Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease

Shechter, Michael; Issachar, Assaf; Marai, Ibrahim; Koren‐Morag, Nira; Freinark, Dov; Shahar, Yael; Shechter, Alon; Feinberg, Micha S.

doi:10.1016/j.ijcard.2008.01.021

Cited by 200 publications

(76 citation statements)

References 33 publications

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“…FMD and HRV measurements may thus be more sensitive in detecting early cardiovascular alterations. A previous study has also proposed that attenuated FMD may predict cardiovascular dysfunction (63). Both the FMD and HRV data suggest that shift workers exert The standard deviation of the normal-to normal interval between QRS complexes (SDNN) and (B) low frequency/high frequency (LF/HF) ratio (mean and standard error of the mean) among non-shift (•) and shift workers (○) 0.25, 4.25, 11.5, 12.5, and 13.5 hours after habitual wake time following baseline sleep, total sleep deprivation and recovery sleep.…”

Section: Discussionmentioning

confidence: 96%

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers

Wehrens¹,

Hampton²,

Skene³

2011

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 96%

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers

Wehrens¹,

Hampton²,

Skene³

2011

Scand J Work Environ Health

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“…Endothelial dysfunction is common in CKD and has been shown to predict CVD prospectively in several groups, including healthy individuals,32, 33 individuals with peripheral vascular disease,34 and CKD 35. To explore this hypothesis we recruited healthy control subjects and patients with stage III and IV CKD.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Jalal

Renner

Laskowski

et al. 2018

JAHA

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BackgroundEndothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD.Methods and ResultsWe analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow–mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio. Endothelial microparticles were characterized via proteomic analysis and compared between study groups. Complement fragment Ba was significantly increased in CKD and post–kidney transplant CKD. Plasma Ba levels correlated significantly with lower brachial artery flow–mediated dilation, lower Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and higher urinary albumin/creatinine ratio. Factor D levels were significantly higher in the plasma microparticles of patients with CKD versus healthy controls. Plasma microparticles isolated from patients with CKD and containing factor D activated the alternative pathway in vitro.ConclusionThe alternative complement pathway is activated in CKD and correlates with endothelial dysfunction and markers of CKD. Future studies are needed to evaluate whether endothelial microparticles with increased factor D play a pathologic role in CKD‐associated vascular disease.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02230202.

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“…Chronically reduced NO bioavailability could play a mechanistic role in the progression of cardiovascular disease (CVD) (2). In fact, impaired FMD is now recognised as an independent risk factor for the development of CVD (4)(5). Several cardiovascular risk factors including hypertension (6) and overweight/obesity (7) are associated with impaired FMD, which may reflect structural and functional changes to the endothelium (8).…”

Section: Introductionmentioning

confidence: 99%

“…However, it is not known which specific polyphenolic compounds present in these foods are responsible for this beneficial effect. Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenol predominately found in red wine and grapes that has attracted much interest due to its cardioprotective potential shown in vivo (14)(15)(16). Resveratrol exists in cis-and trans-isomeric forms, but only trans-isomer is mainly present in wine (17), which can be found at highest concentration in grape skin in ranges between 50 and 400µg/g of fresh weight (18).…”

Section: Introductionmentioning

confidence: 99%

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

Wong

Howe

Buckley

et al. 2011

Nutrition, Metabolism and Cardiovascular Diseases

255

218

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243Text 2129 Number of references 31 Number of figures 3Number of tables 1 and on FMD (P<0.01), which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270mg resveratrol. FMD was also linearly related to log10 plasma resveratrol concentration (P<0.01).(3) Conclusion-Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.4

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Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease

Cited by 200 publications

References 33 publications

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

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