Long-term Benzodiazepine Administration Blunts Growth Hormone Response to Diazepam

Shur, Eric

doi:10.1001/archpsyc.1983.01790090067010

Cited by 13 publications

(1 citation statement)

References 25 publications

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“…The benzodiazepines are the most widely used hypnotics in the adult population, but their acceptance by and success in geriatrics has been less dra matic, probably due to the severe side effects they involve [ Viukari et al, 1978;Greenblatl et al, 1978]. Tolerance to the sedative effects of benzodiazepines in clinical prac tice is well documented [Owen and Tyrer, 1983;Shur et al, 1983]. Consequently, alternative hypnotics are needed, and their intermittent or sequential use may be necessary to ensure efficacy.…”

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confidence: 99%

Diazepam, Promethazine and Propiomazine as Hypnotics in Elderly Inpatients

Viukari¹,

Miettinen²

1984

Neuropsychobiology

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Diazepam 5 mg, promethazine 25 mg, propiomazine 25 mg, and placebo as sleeping aids were studied in 40 elderly inpatients. The drugs were administered in a random order, double-blind, on 21 nights. All active drugs were found effective in the mentally normal elderly, but in the psychogeriatric group of 20 patients, only propiomazine very significantly reduced the number of nocturnal awakenings and only diazepam almost significantly shortened the initial sleep latency, although duration of sleep was prolonged in both groups. There was neither loss of efficacy of the trial drugs nor rebound on withdrawal. Psychomotor skills and serum prolactin levels remained unaffected.

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confidence: 99%

Diazepam, Promethazine and Propiomazine as Hypnotics in Elderly Inpatients

Viukari¹,

Miettinen²

1984

Neuropsychobiology

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References

Laakmann¹

1990

Psychopharmacoendocrinology and Depression Research

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Pharmacology of saccadic eye movements in man

Ball¹,

Glue²,

Wilson³

et al. 1991

Psychopharmacology

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A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent slowing of peak velocity, peak acceleration, peak deceleration, reduced saccade acceleration/deceleration ratio and saccade accuracy, and increased sedation self-ratings. Changes in saccade variables and sedation ratings were significantly correlated, and also correlated with plasma midazolam concentrations. No significant changes were seen in saccade latency or anxiety self-ratings. Pharmacological specificity of these changes was demonstrated by their reversal with the benzodiazepine antagonist flumazenil. This challenge paradigm appears to be a sensitive means of assessing benzodiazepine receptor function in man.

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Long-term Benzodiazepine Administration Blunts Growth Hormone Response to Diazepam

Cited by 13 publications

References 25 publications

Diazepam, Promethazine and Propiomazine as Hypnotics in Elderly Inpatients

Diazepam, Promethazine and Propiomazine as Hypnotics in Elderly Inpatients

References

Pharmacology of saccadic eye movements in man

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