Long‐Term Binge and Escalating Ethanol Exposure Causes Necroinflammation and Fibrosis in Rat Liver

Zhou, Jihua; Jiang, Zhi-an; Zhao, Caiyan; Zhen, Zhen; Wang, Wei; Nanji, Amin A.

doi:10.1111/j.1530-0277.2012.01936.x

Cited by 25 publications

(25 citation statements)

References 49 publications

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“…Previous work has shown that hepatic insulin resistance and lipid peroxidation are important in the development of ALD (de la Monte et al, 2008;Yao et al, 2006). We have recently used an animal model to help further explore the pathogenesis of alcoholic liver injury (Zhou et al, 2013). EtOH (5 to 9 g/kg/d IG) twice a day (9:00 and 16:00) for 16 weeks was used to mimic the effects of EtOH in the development of ALD.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Insulin Resistance in the Protective Effect of Metformin Against Alcoholic Liver Injury

Zhu

Jiang

Zhou

et al. 2014

Alcohol Clin Exp Res

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Section: Discussionmentioning

confidence: 99%

Involvement of Insulin Resistance in the Protective Effect of Metformin Against Alcoholic Liver Injury

Zhu

Jiang

Zhou

et al. 2014

Alcohol Clin Exp Res

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“…COX-1 is constitutively expressed in multiple tissues, while COX-2 is inducible by a variety of stimuli. Previous studies have reported the upregulation of COX-2 in cirrhotic livers, which indicates that COX-2 may be involved in the process of liver cirrhosis (6,7). However, the involvement of COX-2 in the progression of liver fibrosis is controversial.…”

Section: Introductionmentioning

confidence: 86%

Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride

Tang

Gao

Wen

et al. 2017

Molecular Medicine Reports

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Multiple long non-coding RNAs (lncRNAs) have been demonstrated to be involved in liver disease. Increased cyclooxygenase-2 (COX-2) levels have also been reported to be involved in the progression of liver cirrhosis. In the present study, the correlations between lncRNA-COX-2 RNA expression levels, COX-2 mRNA expression levels and liver fibrosis were examined. Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) in mice for 2 months (CCl4-2M) or 3 months (CCl4-3M). Liver histopathological evaluation was conducted using hematoxylin and eosin and Masson trichrome staining. Hepatic expression of COX-2 and lncRNA-COX-2 was evaluated by reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining. Compared with the control group, fibrotic areas were increased four and nine times in the CCl4-2M group and the CCl4-3M group, respectively. LncRNA-COX-2 and COX-2 upregulation were observed in the cirrhotic liver. COX-2 mRNA expression levels and lncRNA-COX-2 RNA expression levels were significantly positively correlated with the fibrotic area. In addition, COX-2 mRNA expression was significantly positively correlated with lncRNA-COX-2 expression. These results suggest that expression of COX-2 and lncRNA-COX-2 increased with the progression of liver fibrosis. LncRNA-COX-2 may potentially be considered as a novel therapeutic target for liver fibrosis.

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“…Although no direct correlations have been made between alcohol and tumor hypoxia, alcohol increases HIF-1alpha via oxidative stress in a rat model for alcoholic liver disease [49]. Alcohol is metabolized to acetaldehyde, a known carcinogen, by alcohol dehydrogenase (ADH) situated in the liver, gastric mucosa, oesophageal mucosa and oral mucosa [50].…”

Section: General Conditions Influencing Tumor Hypoxiamentioning

confidence: 99%

Current relevance of hypoxia in head and neck cancer

et al. 2016

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Head and Neck cancer (HNC) is a complex mix of cancers and one of the more common cancers with a relatively poor prognosis. One of the factors that may assist us in predicting survival and allow us to adjust our treatment strategies is the presence of tumor hypoxia. In this overview we aim to evaluate the current evidence and potential clinical relevance of tumor hypoxia in head and neck cancer according to an extensive search of current literature.An abundance of evidence and often contradictory evidence is found in the literature. Even the contradictory evidence and comparisons are difficult to judge as criteria and methodologies differ greatly, furthermore few prospective observational studies exist for verification of the pre-clinical studies. Despite these discrepancies there is clear evidence of associations between prognosis and poor tumor oxygenation biomarkers such as HIF-1α, GLUT-1 and lactate, though these associations are not exclusive. The use of genetic markers is expanding and will probably lead to significantly more and complex evidence. The lack of oxygenation in head and neck tumors is of paramount importance for the prediction of treatment outcomes and prognosis. Despite the wide array of conflicting evidence, the drive towards non-invasive prediction of tumor hypoxia should continue.

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Long‐Term Binge and Escalating Ethanol Exposure Causes Necroinflammation and Fibrosis in Rat Liver

Cited by 25 publications

References 49 publications

Involvement of Insulin Resistance in the Protective Effect of Metformin Against Alcoholic Liver Injury

Involvement of Insulin Resistance in the Protective Effect of Metformin Against Alcoholic Liver Injury

Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride

Current relevance of hypoxia in head and neck cancer

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