Long-term antibiotics for preventing recurrent urinary tract infection in children

Abstract

Long-term antibiotics for preventing recurrent urinary tract infection in children.

Reversible lung fibrosis in a 6-year-old girl after long term nitrofurantoin treatment

“…Nitrofurantoin is an antibiotic medicament often used in the treatment of recurrent urinary tract infections as the urinary excretion rate is high. Recent studies have questioned the efficacy of antibiotics in the prevention of recurrent urinary tract infections and secondary renal injury in children [ 7 ]. In a recent paper in the Lancet, the authors concluded that “a trial using antimicrobial prophylaxis in children with several recurrent episodes of acute pyelonephritis is warranted” [ 8 ].…”

Management of paediatric recurrent urinary tract infections and challenges in special patient populations

“…1 Up to 30% of these children will experience at least one recurrence within 6-12 months. 2,3 While 3-15% of children with a first UTI will show renal parenchymal scarring within 1-2 years of their first UTI, [4][5][6][7] the risk of acquired chronic kidney disease remains low. 5,8 An rUTI can be defined as a repeated presentation with separate episodes of cystitis, pyelonephritis or urosepsis.…”

Antibiotic Stewardship (ABS) in der stationären Kinder- und Jugendmedizin

“…Durch eine gezielte Anamnese kann die Wahrscheinlichkeit, dass es sich um einen HWI durch Erreger mit speziellen Resistenzen handelt, deutlich erhöht werden. Meist handelt es sich dabei um Kinder mit angeborenen Fehlbildungen der Harnwege unter einer antibiotischen Prophylaxe oder um Kinder mit wiederholter Antibiotikaexposition und Krankenhausaufenthalten in den letzten Monaten [22].…”