Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011

Deygas, Floriane; Amadou, Amina; Coudon, Thomas; Grassot, Lény; Couvidat, Florian; Bessagnet, Bertrand; Faure, Élodie; Salizzoni, Pietro; Gulliver, John; Caudeville, Julien; Severi, Gianluca; Mancini, Francesca Romana; Leffondré, Karen; Fervers, Béatrice; Praud, Delphine

doi:10.1016/j.envres.2021.110743

Cited by 15 publications

(11 citation statements)

References 66 publications

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“…Geocoding was performed by a trained technician blinded to the casecontrol status of the participants, using a validated method (Faure et al, 2017). Management of missing and incomplete addresses has been described previously (Deygas et al, 2021). In brief, women who had at least one missing address in questionnaires, or at least one address outside the continental mainland France, were excluded, as well as their matched cases or controls.…”

Section: Methodsmentioning

confidence: 99%

“…Among the 98,995 women included in the E3N cohort study, 6,298 incident breast cancer diagnoses were identi ed between 1990 and 2011 (Figure S4 in Supplementary Material (Deygas et al, 2021). After excluding 19 cases of Paget disease and phyllodes tumors, 3 cases with missing data on matching factors, and 1,054 cases or controls with missing data on addresses or addresses outside metropolitan France, the XENAIR case-control study included 5,222 cases and 5,222 matched controls (Deygas et al, 2021). For the present study, we further excluded 331 women with follow-up shorter than one year, leaving 5,058 cases and 5,059 controls for the trajectory analysis, and 5,058 case-control pairs for the conditional logistic regression analysis.…”

Section: Cases and Controls Selection And Characteristicsmentioning

confidence: 99%

“…Air pollution is a complex mixture of multiple pollutants including compounds with endocrinedisrupting properties such a polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) (Brody et al, 2007). Increased risks for breast cancer associated with exposure to PCBs, and benzo[a]pyrene (BaP) the most well-known PAH, have been reported (Amadou et al, 2021;Deygas et al, 2021;Lauby-Secretan et al, 2013;Liu et al, 2023). However, to date, the epidemiologic evidence on the effect of environmental exposure to these agents has been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…A positive correlation between PCB153 and total PCBs has been observed in several studies (Bachelet et al, 2011;Demers et al, 2000). In the XENAIR case-control study nested with the French prospective E3N cohort (Amadou et al, 2020b), we assessed air pollutant exposure at the residential addresses up to 22 years prior to breast cancer diagnosis and found a positive association with long term exposure to airborne PCB153 (Deygas et al, 2021). For each one standard deviation (SD, 55 pg/m3) increase of the cumulative of airborne PCB153 concentration levels, the adjusted odds ratio (OR) was 1.19 (95% con dence interval (CI): 1.08-1.31) (Deygas et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer

Desnavailles,

Praud,

Provost

et al. 2024

Preprint

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Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP), are of particular concern due to endocrine-disrupting properties, and accumulation in various environmental matrices and human adipose tissue owing to poor biodegradability. Objective: To identify distinct lifetime trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk. Methods: We used data from the XENAIR case-control study, nested within the ongoing prospective French E3N cohort which enrolled 98,995 women aged 40-65 years in 1990-1991. Cases were incident cases of primary invasive breast cancer diagnosed from cohort entry to 2011. Controls were randomly selected by incidence density sampling, and individually matched to cases on delay since cohort entry, and date, age, department of residence, and menopausal status at cohort entry. Annual mean outdoor PCB153 and BaP concentrations at residential addresses from 1990 to 2011 were estimated using the CHIMERE chemistry-transport model. Latent class mixed models were used to identify profiles of exposure trajectories from cohort entry to the index date, and conditional logistic regression to estimate their association with the odds of breast cancer. Results: 5058 cases and 5059 controls contributed to the analysis. Five profiles of trajectories of PCB153 exposure were identified. The class with the highest PCB153 concentrations had a 69% increased odds of breast cancer compared to the class with the lowest concentrations (95% CI 1.08, 2.64), after adjustment for education and matching factors. We found no association between identified BaP trajectories and breast cancer. Conclusions: Our results support an association between long term exposure to PCB153 and the risk of breast cancer, and encourage further studies to account for lifetime exposure to persistent organic pollutants.

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Section: Methodsmentioning

confidence: 99%

Section: Cases and Controls Selection And Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer

Desnavailles,

Praud,

Provost

et al. 2024

Preprint

Self Cite

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“…Though, these results need further confirmation. Another cohort study has found a linear positive correlation between long term environmental exposure to Polychlorinated biphenyls (PCB 153), an air pollutant with an estrogenic action, and increased risk of estrogen receptor positive breast cancer in women ( 78 ).…”

Section: Health Effects Of Climate Change-induced Environmental Expos...mentioning

confidence: 99%

Climate change, human health, and the exposome: Utilizing OMIC technologies to navigate an era of uncertainty

Abdelzaher

Tawfik

Nour

et al. 2022

Front. Public Health

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Climate change is an anthropogenic phenomenon that is alarming scientists and non-scientists alike. The emission of greenhouse gases is causing the temperature of the earth to rise and this increase is accompanied by a multitude of climate change-induced environmental exposures with potential health impacts. Tracking human exposure has been a major research interest of scientists worldwide. This has led to the development of exposome studies that examine internal and external individual exposures over their lifetime and correlate them to health. The monitoring of health has also benefited from significant technological advances in the field of “omics” technologies that analyze physiological changes on the nucleic acid, protein, and metabolism levels, among others. In this review, we discuss various climate change-induced environmental exposures and their potential health implications. We also highlight the potential integration of the technological advancements in the fields of exposome tracking, climate monitoring, and omics technologies shedding light on important questions that need to be answered.

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Association between long-term ambient air pollution exposure and the risk of breast cancer: a systematic review and meta-analysis

et al. 2021

Environ Sci Pollut Res

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Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011

Cited by 15 publications

References 66 publications

Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer

Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer

Climate change, human health, and the exposome: Utilizing OMIC technologies to navigate an era of uncertainty

Association between long-term ambient air pollution exposure and the risk of breast cancer: a systematic review and meta-analysis

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