and also contribute to failure to resolve inflammation. Imbalance in innate immunity is evident in deregulation of host antimicrobial peptides (AMPs) and the complement system associated with the microbiome dysbiosis. The pathology is further complicated by ability of pathogens associated with HS to overcome host immune response. Potential roles of major AMPs, cathelicidin, defensins, dermcidin, S100 proteins, RNAse 7 and complement proteins are discussed. Dysregulated expression pattern of innate immunity components in conjunction with bacterial component of the disease warrants consideration of novel treatment approaches targeting both host immunity and pathogenic microbiome in HS.

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Section: Treatment Strategiesmentioning

confidence: 99%

Innate immunity and microbial dysbiosis in hidradenitis suppurativa – vicious cycle of chronic inflammation

et al. 2022

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“…Patients with refractory disease under topical therapies or with severe inflammation activity are potential candidates for systemic antibiotic therapy ( Table 1 ). A current study assessed the duration of antibiotic treatments in HS patients and showed that in the majority of oral antibiotic courses the duration of treatment was less than 12 weeks [ 68 ].…”

Section: Treatmentmentioning

confidence: 99%

Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

Ocker

Rached

Seifert

et al. 2022

JCM

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients’ quality of life and is associated with a variety of comorbidities. Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available. However, especially in moderate-to-severe HS, there is an urgent need for new treatment approaches. In recent years, increased research has led to the identification of new potential therapeutic targets. This review aims to give a comprehensive and practical overview of current treatment options for HS. Furthermore, the clinically most advanced novel treatment approaches will be discussed.

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“…Antimicrobials are a core treatment modality, where they are used primarily for their immunomodulatory and anti-inflammatory properties. Patients are commonly prescribed prolonged and repeated courses of single and combination antibiotics [1, 7, 8]. Initial treatment is often with tetracyclines or rifampicin and clindamycin.…”

Section: Introductionmentioning

confidence: 99%

Microbial Isolates and Association with Disease Severity and Quality of Life in Individuals with Hidradenitis Suppurativa: An Observational Study

Bailey

Buckingham

Maxwell-Scott

et al. 2022

Skin Appendage Disord

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Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by recurrent nodules, abscesses, and sinus tracts, resulting in scarring. Patients suffer significantly impacted quality of life (QoL), manifested by anxiety and depression. We describe microbial isolates identified from active sites in adults with HS, and explore associations between organisms isolated, disease severity, and QoL. Methods: Observational study over 2 years. Assessment was made of disease severity using the Hurley staging score and of QoL scores, and subjective assessment. Wound swab samples were obtained from sites of active disease. Descriptive summary statistics and tests of significance were used to analyse the data. Results: Two hundred and twelve patients participated, resulting in 352 episodes, and 501 lesion swab samples. 54% were female and 59% were obese, median age of 37 years. A lower proportion of Gram-negative organisms and more staphylococcal and streptococcal organisms were isolated from sites of disease in individuals with stage 3 disease compared to those with stage 1–2 disease (p = 0.001). We found no association between microbial isolation and QoL. Discussion/Conclusions: Hurley stage 3 disease is associated with more infected lesions than Hurley stage 1–2 disease, but the QoL experienced by patients with HS is determined by factors other than infection.

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Long‐term antibiotic use for the treatment of hidradenitis suppurativa consistent with guideline recommendations

Cited by 10 publications

References 6 publications

Innate immunity and microbial dysbiosis in hidradenitis suppurativa – vicious cycle of chronic inflammation

Innate immunity and microbial dysbiosis in hidradenitis suppurativa – vicious cycle of chronic inflammation

Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

Microbial Isolates and Association with Disease Severity and Quality of Life in Individuals with Hidradenitis Suppurativa: An Observational Study

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