Long-term benefits and repeated treatment cycles of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee

Kolarz, G; Kotz, R.; Hochmayer, Ingrid

doi:10.1053/sarh.2002.50013

Cited by 58 publications

(36 citation statements)

References 9 publications

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“…Meanwhile, in the case of profound cartilage damage, it is important to consider possible microfracturing. Another method of reducing pain is the application of a hyaluronic acid compound [46][47][48]. Correspondingly, obtaining a steady state of cartilage morphology by means of the intake of reconstructing substances, such as chondroitin sulphate in the form of tablets is reasonable.…”

Section: Discussionmentioning

confidence: 99%

Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents

et al. 2011

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“…Several studies have confirmed that viscosupplementation (VS) by intra-articular injections of hyaluronic acid (HA) has useful therapeutic effects in the knee in selected patients (9)(10)(11)(12) and has been recommended by expert panels as an effective symptomatic slow acting treatment (13).…”

Section: Introductionmentioning

confidence: 99%

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Abate¹,

Pelotti²,

Amicis³

et al. 2008

Upsala Journal of Medical Sciences

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Background: Viscosupplementation (VS) with hyaluronic acid (HA) is largely used for knee osteoarthritis therapy, but the evidences for its usefulness in hip osteoarthritis (OA) are limited. Methods: In this review, an extensive search of published trials on VS in hip OA was performed. From the selected papers the following data were extracted: sample size, inclusion / exclusion criteria, treatment procedures, evaluation methods, follow-up duration and clinical outcomes. Results: The level of evidence was low in quite all the trials (no placebo controlled groups). A reduction of pain and an improvement of function after 3 months, persistent in the long term (12 -18 months), was observed. Patients with mild morphological alterations responded better to therapy. Side effects were negligible, and were limited to pain and a sensation of heaviness in the injection site. No clear differences among Low (LMW) and High Molecular Weight (HMW) HA preparations were found in the clinical outcomes. However, for HMW-HA preparations, a lower number of injections was, in general, necessary in order to reach the therapeutic effect. Conclusions: Despite the initial promising results, some questions still remain open : 1) the characteristics of responders must be more precisely defined; 2) the treatment schedules, at present mainly based on the individual clinical experience, need a proper and accepted standardization. Finally, larger and placebo controlled trials are necessary to confirm the efficacy of VS in hip OA.

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“…In particolare, l'uso di acido di acido ialuronico cross-linked (Hylan GF-20) si è dimostrato particolarmente efficace, in virtù delle sue proprietà di elevata viscoelasticità (11). Un ciclo di 3 iniezioni di Hylan GF-20 risulta efficace per alleviare i sintomi per oltre 12 mesi in pazienti con gonartrosi (12); in letteratura si rinvengono numerose pubblicazioni inerenti il dosaggio, la tollerabilità e l'efficacia a lungo termine dei prodotti dell'acido ialuronico nel trattamento dell'artrosi di ginocchio (9)(10)(11)(12)(13)(14)(15)(17)(18)(19)(20). Al contrario, si riscontrano scarsi dati circa la viscosupplementazione dell'anca artrosica (16,21,23,31,37).…”

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18 month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis

Migliore¹,

Tormenta²,

Massafra³

et al. 2011

Reumatismo

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rioramento della cartilagine e del sottostante osso subcondrale; tali fenomeni si riflettono, clinicamente, nel graduale sviluppo di dolore e nella riduzione della funzione articolare (1). La localizzazione coxofemorale dell'artrosi risulta particolarmente frequente, con un'incidenza media variabile a seconda delle casistiche da 88 a 47,3 casi per 100.000 abitanti (2, 3). Il sollievo dal dolore è, tuttora, un obiettivo primario nel trattamento dei pazienti affetti da coxartrosi. Analgesici, FANS, COX-2 inibitori sono diffusamente utilizzati e considerati, pertanto, un trattamento standard nella gestione dell'OA a carico del ginocchio e dell'anca. Sfortunatamente, molti pazienti sviluppano seri effetti collaterali, anche fatali, indotti dai FANS (4-6), prevalente- INTRODUZIONE L'artrosi (OA) è una malattia caratterizzata da una serie di modificazioni biochimiche, molecolari, biomeccaniche e morfologiche, a carico della matrice extracellulare e della componente cellulare, che inducono essenzialmente un dete- Reumatismo, 2006; 58(1):39-49 SUMMARY Objective: To evaluate the efficacy and the tolerability of viscosupplementation (VS) with hyaluronic acid (Hylan G-F 20) in a cohort of 36 patients affected by hip osteoarthritis through a 18 months follow-up. Methods: Viscosupplementation was performed with an anteriorsagittal approach, under ultrasound guidance. 36 patients were administered hyaluronic acid intraarticularly in the hip, with a unique injection of Hylan G-F20, which could be repeated after at least 3 months. Treatment efficacy was assessed by functional index WOMAC

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Long-term benefits and repeated treatment cycles of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee

Cited by 58 publications

References 9 publications

Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents

Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

18 month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis

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